Implementing an Evidence-Based COPD Hospital Discharge Protocol: A Narrative Review and Expert Recommendations.
Care bundles
Chronic obstructive pulmonary disease
Discharge protocol
Exacerbation
Hospital readmission
Implementation strategies
Journal
Advances in therapy
ISSN: 1865-8652
Titre abrégé: Adv Ther
Pays: United States
ID NLM: 8611864
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
31
05
2023
accepted:
06
07
2023
medline:
14
9
2023
pubmed:
4
8
2023
entrez:
3
8
2023
Statut:
ppublish
Résumé
Discharge bundles, comprising evidence-based practices to be implemented prior to discharge, aim to optimise patient outcomes. They have been recommended to address high readmission rates in patients who have been hospitalised for an exacerbation of chronic obstructive pulmonary disease (COPD). Hospital readmission is associated with increased morbidity and healthcare resource utilisation, contributing substantially to the economic burden of COPD. Previous studies suggest that COPD discharge bundles may result in fewer hospital readmissions, lower risk of mortality and improvement of patient quality of life. However, evidence for their effectiveness is inconsistent, likely owing to variable content and implementation of these bundles. To ensure consistent provision of high-quality care for patients hospitalised with an exacerbation of COPD and reduce readmission rates following discharge, we propose a comprehensive discharge protocol, and provide evidence highlighting the importance of each element of the protocol. We then review care bundles used in COPD and other disease areas to understand how they affect patient outcomes, the barriers to implementing these bundles and what strategies have been used in other disease areas to overcome these barriers. We identified four evidence-based care bundle items for review prior to a patient's discharge from hospital, including (1) smoking cessation and assessment of environmental exposures, (2) treatment optimisation, (3) pulmonary rehabilitation, and (4) continuity of care. Resource constraints, lack of staff engagement and knowledge, and complexity of the COPD population were some of the key barriers inhibiting effective bundle implementation. These barriers can be addressed by applying learnings on successful bundle implementation from other disease areas, such as healthcare practitioner education and audit and feedback. By utilising the relevant implementation strategies, discharge bundles can be more (cost-)effectively delivered to improve patient outcomes, reduce readmission rates and ensure continuity of care for patients who have been discharged from hospital following a COPD exacerbation.
Identifiants
pubmed: 37537515
doi: 10.1007/s12325-023-02609-8
pii: 10.1007/s12325-023-02609-8
pmc: PMC10499689
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
4236-4263Informations de copyright
© 2023. The Author(s).
Références
Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease report [Internet]. 2023 [cited 2023 May 13]. Available from: https://goldcopd.org/wp-content/uploads/2022/12/GOLD-2023-ver-1.1-2Dec2022_WMV.pdf
Celli B, Fabbri L, Criner G, Martinez FJ, Mannino D, Vogelmeier C, et al. Definition and nomenclature of chronic obstructive pulmonary disease: time for its revision. Am J Respir Crit Care Med. 2022;206:1317–25.
pubmed: 35914087
pmcid: 9746870
doi: 10.1164/rccm.202204-0671PP
World Health Organization. Chronic obstructive pulmonary disease (COPD) [Internet]. 2023 [cited 2023 May 13]. Available from: https://www.who.int/news-room/fact-sheets/detail/chronic-obstructive-pulmonary-disease-(copd) .
