Recent updates on clinical developments of curcumin and its derivatives.
clinical trials
curcumin
molecular targets
preclinical studies
therapeutic potential
Journal
Phytotherapy research : PTR
ISSN: 1099-1573
Titre abrégé: Phytother Res
Pays: England
ID NLM: 8904486
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
revised:
19
06
2023
received:
24
12
2022
accepted:
15
07
2023
medline:
10
11
2023
pubmed:
4
8
2023
entrez:
3
8
2023
Statut:
ppublish
Résumé
Curcumin, a natural polyphenol, derived from Curcuma longa L. is extensively studied by various researchers across the globe and has established its immense potential in the management of several disorders at clinical level. The underlying mechanism of curcumin involves regulation of various molecular targets, namely, inflammatory cytokines, transcription factor, apoptotic genes, growth factors, oxidative stress biomarkers, and protein kinases. In clinical trials, curcumin as an adjuvant has significantly boost-up the efficacy of many proven drugs in the management of arthritis, neurodegenerative disorder, oral infection, and gastrointestinal disorders. Moreover, clinical studies have suggested curcumin as an appropriate candidate for the prevention and/or management of various cancers via regulation of signaling molecules including NF-kB, cytokines, C-reactive protein, prostaglandin E2, Nrf2, HO-1, ALT, AST, kinases, and blood profiles. This article highlights plethora of clinical trials that have been conducted on curcumin and its derivatives in the management of several ailments. Besides, it provides recent updates to the investigators for conducting future research to fulfill the current gaps to expedite the curcumin utility in clinical subjects bearing different pathological states.
Substances chimiques
Curcumin
IT942ZTH98
NF-kappa B
0
Cytokines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
5109-5158Informations de copyright
© 2023 John Wiley & Sons Ltd.
Références
Abdolahi, M., Jafarieh, A., Sarraf, P., Sedighiyan, M., Yousefi, A., Tafakhori, A., Abdollahi, H., Salehinia, F., & Djalali, M. (2019). The neuromodulatory effects of ω-3 fatty acids and nano-curcumin on the COX-2/iNOS network in migraines: A clinical trial study from gene expression to clinical symptoms. Endocrine, Metabolic & Immune Disorders-Drug Targets, 19(6), 874-884.
Abidi, A., Gupta, S., Agarwal, M., Bhalla, H. L., & Saluja, M. (2014). Evaluation of efficacy of curcumin as an add-on therapy in patients of bronchial asthma. Journal of Clinical and Diagnostic Research, 8(8), 19.
Adab, Z., Eghtesadi, S., Vafa, M. R., Heydari, I., Shojaii, A., Haqqani, H., Arablou, T., & Eghtesadi, M. (2019). Effect of turmeric on glycemic status, lipid profile, hs-CRP, and total antioxidant capacity in hyperlipidemic type 2 diabetes mellitus patients. Phytotherapy Research, 33(4), 1173-1181.
Adhvaryu, M. R., Reddy, N. M., & Vakharia, B. C. (2008). Prevention of hepatotoxicity due to anti-tuberculosis treatment: A novel integrative approach. World Journal of Gastroenterology, 14(30), 4753-4762.
Agarwal, K. A., Tripathi, C. D., Agarwal, B. B., & Saluja, S. (2011). Efficacy of turmeric (curcumin) in pain and postoperative fatigue after laparoscopic cholecystectomy: A double-blind, randomized placebo-controlled study. Surgical Endoscopy, 25, 3805-3810.
Agarwal, N., Singh, D., Sinha, A., Srivastava, S., Prasad, R. K., & Singh, G. (2014). Evaluation of efficacy of turmeric in management of oral submucous fibrosis. Journal of Indian Academy of Oral Medicine and Radiology, 26(3), 260-263.
Akazawa, N., Choi, Y., Miyaki, A., Tanabe, Y., Sugawara, J., Ajisaka, R., & Maeda, S. (2012). Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women. Nutrition Research, 32(10), 795-799.
Allegri, P., Mastromarino, A., & Neri, P. (2010). Management of chronic anterior uveitis relapses: Efficacy of oral phospholipidic curcumin treatment. Long-term follow-up. Clinical Ophthalmology, 21, 1201-1206.
Alwi, I., Santoso, T., Suyono, S., Sutrisna, B., Suyatna, F. D., Kresno, S. B., & Ernie, S. (2008). The effect of curcumin on lipid level in patients with acute coronary syndrome. Acta Medica Indonesiana, 40(4), 201-210.
Amalraj, A., Varma, K., Jacob, J., Divya, C., Kunnumakkara, A. B., Stohs, S. J., & Gopi, S. (2017). A novel highly bioavailable curcumin formulation improves symptoms and diagnostic indicators in rheumatoid arthritis patients: A randomized, double-blind, placebo-controlled, two-dose, three-arm, and parallel-group study. Journal of Medicinal Food, 20(10), 1022-1030.
Amin, F., Islam, N., Anila, N., & Gilani, A. H. (2015). Clinical efficacy of the co-administration of turmeric and black seeds (Kalongi) in metabolic syndrome-A double blind randomized controlled trial-TAK-MetS trial. Complementary Therapies in Medicine, 23(2), 165-174.
Amirchaghmaghi, M., Pakfetrat, A., Delavarian, Z., Ghalavani, H., & Ghazi, A. (2016). Evaluation of the efficacy of curcumin in the treatment of oral lichen planus: A randomized controlled trial. Journal of Clinical and Diagnostic Research, 10(5), ZC134-ZC137.
Anand, P., Kunnumakkara, A. B., Newman, R. A., & Aggarwal, B. B. (2007). Bioavailability of curcumin: Problems and promises. Molecular Pharmaceutics, 4(6), 807-818.
Anitha, V., Rajesh, P., Shanmugam, M., Priya, B. M., Prabhu, S., & Shivakumar, V. (2015). Comparative evaluation of natural curcumin and synthetic chlorhexidine in the management of chronic periodontitis as a local drug delivery: A clinical and microbiological study. Indian Journal of Dental Research, 26(1), 53-56.
Antiga, E., Bonciolini, V., Volpi, W., del Bianco, E., & Caproni, M. (2015). Oral curcumin (Meriva) is effective as an adjuvant treatment and is able to reduce IL-22 serum levels in patients with psoriasis vulgaris. BioMed Research International, 13, 283634.
Appelboom, T., Maes, N., & Albert, A. (2014). A new curcuma extract (Flexofytol®) in osteoarthritis: Results from a Belgian real-life experience. The Open Rheumatology Journal., 8, 77-81.
Appendino, G., Belcaro, G., Cornelli, U., Luzzi, R., Togni, S., Dugall, M., Cesarone, M. R., Feragalli, B., Ippolito, E., Errichi, B. M., & Pellegrini, L. (2011). Potential role of curcumin phytosome (Meriva) in controlling the evolution of diabetic microangiopathy. A pilot study. Panminerva Medica, 53(3 Suppl 1), 43-49.
Araujo, C. A., & Leon, L. L. (2001). Biological activities of Curcuma longa L. Memórias do Instituto Oswaldo Cruz, 96, 723-728.
Asadi, S., Gholami, M. S., Siassi, F., Qorbani, M., Khamoshian, K., & Sotoudeh, G. (2019). Nano curcumin supplementation reduced the severity of diabetic sensorimotor polyneuropathy in patients with type 2 diabetes mellitus: A randomized double-blind placebo-controlled clinical trial. Complementary Therapies in Medicine, 43, 253-260.
Asawanonda, P., & Klahan, S. O. (2010). Tetrahydrocurcuminoid cream plus targeted narrowband UVB phototherapy for vitiligo: A preliminary randomized controlled study. Photomedicine and Laser Surgery, 28(5), 679-684.
Aslanabadi, N., Entezari-Maleki, T., Rezaee, H., Jafarzadeh, H. R., & Vahedpour, R. (2019). Curcumin for the prevention of myocardial injury following elective percutaneous coronary intervention; a pilot randomized clinical trial. European Journal of Pharmacology, 858, 172471.
Bahraini, P., Rajabi, M., Mansouri, P., Sarafian, G., Chalangari, R., & Azizian, Z. (2018). Turmeric tonic as a treatment in scalp psoriasis: A randomized placebo-control clinical trial. Journal of Cosmetic Dermatology, 17(3), 461-466.
Basu, P., Dutta, S., Begum, R., Mittal, S., Dutta, P. D., Bharti, A. C., Panda, C. K., Biswas, J., Dey, B., Talwar, G. P., & Das, B. C. (2013). Clearance of cervical human papillomavirus infection by topical application of curcumin and curcumin containing polyherbal cream: A phase II randomized controlled study. Asian Pacific Journal of Cancer Prevention, 14(10), 5753-5759.
Baum, L., Cheung, S. K., Mok, V. C., Lam, L. C., Leung, V. P., Hui, E., Ng, C. C., Chow, M., Ho, P. C., Lam, S., & Woo, J. (2007). Curcumin effects on blood lipid profile in a 6-month human study. Pharmacological Research, 56(6), 509-514.
