SERCA2 regulates proinsulin processing and processing enzyme maturation in pancreatic beta cells.
Beta cell biology
Calcium imaging
Calcium signalling
Endoplasmic reticulum
Insulin secretion
Insulin synthesis
Proinsulin processing
Protein trafficking
Journal
Diabetologia
ISSN: 1432-0428
Titre abrégé: Diabetologia
Pays: Germany
ID NLM: 0006777
Informations de publication
Date de publication:
11 2023
11 2023
Historique:
received:
14
02
2023
accepted:
13
06
2023
medline:
2
10
2023
pubmed:
4
8
2023
entrez:
3
8
2023
Statut:
ppublish
Résumé
Increased circulating levels of incompletely processed insulin (i.e. proinsulin) are observed clinically in type 1 and type 2 diabetes. Previous studies have suggested that Ca We generated mice with beta cell-specific sarcoendoplasmic reticulum Ca βS2KO mice exhibited age-dependent glucose intolerance and increased plasma and pancreatic levels of proinsulin, while endoplasmic reticulum (ER) Ca Taken together, these data highlight an important link between ER Ca RNA-seq data have been deposited in the Gene Expression Omnibus (GEO; accession no.: GSE207498).
Identifiants
pubmed: 37537395
doi: 10.1007/s00125-023-05979-4
pii: 10.1007/s00125-023-05979-4
pmc: PMC10542743
mid: NIHMS1931695
doi:
Substances chimiques
Proinsulin
9035-68-1
Sarcoplasmic Reticulum Calcium-Transporting ATPases
EC 3.6.3.8
Insulin
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
2042-2061Subventions
Organisme : NIDDK NIH HHS
ID : U01 DK127786
Pays : United States
Organisme : BLRD VA
ID : I01 BX001733
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA042351
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK048280
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK127236
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK097512
Pays : United States
Organisme : NIDDK NIH HHS
ID : F31 DK134168
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK101001
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA042351
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK093954
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK0604466
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK127308
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK104166
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK127747
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002529
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM077229
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM148382
Pays : United States
Informations de copyright
© 2023. The Author(s).
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