Adeloye D, Song P, Zhu Y, Campbell H, Sheikh A, Rudan I, et al. Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2019: a systematic review and modelling analysis. Lancet Respir Med. 2022;10:447–58.
pubmed: 35279265
pmcid: 9050565
doi: 10.1016/S2213-2600(21)00511-7
Tashkin DP, Celli B, Senn S, Burkhart D, Kesten S, Menjoge S, et al. A 4-year trial of tiotropium in chronic obstructive pulmonary disease. N Engl J Med. 2008;359:1543–54.
pubmed: 18836213
doi: 10.1056/NEJMoa0805800
Suissa S, Dell’Aniello S, Ernst P. Long-term natural history of chronic obstructive pulmonary disease: severe exacerbations and mortality. Thorax. 2012;67:957–63.
pubmed: 22684094
doi: 10.1136/thoraxjnl-2011-201518
Donaldson GC, Hurst JR, Smith CJ, Hubbard RB, Wedzicha JA. Increased risk of myocardial infarction and stroke following exacerbation of COPD. Chest. 2010;137:1091–7.
pubmed: 20022970
doi: 10.1378/chest.09-2029
Watz H, Tetzlaff K, Magnussen H, Mueller A, Rodriguez-Roisin R, Wouters EF, et al. Spirometric changes during exacerbations of COPD: a post hoc analysis of the WISDOM trial. Respir Res. 2018;19:251.
pubmed: 30545350
pmcid: 6293570
doi: 10.1186/s12931-018-0944-3
Mittmann N, Kuramoto L, Seung SJ, Haddon JM, Bradley-Kennedy C, Fitzgerald JM. The cost of moderate and severe COPD exacerbations to the Canadian healthcare system. Respir Med. 2008;102:413–21.
pubmed: 18086519
doi: 10.1016/j.rmed.2007.10.010
Matkovic Z, Huerta A, Soler N, Domingo R, Gabarrús A, Torres A, et al. Predictors of adverse outcome in patients hospitalised for exacerbation of chronic obstructive pulmonary disease. Respiration. 2012;84:17–26.
pubmed: 22327370
doi: 10.1159/000335467
Stone R, Holzhauer-Barrie J, Lowe D, McMillan V, Saleem Khan M, Searle L, et al. COPD: Who cares when it matters most? National Chronic Obstructive Pulmonary Disease (COPD) Programme: outcomes from the clinical audit of COPD exacerbations admitted to acute units in England 2014 [Internet]. 2017 [cited 2023 May 13]. Available from: https://www.rcplondon.ac.uk/projects/outputs/copd-who-cares-when-it-matters-most-outcomes-report-2014
Shah T, Churpek MM, Coca Perraillon M, Konetzka RT. Understanding why patients with COPD get readmitted: a large national study to delineate the Medicare population for the readmissions penalty expansion. Chest. 2015;147:1219–26.
pubmed: 25539483
doi: 10.1378/chest.14-2181
Li J, Liang L, Cao S, Rong H, Feng L, Zhang D, et al. Secular trend and risk factors of 30-day COPD-related readmission in Beijing, China. Sci Rep. 2022;12:16589.
pubmed: 36198705
doi: 10.1038/s41598-022-20884-3
Echevarria C, Steer J, Heslop-Marshall K, Stenton SC, Hickey PM, Hughes R, et al. The PEARL score predicts 90-day readmission or death after hospitalisation for acute exacerbation of COPD. Thorax. 2017;72:686–93.
pubmed: 28235886
doi: 10.1136/thoraxjnl-2016-209298
Seemungal TA, Donaldson GC, Paul EA, Bestall JC, Jeffries DJ, Wedzicha JA. Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1998;157:1418–22.
pubmed: 9603117
doi: 10.1164/ajrccm.157.5.9709032
Langsetmo L, Platt RW, Ernst P, Bourbeau J. Underreporting exacerbation of chronic obstructive pulmonary disease in a longitudinal cohort. Am J Respir Crit Care Med. 2008;177:396–401.
pubmed: 18048806
doi: 10.1164/rccm.200708-1290OC
Xu W, Collet J-P, Shapiro S, Lin Y, Yang T, Wang C, et al. Negative impacts of unreported COPD exacerbations on health-related quality of life at 1 year. Eur Respir J. 2010;35:1022–30.