Baum, L., Lam, C. W., Cheung, S. K., Kwok, T., Lui, V., Tsoh, J., Lam, L., Leung, V., Hui, E., Ng, C., & Woo, J. (2008). Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease. Journal of Clinical Psychopharmacology, 28(1), 110-113.
Bayet-Robert, M., Kwiatowski, F., Leheurteur, M., Gachon, F., Planchat, E., Abrial, C., Mouret-Reynier, M. A., Durando, X., Barthomeuf, C., & Chollet, P. (2010). Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer. Cancer Biology & Therapy, 9(1), 8-14.
Behal, R., Mali, A. M., Gilda, S. S., & Paradkar, A. R. (2011). Evaluation of local drug-delivery system containing 2% whole turmeric gel used as an adjunct to scaling and root planing in chronic periodontitis: A clinical and microbiological study. Journal of Indian Society of Periodontology, 15(1), 35-38.
Belcaro, G., Cesarone, M. R., Dugall, M., Pellegrini, L., Ledda, A., Grossi, M. G., Togni, S., & Appendino, G. (2010a). Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Alternative Medicine Review, 15(4), 337-344.
Belcaro, G., Cesarone, M. R., Dugall, M., Pellegrini, L., Ledda, A., Grossi, M. G., Togni, S., & Appendino, G. (2010b). Product-evaluation registry of Meriva®, a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis. Panminerva Medica, 52, 55-62.
Bergman, J., Miodownik, C., Bersudsky, Y., Sokolik, S., Lerner, P. P., Kreinin, A., Polakiewicz, J., & Lerner, V. (2013). Curcumin as an add-on to antidepressive treatment: A randomized, double-blind, placebo-controlled, pilot clinical study. Clinical Neuropharmacology, 36(3), 73-77.
Bhatia, M., Urolagin, S. S., Pentyala, K. B., Urolagin, S. B., Menaka, K. B., & Bhoi, S. (2014). Novel therapeutic approach for the treatment of periodontitis by curcumin. Journal of Clinical and Diagnostic Research, 8(12), ZC65-ZC69.
Bilia, A. R., Bergonzi, M. C., Isacchi, B., Antiga, E., & Caproni, M. (2018). Curcumin nanoparticles potentiate therapeutic effectiveness of acitretin in moderate-to-severe psoriasis patients and control serum cholesterol levels. The Journal of Pharmacy and Pharmacology, 70(7), 919-928.
Biswas, J., Sinha, D., Mukherjee, S., Roy, S., Siddiqi, M., & Roy, M. (2010). Curcumin protects DNA damage in a chronically arsenic-exposed population of West Bengal. Human & Experimental Toxicology, 29(6), 513-524.
Biswas, N. R., Gupta, S. K., Das, G. K., Kumar, N., Mongre, P. K., Haldar, D., & Beri, S. (2001). Evaluation of Ophthacare® eye drops-A herbal formulation in the management of various ophthalmic disorders. Phytotherapy Research, 15(7), 618-620.
Bundy, R., Walker, A. F., Middleton, R. W., & Booth, J. (2004). Turmeric extract may improve irritable bowel syndrome symptomology in otherwise healthy adults: A pilot study. Journal of Alternative and Complementary Medicine, 10(6), 1015-1018.
Cai, T., Mazzoli, S., Bechi, A., Addonisio, P., Mondaini, N., Pagliai, R. C., & Bartoletti, R. (2009). Serenoa repens associated with Urtica dioica (ProstaMEV®) and curcumin and quercitin (FlogMEV®) extracts are able to improve the efficacy of prulifloxacin in bacterial prostatitis patients: Results from a prospective randomised study. International Journal of Antimicrobial Agents, 33(6), 549-553.
Carroll, R. E., Benya, R. V., Turgeon, D. K., Vareed, S., Neuman, M., Rodriguez, L., Kakarala, M., Carpenter, P. M., McLaren, C., Meyskens, F. L., Jr., & Brenner, D. E. (2011). Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia. Cancer Prevention Research, 4(3), 354-364.
Chainani-Wu, N., Collins, K., & Silverman, S., Jr. (2012). Use of curcuminoids in a cohort of patients with oral lichen planus, an autoimmune disease. Phytomedicine, 19(5), 418-423.
Chainani-Wu, N., Madden, E., Lozada-Nur, F., & Silverman, S., Jr. (2012). High-dose curcuminoids are efficacious in the reduction in symptoms and signs of oral lichen planus. Journal of the American Academy of Dermatology, 66(5), 752-760.
Chainani-Wu, N., Silverman, S., Jr., Reingold, A., Bostrom, A., Mc Culloch, C., Lozada-Nur, F., & Weintraub, J. (2007). A randomized, placebo-controlled, double-blind clinical trial of curcuminoids in oral lichen planus. Phytomedicine, 14(7-8), 437-446.
Chandran, B., & Goel, A. (2012). A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytotherapy Research, 26(11), 1719-1725.
Chuengsamarn, S., Rattanamongkolgul, S., Luechapudiporn, R., Phisalaphong, C., & Jirawatnotai, S. (2012). Curcumin extract for prevention of type 2 diabetes. Diabetes Care, 35(11), 2121-2127.
Cicero, A. F., Sahebkar, A., Fogacci, F., Bove, M., Giovannini, M., & Borghi, C. (2020). Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: A double-blind, placebo-controlled clinical trial. European Journal of Nutrition, 59, 477-483.
Conrozier, T., Mathieu, P., Bonjean, M., Marc, J. F., Renevier, J. L., & Balblanc, J. C. (2014). A complex of three natural anti-inflammatory agents provides relief of osteoarthritis pain. Alternative Therapies in Health and Medicine, Winter(20) Suppl 1, 32-37.
Cox, K. H., Pipingas, A., & Scholey, A. B. (2015). Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. Journal of Psychopharmacology, 29(5), 642-651.
Cruz-Correa, M., Hylind, L. M., Marrero, J. H., Zahurak, M. L., Murray-Stewart, T., Casero, R. A., Jr., Montgomery, E. A., Iacobuzio-Donahue, C., Brosens, L. A., Offerhaus, G. J., & Umar, A. (2018). Efficacy and safety of curcumin in treatment of intestinal adenomas in patients with familial adenomatous polyposis. Gastroenterology, 155(3), 668-673.
Cruz-Correa, M., Shoskes, D. A., Sanchez, P., Zhao, R., Hylind, L. M., Wexner, S. D., & Giardiello, F. M. (2006). Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis. Clinical Gastroenterology and Hepatology, 4(8), 1035-1038.
Cuomo, J., Appendino, G., Dern, A. S., Schneider, E., McKinnon, T. P., Brown, M. J., Togni, S., & Dixon, B. M. (2011). Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation. Journal of Natural Products, 74(4), 664-669.
Das, D. A., Balan, A., & Sreelatha, K. T. (2010). Comparative study of the efficacy of curcumin and turmeric oil as chemopreventive agents in oral submucous fibrosis: A clinical and histopathological evaluation. Journal of Indian Academy of Oral Medicine and Radiology, 22(2), 88.
Dcodhar, S. D., Sethi, R., & Srimal, R. C. (1980). Preliminary study on antirheumatic activity of curcumin (diferuloylmethane). The Indian Journal of Medical Research, 71(1), 632-634.
Dhillon, N., Aggarwal, B. B., Newman, R. A., Wolff, R. A., Kunnumakkara, A. B., Abbruzzese, J. L., Ng, C. S., Badmaev, V., & Kurzrock, R. (2008). Phase II trial of curcumin in patients with advanced pancreatic cancer. Clinical Cancer Research, 14(14), 4491-4499.
di Mario, F., Cavallaro, L. G., Nouvenne, A., Stefani, N., Cavestro, G. M., Iori, V., Maino, M., Comparato, G., Fanigliulo, L., Morana, E., & Pilotto, A. (2007). A curcumin-based 1-week triple therapy for eradication of helicobacter pylori infection: Something to learn from failure? Helicobacter, 12(3), 238-243.
Di Pierro, F., Bressan, A., Ranaldi, D., Rapacioli, G., Giacomelli, L., & Bertuccioli, A. (2015). Potential role of bioavailable curcumin in weight loss and omental adipose tissue decrease: Preliminary data of a randomized, controlled trial in overweight people with metabolic syndrome. Preliminary study. European Review for Medical and Pharmacological Sciences, 19(21), 4195-4202.
DiSilvestro, R. A., Joseph, E., Zhao, S., & Bomser, J. (2012). Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. Nutrition Journal, 11, 1-8.
dos Santos Filho, E. X., Arantes, D. A., Leite, A. F., Batista, A. C., de Mendonca, E. F., Marreto, R. N., Naves, L. N., Lima, E. M., & Valadares, M. C. (2018). Randomized clinical trial of a mucoadhesive formulation containing curcuminoids (Zingiberaceae) and Bidens pilosa Linn (Asteraceae) extract (FITOPROT) for prevention and treatment of oral mucositis-phase I study. Chemico-Biological Interactions, 291, 228-236.
