PET assessment of acute gastrointestinal graft versus host disease.


Journal

Bone marrow transplantation
ISSN: 1476-5365
Titre abrégé: Bone Marrow Transplant
Pays: England
ID NLM: 8702459

Informations de publication

Date de publication:
09 2023
Historique:
received: 15 05 2023
accepted: 07 07 2023
revised: 29 06 2023
medline: 4 9 2023
pubmed: 4 8 2023
entrez: 3 8 2023
Statut: ppublish

Résumé

Acute gastrointestinal graft versus host disease (GI-GVHD) is a common complication following allogeneic haematopoietic cell transplantation (HCT), and is characterised by severe morbidity, frequent treatment-refractoriness, and high mortality. Early, accurate identification of GI-GVHD could allow for therapeutic interventions to ameliorate its severity, improve response rates and survival; however, standard endoscopic biopsy is inadequately informative in terms of diagnostic sensitivity or outcome prediction. In an era where rapid technological and laboratory advances have dramatically expanded our understanding of GI-GVHD biology and potential therapeutic targets, there is substantial scope for novel investigations that can precisely guide GI-GVHD management. In particular, the combination of tissue-based biomarker assessment (plasma cytokines, faecal microbiome) and molecular imaging by positron emission tomography (PET) offers the potential for non-invasive, real-time in vivo assessment of donor:recipient immune activity within the GI tract for GI-GVHD prediction or diagnosis. In this article, we review the evidence regarding GI-GVHD diagnosis, and examine the potential roles and translational opportunities posed by these novel diagnostic tools, with a focus on the evolving role of PET.

Identifiants

pubmed: 37537245
doi: 10.1038/s41409-023-02038-9
pii: 10.1038/s41409-023-02038-9
pmc: PMC10471499
doi:

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

973-979

Informations de copyright

© 2023. Crown.

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Auteurs

Ashleigh P Scott (AP)

Department of Haematology and Bone Marrow Transplant, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia. Ashleigh.scott@health.qld.gov.au.
School of Medicine, The University of Queensland, Brisbane, QLD, Australia. Ashleigh.scott@health.qld.gov.au.

Andrea Henden (A)

Department of Haematology and Bone Marrow Transplant, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.
School of Medicine, The University of Queensland, Brisbane, QLD, Australia.
QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

Glen A Kennedy (GA)

Department of Haematology and Bone Marrow Transplant, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.
School of Medicine, The University of Queensland, Brisbane, QLD, Australia.

Siok-Keen Tey (SK)

Department of Haematology and Bone Marrow Transplant, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.
School of Medicine, The University of Queensland, Brisbane, QLD, Australia.
QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

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