pubmed: 19897555
doi: 10.1183/09031936.00079409
Price D, West D, Brusselle G, Gruffydd-Jones K, Jones R, Miravitlles M, et al. Management of COPD in the UK primary-care setting: an analysis of real-life prescribing patterns. Int J Chron Obstruct Pulmon Dis. 2014;9:889–904.
pubmed: 25210450
pmcid: 4154894
doi: 10.2147/COPD.S62750
Blanchette CM, Gross NJ, Altman P. Rising costs of COPD and the potential for maintenance therapy to slow the trend. Am Health Drug Benefits. 2014;7:98–106.
pubmed: 24991394
pmcid: 4049119
Shah T, Press VG, Huisingh-Scheetz M, White SR. COPD readmissions: addressing COPD in the era of value-based health care. Chest. 2016;150:916–26.
pubmed: 27167208
pmcid: 5812767
doi: 10.1016/j.chest.2016.05.002
Miravitlles M, García-Polo C, Domenech A, Villegas G, Conget F, de la Roza C. Clinical outcomes and cost analysis of exacerbations in chronic obstructive pulmonary disease. Lung. 2013;191:523–30.
pubmed: 23842641
doi: 10.1007/s00408-013-9487-z
Kong CW, Wilkinson TM. Predicting and preventing hospital readmission for exacerbations of COPD. ERJ Open Res. 2020;6:00325–2019.
pubmed: 32420313
pmcid: 7211949
doi: 10.1183/23120541.00325-2019
Hopkinson NS, Englebretsen C, Cooley N, Kennie K, Lim M, Woodcock T, et al. Designing and implementing a COPD discharge care bundle. Thorax. 2012;67:90–2.
pubmed: 21846790
doi: 10.1136/thoraxjnl-2011-200233
Ospina MB, Mrklas K, Deuchar L, Rowe BH, Leigh R, Bhutani M, et al. A systematic review of the effectiveness of discharge care bundles for patients with COPD. Thorax. 2017;72:31–9.
pubmed: 27613539
doi: 10.1136/thoraxjnl-2016-208820
Westbroek LF, Klijnsma M, Salomé P, Sekhuis LM, Rolink E, Korsmit E, et al. Reducing the number of hospitalization days for COPD: setting up a transmural-care pathway. Int J Chron Obstruct Pulmon Dis. 2020;15:2367–77.
pubmed: 33061354
pmcid: 7533231
doi: 10.2147/COPD.S242914
Miravitlles M, Calle M, Molina J, Almagro P, Gómez J-T, Trigueros JA, et al. Spanish COPD guidelines (GesEPOC) 2021: updated pharmacological treatment of stable COPD. Arch Bronconeumol. 2022;58:69–81.
pubmed: 33840553
doi: 10.1016/j.arbres.2021.03.005
British Thoracic Society (BTS). Chronic obstructive pulmonary disease (COPD) discharge care bundle [Internet]. 2016 [cited 2023 May 13]. Available from: https://www.brit-thoracic.org.uk/quality-improvement/clinical-resources/copd-spirometry/
Lung Foundation Australia. Managing COPD exacerbation checklist [Internet]. 2023 [cited 2023 May 13]. Available from: https://lungfoundation.com.au/resources/managing-copd-exacerbation-checklist/
Warnier MJ, van Riet EE, Rutten FH, De Bruin ML, Sachs AP. Smoking cessation strategies in patients with COPD. Eur Respir J. 2013;41:727–34.
pubmed: 22936706
doi: 10.1183/09031936.00014012
Hoogendoorn M, Feenstra TL, Hoogenveen RT, Rutten-van Mölken MP. Long-term effectiveness and cost-effectiveness of smoking cessation interventions in patients with COPD. Thorax. 2010;65:711–8.
pubmed: 20685746
doi: 10.1136/thx.2009.131631
Dhariwal J, Tennant RC, Hansell DM, Westwick J, Walker C, Ward SP, et al. Smoking cessation in COPD causes a transient improvement in spirometry and decreases micronodules on high-resolution CT imaging. Chest. 2014;145:1006–15.