Durgaprasad, S., Pai, C. G., & Alvres, J. F. (2005). A pilot study of the antioxidant effect of curcumin in tropical pancreatitis. The Indian Journal of Medical Research, 122(4), 315-318.
Dützmann, S., Schiborr, C., Kocher, A., Pilatus, U., Hattingen, E., Weissenberger, J., Geßler, F., Quick-Weller, J., Franz, K., Seifert, V., & Frank, J. (2016). Intratumoral concentrations and effects of orally administered micellar curcuminoids in glioblastoma patients. Nutrition and Cancer, 68(6), 943-948.
Epelbaum, R., Schaffer, M., Vizel, B., Badmaev, V., & Bar-Sela, G. (2010). Curcumin and gemcitabine in patients with advanced pancreatic cancer. Nutrition and Cancer, 62(8), 1137-1141.
Esmaily, H., Sahebkar, A., Iranshahi, M., Ganjali, S., Mohammadi, A., Ferns, G., & Ghayour-Mobarhan, M. (2015). An investigation of the effects of curcumin on anxiety and depression in obese individuals: A randomized controlled trial. Chinese Journal of Integrative Medicine, 21, 332-338.
Ferguson, J. J., Stojanovski, E., MacDonald-Wicks, L., & Garg, M. L. (2018). Curcumin potentiates cholesterol-lowering effects of phytosterols in hypercholesterolaemic individuals. A randomised controlled trial. Metabolism., 82, 22-35.
Forrester, S. J., Booz, G. W., Sigmund, C. D., Coffman, T. M., Kawai, T., Rizzo, V., Scalia, R., & Eguchi, S. (2018). Angiotensin II signal transduction: An update on mechanisms of physiology and pathophysiology. Physiological Reviews, 98(3), 1627-1738.
Ganjali, S., Sahebkar, A., Mahdipour, E., Jamialahmadi, K., Torabi, S., Akhlaghi, S., Ferns, G., Parizadeh, S. M., & Ghayour-Mobarhan, M. (2014). Investigation of the effects of curcumin on serum cytokines in obese individuals: A randomized controlled trial. The Scientific World Journal, 2014, 898361.
Garcea, G., Berry, D. P., Jones, D. J., Singh, R., Dennison, A. R., Farmer, P. B., Sharma, R. A., Steward, W. P., & Gescher, A. J. (2005). Consumption of the putative chemopreventive agent curcumin by cancer patients: Assessment of curcumin levels in the colorectum and their pharmacodynamic consequences. Cancer Epidemiology, Biomarkers & Prevention, 14(1), 120-125.
Ghalaut, V. S., Sangwan, L., Dahiya, K., Ghalaut, P. S., Dhankhar, R., & Saharan, R. (2012). Effect of imatinib therapy with and without turmeric powder on nitric oxide levels in chronic myeloid leukemia. Journal of Oncology Pharmacy Practice, 18(2), 186-190.
Golombick, T., Diamond, T. H., Badmaev, V., Manoharan, A., & Ramakrishna, R. (2009). The potential role of curcumin in patients with monoclonal Gammopathy of undefined significance-Its effect on Paraproteinemia and the urinary N-Telopeptide of type I collagen bone turnover MarkerThe role of curcumin in MGUS. Clinical Cancer Research, 15(18), 5917-5922.
Gota, V. S., Maru, G. B., Soni, T. G., Gandhi, T. R., Kochar, N., & Agarwal, M. G. (2010). Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers. Journal of Agricultural and Food Chemistry, 58(4), 2095-2099.
Gottumukkala, S. N., Koneru, S., Mannem, S., & Mandalapu, N. (2013). Effectiveness of sub-gingival irrigation of an indigenous 1% curcumin solution on clinical and microbiological parameters in chronic periodontitis patients: A pilot randomized clinical trial. Contemporary Clinical Dentistry., 4(2), 186-191.
Gottumukkala, S. N., Sudarshan, S., & Mantena, S. R. (2014). Comparative evaluation of the efficacy of two controlled release devices: Chlorhexidine chips and indigenous curcumin-based collagen as local drug delivery systems. Contemporary Clinical Dentistry., 5(2), 175-181.
Greil, R., Greil-Ressler, S., Weiss, L., Schönlieb, C., Magnes, T., Radl, B., Bolger, G. T., Vcelar, B., & Sordillo, P. P. (2018). A phase 1 dose-escalation study on the safety, tolerability and activity of liposomal curcumin (Lipocurc™) in patients with locally advanced or metastatic cancer. Cancer Chemotherapy and Pharmacology, 82, 695-706.
Gupte, P. A., Giramkar, S. A., Harke, S. M., Kulkarni, S. K., Deshmukh, A. P., Hingorani, L. L., Mahajan, M. P., & Bhalerao, S. S. (2019). Evaluation of the efficacy and safety of capsule Longvida® optimized curcumin (solid lipid curcumin particles) in knee osteoarthritis: A pilot clinical study. Journal of Inflammation Research, 12, 145-152.
Hanai, H., Iida, T., Takeuchi, K., Watanabe, F., Maruyama, Y., Andoh, A., Tsujikawa, T., Fujiyama, Y., Mitsuyama, K., Sata, M., & Yamada, M. (2006). Curcumin maintenance therapy for ulcerative colitis: Randomized, multicenter, double-blind, placebo-controlled trial. Clinical Gastroenterology and Hepatology, 4(12), 1502-1506.
Haroyan, A., Mukuchyan, V., Mkrtchyan, N., Minasyan, N., Gasparyan, S., Sargsyan, A., Narimanyan, M., & Hovhannisyan, A. (2018). Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: A comparative, randomized, double-blind, placebo-controlled study. BMC Complementary and Alternative Medicine, 18(1), 1-6.
Hastak, K., Lubri, N., Jakhi, S. D., More, C., John, A., Ghaisas, S. D., & Bhide, S. V. (1997). Effect of turmeric oil and turmeric oleoresin on cytogenetic damage in patients suffering from oral submucous fibrosis. Cancer Letters, 116(2), 265-269.
Hazarey, V. K., Sakrikar, A. R., & Ganvir, S. M. (2015). Efficacy of curcumin in the treatment for oral submucous fibrosis-a randomized clinical trial. Journal of Oral and Maxillofacial Pathology, 19(2), 145-152.
He, Z. Y., Shi, C. B., Wen, H., Li, F. L., Wang, B. L., & Wang, J. (2011). Upregulation of p53 expression in patients with colorectal cancer by administration of curcumin. Cancer Investigation, 29(3), 208-213.
Hejazi, J., Rastmanesh, R., Taleban, F. A., Molana, S. H., Hejazi, E., Ehtejab, G., & Hara, N. (2016). Effect of curcumin supplementation during radiotherapy on oxidative status of patients with prostate cancer: A double blinded, randomized, placebo-controlled study. Nutrition and Cancer, 68(1), 77-85.
Heng, M. C., Song, M. K., Harker, J., & Heng, M. K. (2000). Drug-induced suppression of phosphorylase kinase activity correlates with resolution of psoriasis as assessed by clinical, histological and immunohistochemical parameters. The British Journal of Dermatology, 143(5), 937-949.
Henrotin, Y., Gharbi, M., Dierckxsens, Y., Priem, F., Marty, M., Seidel, L., Albert, A., Heuse, E., Bonnet, V., & Castermans, C. (2014). Decrease of a specific biomarker of collagen degradation in osteoarthritis, Coll2-1, by treatment with highly bioavailable curcumin during an exploratory clinical trial. BMC Complementary and Alternative Medicine, 14(1), 1-7.
Heshmati, J., Golab, F., Morvaridzadeh, M., Potter, E., Akbari-Fakhrabadi, M., Farsi, F., Tanbakooei, S., & Shidfar, F. (2020). The effects of curcumin supplementation on oxidative stress, Sirtuin-1 and peroxisome proliferator activated receptor γ coactivator 1α gene expression in polycystic ovarian syndrome (PCOS) patients: A randomized placebo-controlled clinical trial. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 14(2), 77-82.
Hodaei, H., Adibian, M., Nikpayam, O., Hedayati, M., & Sohrab, G. (2019). The effect of curcumin supplementation on anthropometric indices, insulin resistance and oxidative stress in patients with type 2 diabetes: A randomized, double-blind clinical trial. Diabetology and Metabolic Syndrome, 11, 1-8.
Holt, P. R., Katz, S., & Kirshoff, R. (2005). Curcumin therapy in inflammatory bowel disease: A pilot study. Digestive Diseases and Sciences, 50, 2191-2193.
