Adverse childhood experiences, the risk of pregnancy complications and adverse pregnancy outcomes: a systematic review and meta-analysis.
adverse events
diabetes in pregnancy
epidemiology
prenatal diagnosis
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
03 08 2023
03 08 2023
Historique:
medline:
7
8
2023
pubmed:
4
8
2023
entrez:
3
8
2023
Statut:
epublish
Résumé
Adverse childhood experiences (ACEs) have a profound negative impact on health. However, the strength of the association between ACEs and pregnancy complications and adverse pregnancy outcomes is not well quantified or understood. To conduct a systematic review and meta-analysis of the association between ACEs and risk of pregnancy complications and adverse pregnancy outcomes. A comprehensive search was conducted using PubMed, Embase, CINAHL, PsycINFO, ClinicalTrials.gov and Google scholar up to July 2022. Two reviewers independently conducted the screening and quality appraisal using a validated tool. Meta-analysis using the quality-effects model on the reported odds ratio (OR) was conducted. Heterogeneity and inconsistency were examined using the I 32 studies from 1508 met a priori inclusion criteria for systematic review, with 21 included in the meta-analysis. Pooled analyses showed that exposure to ACEs increased the risk of pregnancy complications (OR 1.37, 95% CI 1.20 to 1.57) and adverse pregnancy outcomes (OR 1.31, 95% CI 1.17 to 1.47). In sub-group analysis, maternal ACEs were associated with gestational diabetes mellitus (OR 1.39, 95% CI 1.11 to 1.74), antenatal depression (OR 1.59, 95% CI 1.15 to 2.20), low offspring birth weight (OR 1.27, 95% CI 1.02 to 1.47), and preterm delivery (OR 1.41, 95% CI 1.16 to 1.71). The results suggest that exposure to ACEs increases the risk of pregnancy complications and adverse pregnancy outcomes. Preventive strategies, screening and trauma-informed care need to be examined to improve maternal and child health.
Sections du résumé
BACKGROUND
Adverse childhood experiences (ACEs) have a profound negative impact on health. However, the strength of the association between ACEs and pregnancy complications and adverse pregnancy outcomes is not well quantified or understood.
OBJECTIVE
To conduct a systematic review and meta-analysis of the association between ACEs and risk of pregnancy complications and adverse pregnancy outcomes.
SEARCH STRATEGY
A comprehensive search was conducted using PubMed, Embase, CINAHL, PsycINFO, ClinicalTrials.gov and Google scholar up to July 2022.
DATA COLLECTION AND ANALYSIS
Two reviewers independently conducted the screening and quality appraisal using a validated tool. Meta-analysis using the quality-effects model on the reported odds ratio (OR) was conducted. Heterogeneity and inconsistency were examined using the I
RESULTS
32 studies from 1508 met a priori inclusion criteria for systematic review, with 21 included in the meta-analysis. Pooled analyses showed that exposure to ACEs increased the risk of pregnancy complications (OR 1.37, 95% CI 1.20 to 1.57) and adverse pregnancy outcomes (OR 1.31, 95% CI 1.17 to 1.47). In sub-group analysis, maternal ACEs were associated with gestational diabetes mellitus (OR 1.39, 95% CI 1.11 to 1.74), antenatal depression (OR 1.59, 95% CI 1.15 to 2.20), low offspring birth weight (OR 1.27, 95% CI 1.02 to 1.47), and preterm delivery (OR 1.41, 95% CI 1.16 to 1.71).
CONCLUSION
The results suggest that exposure to ACEs increases the risk of pregnancy complications and adverse pregnancy outcomes. Preventive strategies, screening and trauma-informed care need to be examined to improve maternal and child health.
Identifiants
pubmed: 37536966
pii: bmjopen-2022-063826
doi: 10.1136/bmjopen-2022-063826
pmc: PMC10401231
doi:
Types de publication
Meta-Analysis
Systematic Review
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e063826Informations de copyright
© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
J Clin Med. 2018 May 23;7(6):
pubmed: 29882903
Midwifery. 2015 Jan;31(1):54-60
pubmed: 24929272
Adv Exp Med Biol. 2017;978:93-103
pubmed: 28523542
Int J Evid Based Healthc. 2018 Dec;16(4):195-203
pubmed: 29621038