pubmed: 24522562
pmcid: 4011651
doi: 10.1378/chest.13-2220
Lenferink A, Brusse-Keizer M, van der Valk PD, Frith PA, Zwerink M, Monninkhof EM, et al. Self-management interventions including action plans for exacerbations versus usual care in patients with chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2017;8:CD011682.
pubmed: 28777450
Anthonisen NR, Skeans MA, Wise RA, Manfreda J, Kanner RE, Connett JE, et al. The effects of a smoking cessation intervention on 14.5-year mortality: a randomized clinical trial. Ann Intern Med. 2005;142:233–9.
pubmed: 15710956
doi: 10.7326/0003-4819-142-4-200502150-00005
Au DH, Bryson CL, Chien JW, Sun H, Udris EM, Evans LE, et al. The effects of smoking cessation on the risk of chronic obstructive pulmonary disease exacerbations. J Gen Intern Med. 2009;24:457–63.
pubmed: 19194768
pmcid: 2659150
doi: 10.1007/s11606-009-0907-y
Li J, Sun S, Tang R, Qiu H, Huang Q, Mason TG, et al. Major air pollutants and risk of COPD exacerbations: a systematic review and meta-analysis. Int J Chron Obstruct Pulmon Dis. 2016;11:3079–91.
pubmed: 28003742
pmcid: 5161337
doi: 10.2147/COPD.S122282
Hoffmann C, Maglakelidze M, von Schneidemesser E, Witt C, Hoffmann P, Butler T. Asthma and COPD exacerbation in relation to outdoor air pollution in the metropolitan area of Berlin, Germany. Respir Res. 2022;23:64.
pubmed: 35307034
pmcid: 8935815
doi: 10.1186/s12931-022-01983-1
National Institute for Health and Care Excellence. Chronic obstructive pulmonary disease in over 16s: diagnosis and management [Internet]. 2019 [cited 2023 May 13]. Available from: https://www.nice.org.uk/guidance/ng115/resources/chronic-obstructive-pulmonary-disease-in-over-16s-diagnosis-and-management-pdf-66141600098245
Janson C, Nwaru BI, Wiklund F, Telg G, Ekström M. Management and risk of mortality in patients hospitalised due to a first severe COPD exacerbation. Int J Chron Obstruct Pulmon Dis. 2020;15:2673–82.
pubmed: 33149565
pmcid: 7604260
doi: 10.2147/COPD.S276819
Rabe KF, Martinez FJ, Ferguson GT, Wang C, Singh D, Wedzicha JA, et al. Triple inhaled therapy at two glucocorticoid doses in moderate-to-very-severe COPD. N Engl J Med. 2020;383:35–48.
pubmed: 32579807
doi: 10.1056/NEJMoa1916046
Lipson DA, Barnhart F, Brealey N, Brooks J, Criner GJ, Day NC, et al. Once-daily single-inhaler triple versus dual therapy in patients with COPD. N Engl J Med. 2018;378:1671–80.
pubmed: 29668352
doi: 10.1056/NEJMoa1713901
Tkacz J, Evans KA, Touchette DR, Portillo E, Strange C, Staresinic A, et al. PRIMUS–Prompt Initiation of Maintenance Therapy in the US: a real-world analysis of clinical and economic outcomes among patients initiating triple therapy following a COPD exacerbation. Int J Chron Obstruct Pulmon Dis. 2022;17:329–42.
pubmed: 35177901
pmcid: 8843423
doi: 10.2147/COPD.S347735
Miravitlles M, D’Urzo A, Singh D, Koblizek V. Pharmacological strategies to reduce exacerbation risk in COPD: a narrative review. Respir Res. 2016;17:112.
pubmed: 27613392
pmcid: 5018159
doi: 10.1186/s12931-016-0425-5
Anzueto A. Impact of exacerbations on COPD. Eur Respir Rev. 2010;19:113–8.