Howells, L. M., Iwuji, C. O., Irving, G. R., Barber, S., Walter, H., Sidat, Z., Griffin-Teall, N., Singh, R., Foreman, N., Patel, S. R., & Morgan, B. (2019). Curcumin combined with FOLFOX chemotherapy is safe and tolerable in patients with metastatic colorectal cancer in a randomized phase IIa trial. The Journal of Nutrition, 149(7), 1133-1139.
Hsieh, C. J. (2001). Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Research, 21(2895), e2900.
Irving, G. R., Howells, L. M., Sale, S., Kralj-Hans, I., Atkin, W. S., Clark, S. K., Britton, R. G., Jones, D. J., Scott, E. N., Berry, D. P., & Hemingway, D. (2013). Prolonged biologically active colonic tissue levels of curcumin achieved after oral administration-A clinical pilot study including assessment of patient acceptability colonic levels of curcumin after oral administration-Clinical study. Cancer Prevention Research, 6(2), 119-128.
Ivanaga, C. A., Miessi, D. M., Nuernberg, M. A., Claudio, M. M., Garcia, V. G., & Theodoro, L. H. (2019). Antimicrobial photodynamic therapy (aPDT) with curcumin and LED, as an enhancement to scaling and root planing in the treatment of residual pockets in diabetic patients: A randomized and controlled split-mouth clinical trial. Photodiagnosis and Photodynamic Therapy, 27, 388-395.
Jain, S., Bisht, A., Verma, K., Negi, S., Paliwal, S., & Sharma, S. (2022). The role of fatty acid amide hydrolase enzyme inhibitors in Alzheimer's disease. Cell Biochemistry and Function, 40(2), 106-117.
Jain, S., Chauhan, N., Sharma, S., Reddy, K. R., Sadhu, V., & Kulkarni, R. V. (2020). The link between anxiety and Alzheimer's disease: Critical facts. Nanomaterials in Diagnostic Tools and Devices, 331-349.
James, M. I., Iwuji, C., Irving, G., Karmokar, A., Higgins, J. A., Griffin-Teal, N., Thomas, A., Greaves, P., Cai, H., Patel, S. R., & Morgan, B. (2015). Curcumin inhibits cancer stem cell phenotypes in ex vivo models of colorectal liver metastases, and is clinically safe and tolerable in combination with FOLFOX chemotherapy. Cancer Letters, 364(2), 135-141.
Javadi, M., Khadem Haghighian, H., Goodarzy, S., Abbasi, M., & Nassiri-Asl, M. (2019). Effect of curcumin nanomicelle on the clinical symptoms of patients with rheumatoid arthritis: A randomized, double-blind, controlled trial. International Journal of Rheumatic Diseases, 22(10), 1857-1862.
Jazayeri-Tehrani, S. A., Rezayat, S. M., Mansouri, S., Qorbani, M., Alavian, S. M., Daneshi-Maskooni, M., & Hosseinzadeh-Attar, M. J. (2019). Nano-curcumin improves glucose indices, lipids, inflammation, and Nesfatin in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD): A double-blind randomized placebo-controlled clinical trial. Nutrition and Metabolism, 16(1), 1-3.
Jiménez-Osorio, A. S., García-Niño, W. R., González-Reyes, S., Álvarez-Mejía, A. E., Guerra-León, S., Salazar-Segovia, J., Falcón, I., de Oca-Solano, H. M., Madero, M., & Pedraza-Chaverri, J. (2016). The effect of dietary supplementation with curcumin on redox status and Nrf2 activation in patients with nondiabetic or diabetic proteinuric chronic kidney disease: A pilot study. Journal of Renal Nutrition, 26(4), 237-244.
Joshi, P., Bisht, A., Joshi, S., Semwal, D., Nema, N. K., Dwivedi, J., & Sharma, S. (2022). Ameliorating potential of curcumin and its analogue in central nervous system disorders and related conditions: A review of molecular pathways. Phytotherapy Research, 36(8), 3143-3180.
Joshi, P., Joshi, S., Semwal, D., Bisht, A., Paliwal, S., Dwivedi, J., & Sharma, S. (2021). Curcumin: An insight into molecular pathways involved in anticancer activity. Mini Reviews in Medicinal Chemistry, 21(17), 2420-2457.
Joshi, P., Joshi, S., Semwal, D. K., Bisht, A., Sharma, S., & Dwivedi, J. (2021). Chemical composition, antioxidative and antimicrobial activities of turmeric spent oleoresin. Industrial Crops and Products, 162, 113278.
Joshi, P., Joshi, S., Semwal, D. K., Verma, K., Dwivedi, J., & Sharma, S. (2022). Role of curcumin in ameliorating hypertension and associated conditions: A mechanistic insight. Molecular and Cellular Biochemistry, 477(10), 2359-2385.
Judaki, A., Rahmani, A., Feizi, J., Asadollahi, K., & Hafezi Ahmadi, M. R. (2017). Turmeric in combination with triple therapy regimens improves oxidative stress and histopathologic changes in chronic gastritis associated with Helicobacter pylori infection. Gastroenterology Archives, 54(3), 177-182.
Kalpravidh, R. W., Siritanaratkul, N., Insain, P., Charoensakdi, R., Panichkul, N., Hatairaktham, S., Srichairatanakool, S., Phisalaphong, C., Rachmilewitz, E., & Fucharoen, S. (2010). Improvement in oxidative stress and antioxidant parameters in β-thalassemia/Hb E patients treated with curcuminoids. Clinical Biochemistry, 43(4-5), 424-429.
Kanai, M., Otsuka, Y., Otsuka, K., Sato, M., Nishimura, T., Mori, Y., Kawaguchi, M., Hatano, E., Kodama, Y., Matsumoto, S., & Murakami, Y. (2013). A phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin®) in cancer patients. Cancer Chemotherapy and Pharmacology, 71, 1521-1530.
Kanai, M., Yoshimura, K., Asada, M., Imaizumi, A., Suzuki, C., Matsumoto, S., Nishimura, T., Mori, Y., Masui, T., Kawaguchi, Y., & Yanagihara, K. (2011). A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer. Cancer Chemotherapy and Pharmacology, 68, 157-164.
Kertia, N., Asdie, A. H., & Rochmah, W. (2012). Ability of curcuminoid compared to diclofenac sodium in reducing the secretion of cycloxygenase-2 enzyme by synovial fluid's monocytes of patients with osteoarthritis. Acta Medica Indonesiana, 44(2), 105-113.
Khajehdehi, P., Pakfetrat, M., Javidnia, K., Azad, F., Malekmakan, L., Nasab, M. H., & Dehghanzadeh, G. (2011). Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-β and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: A randomized, double-blind and placebo-controlled study. Scandinavian Journal of Urology and Nephrology, 45(5), 365-370.
Khajehdehi, P., Zanjaninejad, B., Aflaki, E., Nazarinia, M., Azad, F., Malekmakan, L., & Dehghanzadeh, G. R. (2012). Oral supplementation of turmeric decreases proteinuria, hematuria, and systolic blood pressure in patients suffering from relapsing or refractory lupus nephritis: A randomized and placebo-controlled study. Journal of Renal Nutrition, 22(1), 50-57.
Khayat, S., Fanaei, H., Kheirkhah, M., Moghadam, Z. B., Kasaeian, A., & Javadimehr, M. (2015). Curcumin attenuates severity of premenstrual syndrome symptoms: A randomized, double-blind, placebo-controlled trial. Complementary Therapies in Medicine, 23(3), 318-324.
Kia, S. J., Basirat, M., & Estakhr, L. (2017). The effect of oral curcumin on pain and clinical appearance of oral lichen planus. Journal of Dentomaxillofacial., 6(1), 1-7.
Kia, S. J., Mansourian, A., Basirat, M., Akhavan, M., Mohtasham-Amiri, Z., & Moosavi, M. S. (2020). New concentration of curcumin orabase in recurrent aphthous stomatitis: A randomized, controlled clinical trial. Journal of Herbal Medicine, 22, 100336.
Kia, S. J., Shirazian, S., Mansourian, A., Fard, L. K., & Ashnagar, S. (2015). Comparative efficacy of topical curcumin and triamcinolone for oral lichen planus: A randomized, controlled clinical trial. Journal of Dentistry, 12(11), 789-796.
Kim, S. G., Veena, M. S., Basak, S. K., Han, E., Tajima, T., Gjertson, D. W., Starr, J., Eidelman, O., Pollard, H. B., Srivastava, M., & Srivatsan, E. S. (2011). Curcumin treatment suppresses IKKβ kinase activity of salivary cells of patients with head and neck cancer: A pilot StudyCurcumin suppresses salivary IKKβ kinase in HNSCC. Clinical Cancer Research, 17(18), 5953-5961.
Kim, S. W., Ha, K. C., Choi, E. K., Jung, S. Y., Kim, M. G., Kwon, D. Y., Yang, H. J., Kim, M. J., Kang, H. J., Back, H. I., & Kim, S. Y. (2013). The effectiveness of fermented turmeric powder in subjects with elevated alanine transaminase levels: A randomized controlled study. BMC Complementary and Alternative Medicine, 13, 1-8.