Pediatrics. 2018 Jun;141(6):
pubmed: 29784755
JAMA. 2000 Apr 19;283(15):2008-12
pubmed: 10789670
J Abnorm Psychol. 2017 Feb;126(2):173-183
pubmed: 27935730
AIDS Behav. 2020 Jun;24(6):1643-1652
pubmed: 31542877
Arch Pediatr Adolesc Med. 2010 Jun;164(6):533-9
pubmed: 20530303
Pediatr Ann. 2019 Jul 1;48(7):e257-e261
pubmed: 31305942
BMC Pregnancy Childbirth. 2021 Sep 23;21(1):648
pubmed: 34556095
Child Abuse Negl. 2019 Nov;97:104127
pubmed: 31454589
BMC Pregnancy Childbirth. 2021 Apr 27;21(1):335
pubmed: 33906618
J Pediatr Psychol. 2007 Nov-Dec;32(10):1238-48
pubmed: 17569710
J Epidemiol Community Health. 2003 Oct;57(10):778-83
pubmed: 14573579
Child Abuse Negl. 2018 Apr;78:19-30
pubmed: 28992958
PLoS One. 2015 Jan 30;10(1):e0116609
pubmed: 25635902
Endocr Regul. 2019 Oct 1;53(4):213-220
pubmed: 31734655
Am J Prev Med. 2016 Apr;50(4):463-469
pubmed: 26558699
Diabetes. 2020 Aug;69(8):1662-1674
pubmed: 32409491
J Obstet Gynecol Neonatal Nurs. 2018 Nov;47(6):783-794
pubmed: 30308147
J Dev Orig Health Dis. 2019 Feb;10(1):88-99
pubmed: 30175696
BMC Pregnancy Childbirth. 2019 Oct 28;19(1):387
pubmed: 31660899
BMJ. 2015 Jan 02;350:g7647
pubmed: 25555855
J Womens Health (Larchmt). 2019 Apr;28(4):452-461
pubmed: 30183473
J Health Psychol. 2020 Mar;25(4):545-557
pubmed: 28810501
J Public Health (Oxf). 2022 Dec 1;44(4):810-822
pubmed: 34231848
Matern Child Health J. 2019 Mar;23(3):408-415
pubmed: 30627949
Am J Prev Med. 2019 Sep;57(3):302-310
pubmed: 31353162
BMC Pregnancy Childbirth. 2018 Oct 16;18(1):404
pubmed: 30326858
J Glob Health. 2019 Dec;9(2):020435
pubmed: 31893035
Aust N Z J Obstet Gynaecol. 2022 Oct;62(5):626-634
pubmed: 35909247
Physiol Behav. 2012 Apr 12;106(1):29-39
pubmed: 21888923
Psychoneuroendocrinology. 2017 Oct;84:32-41
pubmed: 28651102
BMC Pregnancy Childbirth. 2015 Aug 15;15:174
pubmed: 26276498
Lancet Diabetes Endocrinol. 2015 Oct;3(10):767-77
pubmed: 26165396
Soc Sci Med. 2017 Aug;186:20-33
pubmed: 28577458
Obes Rev. 2021 Jul;22(7):e13204
pubmed: 33506595
Child Abuse Negl. 2018 Nov;85:145-155
pubmed: 29478731
J Psychosom Res. 2006 Aug;61(2):139-51
pubmed: 16880016
BMC Pregnancy Childbirth. 2022 Feb 16;22(1):129
pubmed: 35172776
BMC Pregnancy Childbirth. 2015 Aug 26;15:194
pubmed: 26306798
Ann Epidemiol. 2020 Oct;50:1-6
pubmed: 32791197
JAMA. 2020 Jun 16;323(23):2379-2380
pubmed: 32463425
BMJ Paediatr Open. 2019 Mar 08;3(1):e000330
pubmed: 30957023
J Perinat Med. 2014 Mar;42(2):171-8
pubmed: 24334452
Matern Child Health J. 2021 Oct;25(10):1581-1594
pubmed: 34036452
Matern Child Health J. 2016 Apr;20(4):790-8
pubmed: 26762511
Brain Behav Immun. 2017 Oct;65:11-19
pubmed: 28450221
BMC Med. 2015 Jun 11;13:124
pubmed: 26063042
Curr Opin Psychiatry. 2012 Mar;25(2):141-8
pubmed: 22262028
Am J Prev Med. 2022 Jun;62(6 Suppl 1):S1-S5
pubmed: 35597578
Front Hum Neurosci. 2012 Mar 22;6:51
pubmed: 22461773
J Epidemiol Community Health. 2016 Jun;70(6):589-95
pubmed: 26957551
BMC Psychiatry. 2021 Jan 11;21(1):28
pubmed: 33430822
J Fam Psychol. 2019 Apr;33(3):304-314
pubmed: 30802085
BMC Pregnancy Childbirth. 2011 Oct 26;11:79
pubmed: 22026403
Brain Behav Immun. 2019 Jan;75:240-250
pubmed: 30399404
Am J Prev Med. 2016 Apr;50(4):436-444
pubmed: 26547539
Psychiatry Res. 2018 Feb;260:458-467
pubmed: 29272731
JAMA Pediatr. 2015 Mar;169(3):211-9
pubmed: 25622303
Biol Psychiatry. 2016 Jul 1;80(1):23-32
pubmed: 26166230
Am J Prev Med. 1998 May;14(4):245-58
pubmed: 9635069
Can Rev Sociol. 2012 Feb;49(1):50-68
pubmed: 22586837
PLoS One. 2012;7(12):e51868
pubmed: 23300572
Child Abuse Negl. 1999 Jan;23(1):81-90
pubmed: 10075195
Neuropsychopharmacology. 2016 Jan;41(1):177-96
pubmed: 26334107
Res Synth Methods. 2017 Mar;8(1):5-18
pubmed: 28058794
R I Med J (2013). 2020 Nov 2;103(9):52-55
pubmed: 33126790
Child Maltreat. 2016 Nov;21(4):317-326
pubmed: 27457410
Psychoneuroendocrinology. 2020 Mar;113:104484
pubmed: 31918390
Br J Pharmacol. 2019 Jun;176(12):1914-1921
pubmed: 30095157
J Affect Disord. 2020 Feb 15;263:576-581
pubmed: 31759669
J Affect Disord. 2020 Apr 15;267:49-56
pubmed: 32063572
Lancet Public Health. 2017 Aug;2(8):e356-e366
pubmed: 29253477
Psychoneuroendocrinology. 2017 Aug;82:140-154
pubmed: 28549270