pubmed: 20956179
pmcid: 9682573
doi: 10.1183/09059180.00002610
Bhutani M, Price DB, Winders TA, Worth H, Gruffydd-Jones K, Tal-Singer R, et al. Quality standard position statements for health system policy changes in diagnosis and management of COPD: a global perspective. Adv Ther. 2022;39:2302–22.
pubmed: 35482251
pmcid: 9047462
doi: 10.1007/s12325-022-02137-x
Bhattarai B, Walpola R, Mey A, Anoopkumar-Dukie S, Khan S. Barriers and strategies for improving medication adherence among people living with COPD: a systematic review. Respir Care. 2020;65:1738–50.
pubmed: 32576706
doi: 10.4187/respcare.07355
Dickens C, Katon W, Blakemore A, Khara A, Tomenson B, Woodcock A, et al. Complex interventions that reduce urgent care use in COPD: a systematic review with meta-regression. Respir Med. 2014;108:426–37.
pubmed: 23806286
doi: 10.1016/j.rmed.2013.05.011
Bourbeau J, Julien M, Maltais F, Rouleau M, Beaupré A, Bégin R, et al. Reduction of hospital utilization in patients with chronic obstructive pulmonary disease: a disease-specific self-management intervention. Arch Intern Med. 2003;163:585–91.
pubmed: 12622605
doi: 10.1001/archinte.163.5.585
Roberts NJ, Ghiassi R, Partridge MR. Health literacy in COPD. Int J Chron Obstruct Pulmon Dis. 2008;3:499–507.
pubmed: 19281068
pmcid: 2650589
Lavorini F, Magnan A, Christophe Dubus J, Voshaar T, Corbetta L, Broeders M, et al. Effect of incorrect use of dry powder inhalers on management of patients with asthma and COPD. Respir Med. 2008;102:593–604.
pubmed: 18083019
doi: 10.1016/j.rmed.2007.11.003
Melani AS, Bonavia M, Cilenti V, Cinti C, Lodi M, Martucci P, et al. Inhaler mishandling remains common in real life and is associated with reduced disease control. Respir Med. 2011;105:930–8.
pubmed: 21367593
doi: 10.1016/j.rmed.2011.01.005
van Boven JF, Chavannes NH, van der Molen T, Rutten-van Mölken MP, Postma MJ, Vegter S. Clinical and economic impact of non-adherence in COPD: a systematic review. Respir Med. 2014;108:103–13.
pubmed: 24070566
doi: 10.1016/j.rmed.2013.08.044
Gershon AS, McGihon RE, Thiruchelvam D, To T, Wu R, Bell CM, et al. Medication discontinuation in adults with COPD discharged from the hospital: a population-based cohort study. Chest. 2021;159:975–84.
pubmed: 33011204
doi: 10.1016/j.chest.2020.09.254
Usmani OS. Choosing the right inhaler for your asthma or COPD patient. Ther Clin Risk Manag. 2019;15:461–72.
pubmed: 30936708
pmcid: 6422419
doi: 10.2147/TCRM.S160365
Baloira A, Abad A, Fuster A, García Rivero JL, García-Sidro P, Márquez-Martín E, et al. Lung deposition and inspiratory flow rate in patients with chronic obstructive pulmonary disease using different inhalation devices: a systematic literature review and expert opinion. Int J Chron Obstruct Pulmon Dis. 2021;16:1021–33.
pubmed: 33907390
pmcid: 8064620
doi: 10.2147/COPD.S297980
Jia X, Zhou S, Luo D, Zhao X, Zhou Y, Cui Y-M. Effect of pharmacist-led interventions on medication adherence and inhalation technique in adult patients with asthma or COPD: a systematic review and meta-analysis. J Clin Pharm Ther. 2020;45:904–17.