Kizhakkedath, R. (2013). Clinical evaluation of a formulation containing Curcuma longa and Boswellia serrata extracts in the management of knee osteoarthritis. Molecular Medicine Reports, 8(5), 1542-1548.
Koosirirat, C., Linpisarn, S., Changsom, D., Chawansuntati, K., & Wipasa, J. (2010). Investigation of the anti-inflammatory effect of Curcuma longa in Helicobacter pylori-infected patients. International Immunopharmacology, 10(7), 815-818.
Kopuri, R. K., Chakravarthy, C., Sunder, S., Patil, R. S., Shivaraj, W., & Arakeri, G. (2016). A comparative study of the clinical efficacy of lycopene and curcumin in the treatment of oral submucous fibrosis using ultrasonography. Journal of International Oral Health., 8(6), 687.
Kositchaiwat, C., Kositchaiwat, S., & Havanondha, J. (1993). Curcuma longa Linn. in the treatment of gastric ulcer comparison to liquid antacid: A controlled clinical trial. Chotmaihet Thangphaet [Journal of the Medical Association of Thailand], 76(11), 601-605.
Krishnareddy, N. T., Thomas, J. V., Nair, S. S., Mulakal, J. N., Maliakel, B. P., & Krishnakumar, I. M. (2018). A novel curcumin-Galactomannoside complex delivery system improves hepatic function markers in chronic alcoholics: A double-blinded, randomized, placebo-controlled study. BioMed Research International, 23, 2018-2010.
Kulkarni, R. R., Patki, P. S., Jog, V. P., Gandage, S. G., & Patwardhan, B. (1991). Treatment of osteoarthritis with a herbomineral formulation: A double-blind, placebo-controlled, cross-over study. Journal of Ethnopharmacology, 33(1-2), 91-95.
Kumar, A., Harsha, C., Parama, D., Girisa, S., Daimary, U. D., Mao, X., & Kunnumakkara, A. B. (2021). Current clinical developments in curcumin-based therapeutics for cancer and chronic diseases. Phytotherapy Research, 35(12), 6768-6801.
Kuptniratsaikul, V., Dajpratham, P., Taechaarpornkul, W., Buntragulpoontawee, M., Lukkanapichonchut, P., Chootip, C., Saengsuwan, J., Tantayakom, K., & Laongpech, S. (2014). Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: A multicenter study. Clinical Interventions in Aging, 20, 451-458.
Kuptniratsaikul, V., Thanakhumtorn, S., Chinswangwatanakul, P., Wattanamongkonsil, L., & Thamlikitkul, V. (2009). Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis. The Journal of Alternative and Complementary Medicine, 15(8), 891-897.
Kurd, S. K., Smith, N., VanVoorhees, A., Troxel, A. B., Badmaev, V., Seykora, J. T., & Gelfand, J. M. (2008). Oral curcumin in the treatment of moderate to severe psoriasis vulgaris: A prospective clinical trial. Journal of the American Academy of Dermatology, 58(4), 625-631.
Kuriakose, M. A., Ramdas, K., Dey, B., Iyer, S., Rajan, G., Elango, K. K., Suresh, A., Ravindran, D., Kumar, R. R., Ramachandran, S., & Kumar, N. A. (2016). A randomized double-blind placebo-controlled phase II B trial of curcumin in oral leukoplakia curcumin chemoprevention trial. Cancer Prevention Research, 9(8), 683-691.
Kuttan, R., Sudheeran, P. C., & Josph, C. D. (1987). Turmeric and curcumin as topical agents in cancer therapy. Tumori Journal., 73(1), 29-31.
Lal, B., Kapoor, A. K., Agrawal, P. K., Asthana, O. P., & Srimal, R. C. (2000). Role of curcumin in idiopathic inflammatory orbital pseudotumours. Phytotherapy Research, 14(6), 443-447.
Lal, B., Kapoor, A. K., Asthana, O. P., Agrawal, P. K., Prasad, R., Kumar, P., & Srimal, R. C. (1999). Efficacy of curcumin in the management of chronic anterior uveitis. Phytotherapy Research, 13(4), 318-322.
Lang, A., Salomon, N., Wu, J. C., Kopylov, U., Lahat, A., Har-Noy, O., Ching, J. Y., Cheong, P. K., Avidan, B., Gamus, D., & Kaimakliotis, I. (2015). Curcumin in combination with mesalamine induces remission in patients with mild-to-moderate ulcerative colitis in a randomized controlled trial. Clinical Gastroenterology and Hepatology, 13(8), 1444-1449.
Ledda, A., Belcaro, G., Dugall, M., Luzzi, R., Scoccianti, M., Togni, S., Appendino, G., & Ciammaichella, G. (2012). Meriva®, a lecithinized curcumin delivery system, in the control of benign prostatic hyperplasia: A pilot, product evaluation registry study. Panminerva Medica, 54(4), 17.
Leite, D. P., Paolillo, F. R., Parmesano, T. N., Fontana, C. R., & Bagnato, V. S. (2014). Effects of photodynamic therapy with blue light and curcumin as mouth rinse for oral disinfection: A randomized controlled trial. Photomedicine and Laser Surgery, 32(11), 627-632.
Lopresti, A. L., & Drummond, P. D. (2017). Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo-controlled study. Journal of Affective Disorders, 207, 188-196.
Lopresti, A. L., Maes, M., Maker, G. L., Hood, S. D., & Drummond, P. D. (2014). Curcumin for the treatment of major depression: A randomised, double-blind, placebo controlled study. Journal of Affective Disorders, 167, 368-375.
Lopresti, A. L., Maes, M., Meddens, M. J., Maker, G. L., Arnoldussen, E., & Drummond, P. D. (2015). Curcumin and major depression: A randomised, double-blind, placebo-controlled trial investigating the potential of peripheral biomarkers to predict treatment response and antidepressant mechanisms of change. European Neuropsychopharmacology, 25(1), 38-50.
Madhu, K., Chanda, K., & Saji, M. J. (2013). Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: A randomized placebo-controlled trial. Inflammopharmacology, 21, 129-136.
Maithili Karpaga Selvi, N., Sridhar, M. G., Swaminathan, R. P., & Sripradha, R. (2015). Efficacy of turmeric as adjuvant therapy in type 2 diabetic patients. Indian Journal of Clinical Biochemistry, 30, 180-186.
Mazzolani, F., & Togni, S. (2013). Oral administration of a curcumin-phospholipid delivery system for the treatment of central serous chorioretinopathy: A 12-month follow-up study. Clinical Ophthalmology (Auckland, NZ), 7, 939.
Mirzabeigi, P., Mohammadpour, A. H., Salarifar, M., Gholami, K., Mojtahedzadeh, M., & Javadi, M. R. (2015). The effect of curcumin on some of traditional and non-traditional cardiovascular risk factors: A pilot randomized, double-blind, placebo-controlled trial. Iranian Journal of Pharmaceutical Research, 14(2), 479-486.
Mohajer, A., Ghayour-Mobarhan, M., Parizadeh, S. M., Tavallaie, S., Rajabian, M., & Sahebkar, A. (2014). Effects of supplementation with curcuminoids on serum copper and zinc concentrations and superoxide dismutase enzyme activity in obese subjects. Trace Elements and Electrolytes, 32, 16-21.
Mohammadi, E., Tamaddoni, A., Qujeq, D., Nasseri, E., Zayeri, F., Zand, H., Gholami, M., & Mir, S. M. (2018). An investigation of the effects of curcumin on iron overload, hepcidin level, and liver function in β-thalassemia major patients: A double-blind randomized controlled clinical trial. Phytotherapy Research, 32(9), 1828-1835.
Moreillon, J. J., Bowden, R. G., Deike, E., Griggs, J., Wilson, R., Shelmadine, B., Cooke, M., & Beaujean, A. (2013). The use of an anti-inflammatory supplement in patients with chronic kidney disease. Journal of Complementary and Integrative Medicine., 10(1), 143-152.
Morgia, G., Russo, G. I., Urzì, D., Privitera, S., Castelli, T., Favilla, V., & Cimino, S. (2017). A phase II, randomized, single-blinded, placebo-controlled clinical trial on the efficacy of Curcumina and calendula suppositories for the treatment of patients with chronic prostatitis/chronic pelvic pain syndrome type III. Archivio Italiano di Urologia, Andrologia, 89(2), 110-113.
Muglikar, S., Patil, K. C., Shivswami, S., & Hegde, R. (2013). Efficacy of curcumin in the treatment of chronic gingivitis: A pilot study. Oral Health & Preventive Dentistry, 11(1), 81-86.
Na, L. X., Li, Y., Pan, H. Z., Zhou, X. L., Sun, D. J., Meng, M., Li, X. X., & Sun, C. H. (2013). Curcuminoids exert glucose-lowering effect in type 2 diabetes by decreasing serum free fatty acids: A double-blind, placebo-controlled trial. Molecular Nutrition & Food Research, 57(9), 1569-1577.