pubmed: 32107837
doi: 10.1111/jcpt.13126
Tommelein E, Mehuys E, Van Hees T, Adriaens E, Van Bortel L, Christiaens T, et al. Effectiveness of pharmaceutical care for patients with chronic obstructive pulmonary disease (PHARMACOP): a randomized controlled trial. Br J Clin Pharmacol. 2014;77:756–66.
pubmed: 24117908
pmcid: 4004396
doi: 10.1111/bcp.12242
van Boven JF, Tommelein E, Boussery K, Mehuys E, Vegter S, Brusselle GG, et al. Improving inhaler adherence in patients with chronic obstructive pulmonary disease: a cost-effectiveness analysis. Respir Res. 2014;15:66.
pubmed: 24929799
pmcid: 4067522
doi: 10.1186/1465-9921-15-66
Davies L, Angus RM, Calverley PM. Oral corticosteroids in patients admitted to hospital with exacerbations of chronic obstructive pulmonary disease: a prospective randomised controlled trial. Lancet. 1999;354:456–60.
pubmed: 10465169
doi: 10.1016/S0140-6736(98)11326-0
Niewoehner DE, Erbland ML, Deupree RH, Collins D, Gross NJ, Light RW, et al. Effect of systemic glucocorticoids on exacerbations of chronic obstructive pulmonary disease. Department of Veterans Affairs Cooperative Study Group. N Engl J Med. 1999;340:1941–7.
pubmed: 10379017
doi: 10.1056/NEJM199906243402502
Aaron SD, Vandemheen KL, Hebert P, Dales R, Stiell IG, Ahuja J, et al. Outpatient oral prednisone after emergency treatment of chronic obstructive pulmonary disease. N Engl J Med. 2003;348:2618–25.
pubmed: 12826636
doi: 10.1056/NEJMoa023161
Wedzicha JA, Miravitlles M, Hurst JR, Calverley PM, Albert RK, Anzueto A, et al. Management of COPD exacerbations: a European Respiratory Society/American Thoracic Society guideline. Eur Respir J. 2017;49:1600791.
pubmed: 28298398
doi: 10.1183/13993003.00791-2016
Sivapalan P, Ingebrigtsen TS, Rasmussen DB, Sørensen R, Rasmussen CM, Jensen CB, et al. COPD exacerbations: the impact of long versus short courses of oral corticosteroids on mortality and pneumonia: nationwide data on 67 000 patients with COPD followed for 12 months. BMJ Open Respir Res. 2019;6:e000407.
pubmed: 31179005
pmcid: 6530506
doi: 10.1136/bmjresp-2019-000407
McCarthy B, Casey D, Devane D, Murphy K, Murphy E, Lacasse Y. Pulmonary rehabilitation for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2015;2015:CD003793.
Lindenauer PK, Stefan MS, Pekow PS, Mazor KM, Priya A, Spitzer KA, et al. Association between initiation of pulmonary rehabilitation after hospitalization for COPD and 1-year survival among Medicare beneficiaries. JAMA. 2020;323:1813–23.
pubmed: 32396181
doi: 10.1001/jama.2020.4437
Stefan MS, Pekow PS, Priya A, ZuWallack R, Spitzer KA, Lagu TC, et al. Association between initiation of pulmonary rehabilitation and rehospitalizations in patients hospitalized with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2021;204:1015–23.
pubmed: 34283694
pmcid: 8663014
doi: 10.1164/rccm.202012-4389OC
Ryrsø CK, Godtfredsen NS, Kofod LM, Lavesen M, Mogensen L, Tobberup R, et al. Lower mortality after early supervised pulmonary rehabilitation following COPD-exacerbations: a systematic review and meta-analysis. BMC Pulm Med. 2018;18:154.
pubmed: 30219047
pmcid: 6139159
doi: 10.1186/s12890-018-0718-1
Bickton FM, Shannon H. Barriers and enablers to pulmonary rehabilitation in low- and middle-income countries: a qualitative study of healthcare professionals. Int J Chron Obstruct Pulmon Dis. 2022;17:141–53.