Na, L. X., Yan, B. L., Jiang, S., Cui, H. L., Li, Y., & Sun, C. H. (2014). Curcuminoids target decreasing serum adipocyte-fatty acid binding protein levels in their glucose-lowering effect in patients with type 2 diabetes. Biomedical and Environmental Sciences, 27(11), 902-906.
Nakagawa, Y., Mukai, S., Yamada, S., Matsuoka, M., Tarumi, E., Hashimoto, T., Tamura, C., Imaizumi, A., Nishihira, J., & Nakamura, T. (2014). Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: A randomized, double-blind, placebo-controlled prospective study. Journal of Orthopaedic Science, 19(6), 933-939.
Nakayama, H., Tsuge, N., Sawada, H., Masamura, N., Yamada, S., Satomi, S., & Higashi, Y. (2014). A single consumption of curry improved postprandial endothelial function in healthy male subjects: A randomized, controlled crossover trial. Nutrition Journal, 13(1), 1-7.
Nasseri, E., Mohammadi, E., Tamaddoni, A., Qujeq, D., Zayeri, F., & Zand, H. (2018). Benefits of curcumin supplementation on antioxidant status in β-thalassemia major patients: A double-blind randomized controlled clinical trial. Annals of Nutrition & Metabolism, 71(3-4), 136-144.
Navekar, R., Rafraf, M., Ghaffari, A., Asghari-Jafarabadi, M., & Khoshbaten, M. (2017). Turmeric supplementation improves serum glucose indices and leptin levels in patients with nonalcoholic fatty liver diseases. Journal of the American College of Nutrition, 36(4), 261-267.
Neerati, P., Devde, R., & Gangi, A. K. (2014). Evaluation of the effect of curcumin capsules on glyburide therapy in patients with type-2 diabetes mellitus. Phytotherapy Research, 28(12), 1796-1800.
Niederau, C., & Göpfert, E. (1999). The effect of chelidonium- and turmeric root extract on upper abdominal pain due to functional disorders of the biliary system. Results from a placebo-controlled double-blind study. Medizinische Klinik, 94(8), 425-430.
Nieman, D. C., Cialdella-Kam, L., Knab, A. M., & Shanely, R. A. (2012). Influence of red pepper spice and turmeric on inflammation and oxidative stress biomarkers in overweight females: A metabolomics approach. Plant Foods for Human Nutrition, 67(4), 415-421.
Nikpour, M., Delavar, M. A., Khafri, S., Ghanbarpour, A., Moghadamnia, A. A., Esmaeilzadeh, S., & Behmanesh, F. (2019). The use of honey and curcumin for episiotomy pain relief and wound healing: A three-group double-blind randomized clinical trial. Nursing and Midwifery Studies, 8(2), 64.
Nosratzehi, T., Arbabi-Kalati, F., Hamishehkar, H., & Bagheri, S. (2018). Comparison of the effects of curcumin mucoadhesive paste and local corticosteroid on the treatment of erosive oral lichen planus lesions. Journal of the National Medical Association, 110(1), 92-97.
Pakfetrat, M., Akmali, M., Malekmakan, L., Dabaghimanesh, M., & Khorsand, M. (2015). Role of turmeric in oxidative modulation in end-stage renal disease patients. Hemodialysis International, 1, 124-131.
Pakfetrat, M., Basiri, F., Malekmakan, L., & Roozbeh, J. (2014). Effects of turmeric on uremic pruritus in end stage renal disease patients: A double-blind randomized clinical trial. Journal of Nephrology, 27, 203-207.
Panahi, Y., Alishiri, G. H., Parvin, S., & Sahebkar, A. (2016). Mitigation of systemic oxidative stress by curcuminoids in osteoarthritis: Results of a randomized controlled trial. Journal of Dietary Supplements, 13(2), 209-220.
Panahi, Y., Ghanei, M., Bashiri, S., Hajihashemi, A., & Sahebkar, A. (2014). Short-term curcuminoid supplementation for chronic pulmonary complications due to sulfur mustard intoxication: Positive results of a randomized double-blind placebo-controlled trial. Drug Research, 30, 567-573.
Panahi, Y., Ghanei, M., Hajhashemi, A., & Sahebkar, A. (2016). Effects of curcuminoids-piperine combination on systemic oxidative stress, clinical symptoms and quality of life in subjects with chronic pulmonary complications due to sulfur mustard: A randomized controlled trial. Journal of Dietary Supplements, 13(1), 93-105.
Panahi, Y., Khalili, N., Hosseini, M. S., Abbasinazari, M., & Sahebkar, A. (2014). Lipid-modifying effects of adjunctive therapy with curcuminoids-piperine combination in patients with metabolic syndrome: Results of a randomized controlled trial. Complementary Therapies in Medicine, 22(5), 851-857.
Panahi, Y., Kianpour, P., Mohtashami, R., Jafari, R., Simental-Mendía, L. E., & Sahebkar, A. (2016). Curcumin lowers serum lipids and uric acid in subjects with nonalcoholic fatty liver disease: A randomized controlled trial. Journal of Cardiovascular Pharmacology, 68(3), 223-229.
Panahi, Y., Kianpour, P., Mohtashami, R., Jafari, R., Simental-Mendía, L. E., & Sahebkar, A. (2017). Efficacy and safety of phytosomal curcumin in non-alcoholic fatty liver disease: A randomized controlled trial. Drug Research, 67(4), 244-251.
Panahi, Y., Kianpour, P., Mohtashami, R., Soflaei, S. S., & Sahebkar, A. (2019). Efficacy of phospholipidated curcumin in nonalcoholic fatty liver disease: A clinical study. Journal of Asian Natural Products Research, 21(8), 798-805.
Panahi, Y., Rahimnia, A. R., Sharafi, M., Alishiri, G., Saburi, A., & Sahebkar, A. (2014). Curcuminoid treatment for knee osteoarthritis: A randomized double-blind placebo-controlled trial. Phytotherapy Research, 28(11), 1625-1631.
Panahi, Y., Sahebkar, A., Amiri, M., Davoudi, S. M., Beiraghdar, F., Hoseininejad, S. L., & Kolivand, M. (2012). Improvement of Sulphur mustard-induced chronic pruritus, quality of life and antioxidant status by curcumin: Results of a randomised, double-blind, placebo-controlled trial. The British Journal of Nutrition, 108(7), 1272-1279.
Panahi, Y., Sahebkar, A., Parvin, S., & Saadat, A. (2012). A randomized controlled trial on the anti-inflammatory effects of curcumin in patients with chronic Sulphur mustard-induced cutaneous complications. Annals of Clinical Biochemistry, 49(6), 580-588.
Pastorelli, D., Fabricio, A. S., Giovanis, P., D'Ippolito, S., Fiduccia, P., Soldà, C., Buda, A., Sperti, C., Bardini, R., Da Dalt, G., & Rainato, G. (2018). Phytosome complex of curcumin as complementary therapy of advanced pancreatic cancer improves safety and efficacy of gemcitabine: Results of a prospective phase II trial. Pharmacological Research, 132, 72-79.
Pinsornsak, P., & Niempoog, S. (2012). The efficacy of Curcuma longa L. extract as an adjuvant therapy in primary knee osteoarthritis: A randomized control trial. Journal of the Medical Association of Thailand, 95, 51-58.
Pipalia, P. R., Annigeri, R. G., & Mehta, R. (2016). Clinicobiochemical evaluation of turmeric with black pepper and Nigella sativa in management of oral submucous fibrosis-A double-blind, randomized preliminary study. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, 122(6), 705-712.
Polasa, K., Raghuram, T. C., Krishna, T. P., & Krishnaswamy, K. (1992). Effect of turmeric on urinary mutagens in smokers. Mutagenesis, 7(2), 107-109.
Portincasa, P., Bonfrate, L., Scribano, M. L., Kohn, A., Caporaso, N., Festi, D., Campanale, M. C., Di Rienzo, T., Guarino, M., Taddia, M., & Fogli, M. V. (2016). Curcumin and fennel essential oil improve symptoms and quality of life in patients with irritable bowel syndrome. Journal of Gastrointestinal and Liver Diseases, 25(2), 151-157.
Prucksunand, C., Indrasukhsri, B., Leethochawalit, M., & Hungspreugs, K. (2001). Phase II clinical trial on effect of the long turmeric (Curcuma longa Linn.) on healing of peptic ulcer. The Southeast Asian Journal of Tropical Medicine and Public Health, 32(1), 208-215.
Pulikkotil, S. J., & Nath, S. (2015). Effects of curcumin on crevicular levels of IL-1β and CCL 28 in experimental gingivitis. Australian Dental Journal, 60(3), 317-327.
Pungcharoenkul, K., & Thongnopnua, P. (2011). Effect of different curcuminoid supplement dosages on total in vivo antioxidant capacity and cholesterol levels of healthy human subjects. Phytotherapy Research, 25(11), 1721-1726.
Raghava, K. V., Sistla, K. P., Narayan, S. J., Yadalam, U., Bose, A., & Mitra, K. (2019). Efficacy of curcumin as an adjunct to scaling and root planing in chronic periodontitis patients: A randomized controlled clinical trial. The Journal of Contemporary Dental Practice., 20(7), 842-846.
Rahimi, H. R., Mohammadpour, A. H., Dastani, M., Jaafari, M. R., Abnous, K., Mobarhan, M. G., & Oskuee, R. K. (2016). The effect of nano-curcumin on HbA1c, fasting blood glucose, and lipid profile in diabetic subjects: A randomized clinical trial. Avicenna Journal of Phytomedicine, 6(5), 567-577.
Rahmani, S., Asgary, S., Askari, G., Keshvari, M., Hatamipour, M., Feizi, A., & Sahebkar, A. (2016). Treatment of non-alcoholic fatty liver disease with curcumin: A randomized placebo-controlled trial. Phytotherapy Research, 30(9), 1540-1548.
Rai, B., Kaur, J., Jacobs, R., & Singh, J. (2010). Possible action mechanism for curcumin in pre-cancerous lesions based on serum and salivary markers of oxidative stress. Journal of Oral Science, 52(2), 251-256.
Rainey-Smith, S. R., Brown, B. M., Sohrabi, H. R., Shah, T., Goozee, K. G., Gupta, V. B., & Martins, R. N. (2016). Curcumin and cognition: A randomised, placebo-controlled, double-blind study of community-dwelling older adults. The British Journal of Nutrition, 115(12), 2106-2113.
Rajuddin, R. A., Wiweko, B., & Nugroho, L. U. (2019). The effects of curcumin administration on expression patterns of VEGF and COX-2 in fertile endometrium: A randomized clinical trial. International Journal of Applied Pharmaceutics, 11, 149-152.
Ramırez-Boscá, A., Soler, A., Carrion, M. A., Dıaz-Alperi, J., Bernd, A., Quintanilla, C., Almagro, E. Q., & Miquel, J. (2000). An hydroalcoholic extract of Curcuma longa lowers the apo B/apo a ratio: Implications for atherogenesis prevention. Mechanisms of Ageing and Development, 119(1-2), 41-47.
Rao, S., Dinkar, C., Vaishnav, L. K., Rao, P., Rai, M. P., Fayad, R., & Baliga, M. S. (2014). The Indian spice turmeric delays and mitigates radiation-induced oral mucositis in patients undergoing treatment for head and neck cancer: An investigational study. Integrative Cancer Therapies, 13(3), 201-210.
Rasyid, A., & Lelo, A. (1999). The effect of curcumin and placebo on human gall-bladder function: An ultrasound study. Alimentary Pharmacology & Therapeutics, 13(2), 245-250.
Rasyid, A., Rahman, A. R., Jaalam, K., & Lelo, A. (2002). Effect of different curcumin dosages on human gall bladder. Asia Pacific Journal of Clinical Nutrition, 11(4), 314-318.
Ringman, J. M., Frautschy, S. A., Teng, E., Begum, A. N., Bardens, J., Beigi, M., Gylys, K. H., Badmaev, V., Heath, D. D., Apostolova, L. G., & Porter, V. (2012). Oral curcumin for Alzheimer's disease: Tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study. Alzheimer's Research & Therapy, 4, 1-8.
Ryan, J. L., Heckler, C. E., Ling, M., Katz, A., Williams, J. P., Pentland, A. P., & Morrow, G. R. (2013). Curcumin for radiation dermatitis: A randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients. Radiation Research, 180(1), 34-43.
Saadati, S., Sadeghi, A., Mansour, A., Yari, Z., Poustchi, H., Hedayati, M., Hatami, B., & Hekmatdoost, A. (2019). Curcumin and inflammation in non-alcoholic fatty liver disease: A randomized, placebo controlled clinical trial. BMC Gastroenterology, 19(1), 1-6.
Sadeghi, N., Mansoori, A., Shayesteh, A., & Hashemi, S. J. (2020). The effect of curcumin supplementation on clinical outcomes and inflammatory markers in patients with ulcerative colitis. Phytotherapy Research, 34(5), 1123-1133.
Saghatelyan, T., Tananyan, A., Janoyan, N., Tadevosyan, A., Petrosyan, H., Hovhannisyan, A., Hayrapetyan, L., Arustamyan, M., Arnhold, J., Rotmann, A. R., & Hovhannisyan, A. (2020). Efficacy and safety of curcumin in combination with paclitaxel in patients with advanced, metastatic breast cancer: A comparative, randomized, double-blind, placebo-controlled clinical trial. Phytomedicine, 70, 153218.
Sahebkar, A., Mohammadi, A., Atabati, A., Rahiman, S., Tavallaie, S., Iranshahi, M., Akhlaghi, S., Ferns, G. A., & Ghayour-Mobarhan, M. (2013). Curcuminoids modulate pro-oxidant-antioxidant balance but not the immune response to heat shock protein 27 and oxidized LDL in obese individuals. Phytotherapy Research, 27(12), 1883-1888.
Sanmukhani, J., Satodia, V., Trivedi, J., Patel, T., Tiwari, D., Panchal, B., Goel, A., & Tripathi, C. B. (2014). Efficacy and safety of curcumin in major depressive disorder: A randomized controlled trial. Phytotherapy Research, 28(4), 579-585.
Santos-Parker, J. R., Strahler, T. R., Bassett, C. J., Bispham, N. Z., Chonchol, M. B., & Seals, D. R. (2017). Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress. Aging (Albany NY), 9(1), 187-208.
Saraf-Bank, S., Ahmadi, A., Paknahad, Z., Maracy, M., & Nourian, M. (2019a). Effects of curcumin on cardiovascular risk factors in obese and overweight adolescent girls: A randomized clinical trial. São Paulo Medical Journal, 137, 414-422.
Saraf-Bank, S., Ahmadi, A., Paknahad, Z., Maracy, M., & Nourian, M. (2019b). Effects of curcumin supplementation on markers of inflammation and oxidative stress among healthy overweight and obese girl adolescents: A randomized placebo-controlled clinical trial. Phytotherapy Research, 33(8), 2015-2022.
Satoskar, R. R., Shah, S. J., & Shenoy, S. G. (1986). Evaluation of anti-inflammatory property of curcumin (diferuloylmethane) in patients with postoperative inflammation. International Journal of Clinical Pharmacology, Therapy, and Toxicology, 24(12), 651-654.
Sharma, R. A., McLelland, H. R., Hill, K. A., Ireson, C. R., Euden, S. A., Manson, M. M., Pirmohamed, M., Marnett, L. J., Gescher, A. J., & Steward, W. P. (2001). Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer. Clinical Cancer Research, 7(7), 1894-1900.
Shelmadine, B. D., Bowden, R. G., Moreillon, J. J., Cooke, M. B., Yang, P., Deike, E., Griggs, J. O., & Wilson, R. L. (2017). A pilot study to examine the effects of an anti-inflammatory supplement on eicosanoid derivatives in patients with chronic kidney disease. The Journal of Alternative and Complementary Medicine, 23(8), 632-638.
Shimouchi, A., Nose, K., Takaoka, M., Hayashi, H., & Kondo, T. (2009). Effect of dietary turmeric on breath hydrogen. Digestive Diseases and Sciences, 54, 1725-1729.
Shoba, G., Joy, D., Joseph, T., Majeed, M., Rajendran, R., & Srinivas, P. S. (1998). Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica, 64(4), 353-356.
Shoskes, D., Lapierre, C., Cruz-Corerra, M., Muruve, N., Rosario, R., Fromkin, B., Braun, M., & Copley, J. (2005). Beneficial effects of the bioflavonoids curcumin and quercetin on early function in cadaveric renal transplantation: A randomized placebo controlled trial. Transplantation, 80(11), 1556-1559.
Singh, V., Pal, M., Gupta, S., Tiwari, S. K., Malkunje, L., & Das, S. (2013). Turmeric-A new treatment option for lichen planus: A pilot study. National Journal of Maxillofacial Surgery, 4(2), 198-201.
Singla, V., Pratap Mouli, V., Garg, S. K., Rai, T., Choudhury, B. N., Verma, P., Deb, R., Tiwari, V., Rohatgi, S., Dhingra, R., & Kedia, S. (2014). Induction with NCB-02 (curcumin) enema for mild-to-moderate distal ulcerative colitis-A randomized, placebo-controlled, pilot study. Journal of Crohn's & Colitis, 8(3), 208-214.
Sivani, B. M., Azzeh, M., Patnaik, R., Pantea Stoian, A., Rizzo, M., & Banerjee, Y. (2022). Reconnoitering the therapeutic role of curcumin in disease prevention and treatment: Lessons learnt and future directions. Metabolites, 12(7), 639.
Small, G. W., Siddarth, P., Li, Z., Miller, K. J., Ercoli, L., Emerson, N. D., Martinez, J., Wong, K. P., Liu, J., Merrill, D. A., & Chen, S. T. (2018). Memory and brain amyloid and tau effects of a bioavailable form of curcumin in non-demented adults: A double-blind, placebo-controlled 18-month trial. The American Journal of Geriatric Psychiatry, 26(3), 266-277.
Sohaei, S., Amani, R., Tarrahi, M. J., & Ghasemi-Tehrani, H. (2019). The effects of curcumin supplementation on glycemic status, lipid profile and hs-CRP levels in overweight/obese women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled clinical trial. Complementary Therapies in Medicine, 47, 102201.
Soni, K., & Kutian, R. (1992). Effet of oral curcumin administration on serum peroxides and cholesterol levels in human volunteers. Indian Journal of Physiology and Pharmacology, 36(4), 273-275.
Sreedhar, A., Sarkar, I., Rajan, P., Pai, J., Malagi, S., Kamath, V., & Barmappa, R. (2015). Comparative evaluation of the efficacy of curcumin gel with and without photo activation as an adjunct to scaling and root planing in the treatment of chronic periodontitis: A split mouth clinical and microbiological study. Journal of Natural Science, Biology, and Medicine, 6, S102-S109.
Srivastava, S., Saksena, A. K., Khattri, S., Kumar, S., & Dagur, R. S. (2016). Curcuma longa extract reduces inflammatory and oxidative stress biomarkers in osteoarthritis of knee: A four-month, double-blind, randomized, placebo-controlled trial. Inflammopharmacology, 24, 377-388.
Steigerwalt, R., Nebbioso, M., Appendino, G., Belcaro, G., Ciammaichella, G., Cornelli, U., Luzzi, R., Togni, S., Dugall, M., Cesarone, M. R., & Ippolito, E. (2012). Meriva®, a lecithinized curcumin delivery system, in diabetic microangiopathy and retinopathy. Panminerva Medica, 54(4), 11.
Sterzi, S., Giordani, L., Morrone, M., Lena, E., Magrone, G., Scarpini, C., Milighetti, S., Pellicciari, L., Bravi, M., Panni, I., & Ljoka, C. (2016). The efficacy and safety of a combination of glucosamine hydrochloride, chondroitin sulfate and bio-curcumin with exercise in the treatment of knee osteoarthritis: A randomized, double-blind, placebo-controlled study. European Journal of Physical and Rehabilitation Medicine, 52(3), 321-330.
Storka, A., Vcelar, B., Klickovic, U., Gouya, G., Weisshaar, S., Aschauer, S., Bolger, G., Helson, L., & Woltz, M. (2015). Safety, tolerability and pharmacokinetics of liposomal curcumin (Lipocurc™) in healthy humans. International Journal of Clinical Pharmacology and Therapeutics, 53(1), 54-65.
Sugawara, J., Akazawa, N., Miyaki, A., Choi, Y., Tanabe, Y., Imai, T., & Maeda, S. (2012). Effect of endurance exercise training and curcumin intake on central arterial hemodynamics in postmenopausal women: Pilot study. American Journal of Hypertension, 25(6), 651-656.
Suhag, A., Dixit, J., & Dhan, P. (2007). Role of curcumin as a subgingival irrigant: A pilot study. Periodontal Practice Today, 4(2), 115-121.
Suskind, D. L., Wahbeh, G., Burpee, T., Cohen, M., Christie, D., & Weber, W. (2013). Tolerability of curcumin in pediatric inflammatory bowel disease: A forced dose titration study. Journal of Pediatric Gastroenterology and Nutrition, 56(3), 277-279.
Tak, K., Sharma, P., Sharma, R., Dave, V., Jain, S., & Sharma, S. (2022). One-pot hydrothermal green synthesis of Polygala tenuifolia mediated graphene quantum dots for acetylcholine esterase inhibitory activity. Journal of Drug Delivery Science and Technology, 73, 103486.
Takahashi, M., Suzuki, K., Kim, H. K., Otsuka, Y., Imaizumi, A., Miyashita, M., & Sakamoto, S. (2014). Effects of curcumin supplementation on exercise-induced oxidative stress in humans. International Journal of Sports Medicine, 35(6), 469-475.
Thomas, A. E., Varma, B., Kurup, S., Jose, R., Chandy, M. L., Kumar, S. P., Aravind, M. S., & Ramadas, A. A. (2017). Evaluation of efficacy of 1% curcuminoids as local application in management of oral lichen planus-Interventional study. Journal of Clinical and Diagnostic Research, 11(4), ZC89-ZC93.
Thomas, R., Williams, M., Sharma, H., Chaudry, A., & Bellamy, P. (2014). A double-blind, placebo-controlled randomised trial evaluating the effect of a polyphenol-rich whole food supplement on PSA progression in men with prostate cancer-The UK NCRN Pomi-T study. Prostate Cancer and Prostatic Diseases, 17(2), 180-186.
Usharani, P., Mateen, A. A., Naidu, M. U., Raju, Y. S., & Chandra, N. (2008). Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: A randomized, parallel-group, placebo-controlled, 8-week study. Drugs in R&D, 9, 243-250.
Vadhan-Raj, S., Weber, D. M., Wang, M., Giralt, S. A., Thomas, S. K., Alexanian, R., Zhou, X., Patel, P., Bueso-Ramos, C. E., Newman, R. A., & Aggarwal, B. B. (2007). Curcumin downregulates NF-kB and related genes in patients with multiple myeloma: Results of a phase I/II study. Blood, 110(11), 1177.
Waghmare, P. F., Chaudhari, A. U., Karhadkar, V. M., & Jamkhande, A. S. (2011). Comparative evaluation of turmeric and chlorhexidine gluconate mouthwash in prevention of plaque formation and gingivitis: A clinical and microbiological study. The Journal of Contemporary Dental Practice, 12(4), 221-224.
West, K. (2013). Topical curcumin for the prevention of oral mucositis in pediatric patients. Alternative Therapies in Health and Medicine, 19(3), 21-24.
Wickenberg, J., Ingemansson, S. L., & Hlebowicz, J. (2010). Effects of Curcuma longa (turmeric) on postprandial plasma glucose and insulin in healthy subjects. Nutrition Journal, 9, 1-5.
Xu, X. Y., Meng, X., Li, S., Gan, R. Y., Li, Y., & Li, H. B. (2018). Bioactivity, health benefits, and related molecular mechanisms of curcumin: Current progress, challenges, and perspectives. Nutrients, 10(10), 1553.
Yadav, M., Aravinda, K., Saxena, V. S., Srinivas, K., Ratnakar, P., Gupta, J., Sachdev, A. S., & Shivhare, P. (2014). Comparison of curcumin with intralesional steroid injections in oral submucous fibrosis-A randomized, open-label interventional study. Journal of Oral Biology and Craniofacial Research, 4(3), 169-173.
Yang, Y. S., Su, Y. F., Yang, H. W., Lee, Y. H., Chou, J. I., & Ueng, K. C. (2014). Lipid-lowering effects of curcumin in patients with metabolic syndrome: A randomized, double-blind, placebo-controlled trial. Phytotherapy Research, 28(12), 1770-1777.
Yang, Z. J., Huang, S. Y., Zhou, D. D., Xiong, R. G., Zhao, C. N., Fang, A. P., Zhang, Y. J., Li, H. B., & Zhu, H. L. (2022). Effects and mechanisms of curcumin for the prevention and management of cancers: An updated review. Antioxidants, 11(8), 1481.
Yanpanitch, O. U., Hatairaktham, S., Charoensakdi, R., Panichkul, N., Fucharoen, S., Srichairatanakool, S., Siritanaratkul, N., & Kalpravidh, R. W. (2015). Treatment of β-thalassemia/hemoglobin E with antioxidant cocktails results in decreased oxidative stress, increased hemoglobin concentration, and improvement of the hypercoagulable state. Oxidative Medicine and Cellular Longevity, 2015, 537954.
Yu, J. J., Pei, L. B., Zhang, Y., Wen, Z. Y., & Yang, J. L. (2015). Chronic supplementation of curcumin enhances the efficacy of antidepressants in major depressive disorder: A randomized, double-blind, placebo-controlled pilot study. Journal of Clinical Psychopharmacology, 35(4), 406-410.
Zhang, J., Huang, Y., Xu, J., Zhao, R., Xiong, C., Habu, J., Wang, Y., & Luo, X. (2022). Global publication trends and research hotspots of curcumin application in tumor: A 20-year bibliometric approach. Frontiers in Oncology, 12, 1033683.
Zuccotti, G. V., Trabattoni, D., Morelli, M., Borgonovo, S., Schneider, L., & Clerici, M. (2009). Immune modulation by lactoferrin and curcumin in children with recurrent respiratory infections. Journal of Biological Regulators and Homeostatic Agents, 23(2), 119-123.