pubmed: 35046649
pmcid: 8763198
doi: 10.2147/COPD.S348663
Jones SE, Green SA, Clark AL, Dickson MJ, Nolan A-M, Moloney C, et al. Pulmonary rehabilitation following hospitalisation for acute exacerbation of COPD: referrals, uptake and adherence. Thorax. 2014;69:181–2.
pubmed: 23945168
doi: 10.1136/thoraxjnl-2013-204227
Cox M, O’Connor C, Biggs K, Hind D, Bortolami O, Franklin M, et al. The feasibility of early pulmonary rehabilitation and activity after COPD exacerbations: external pilot randomised controlled trial, qualitative case study and exploratory economic evaluation. Health Technol Assess. 2018;22:1–204.
pubmed: 29516853
pmcid: 5867394
doi: 10.3310/hta22110
Lahham A, Holland AE. The need for expanding pulmonary rehabilitation services. Life. 2021;11:1236.
pubmed: 34833112
pmcid: 8622005
doi: 10.3390/life11111236
Gimeno-Santos E, Frei A, Steurer-Stey C, de Batlle J, Rabinovich RA, Raste Y, et al. Determinants and outcomes of physical activity in patients with COPD: a systematic review. Thorax. 2014;69:731–9.
pubmed: 24558112
doi: 10.1136/thoraxjnl-2013-204763
Donaire-Gonzalez D, Gimeno-Santos E, Balcells E, de Batlle J, Ramon MA, Rodriguez E, et al. Benefits of physical activity on COPD hospitalisation depend on intensity. Eur Respir J. 2015;46:1281–9.
pubmed: 26206873
doi: 10.1183/13993003.01699-2014
Collins PF, Elia M, Stratton RJ. Nutritional support and functional capacity in chronic obstructive pulmonary disease: a systematic review and meta-analysis. Respirology. 2013;18:616–29.
pubmed: 23432923
doi: 10.1111/resp.12070
Schols AM, Broekhuizen R, Weling-Scheepers CA, Wouters EF. Body composition and mortality in chronic obstructive pulmonary disease. Am J Clin Nutr. 2005;82:53–9.
pubmed: 16002800
doi: 10.1093/ajcn/82.1.53
Collins PF, Stratton RJ, Kurukulaaratchy RJ, Elia M. Influence of deprivation on health care use, health care costs, and mortality in COPD. Int J Chron Obstruct Pulmon Dis. 2018;13:1289–96.
pubmed: 29719384
pmcid: 5914553
doi: 10.2147/COPD.S157594
Collins PF, Elia M, Kurukulaaratchy RJ, Stratton RJ. The influence of deprivation on malnutrition risk in outpatients with chronic obstructive pulmonary disease (COPD). Clin Nutr. 2018;37:144–8.
pubmed: 27866758
doi: 10.1016/j.clnu.2016.11.005
Günay E, Kaymaz D, Selçuk NT, Ergün P, Sengül F, Demir N. Effect of nutritional status in individuals with chronic obstructive pulmonary disease undergoing pulmonary rehabilitation. Respirology. 2013;18:1217–22.
pubmed: 23714353
doi: 10.1111/resp.12133
Hoong JM, Ferguson M, Hukins C, Collins PF. Economic and operational burden associated with malnutrition in chronic obstructive pulmonary disease. Clin Nutr. 2017;36:1105–9.
pubmed: 27496063
doi: 10.1016/j.clnu.2016.07.008
Nguyen HT, Collins PF, Pavey TG, Nguyen NV, Pham TD, Gallegos DL. Nutritional status, dietary intake, and health-related quality of life in outpatients with COPD. Int J Chron Obstruct Pulmon Dis. 2019;14:215–26.
pubmed: 30666102
pmcid: 6336029
doi: 10.2147/COPD.S181322
Ferreira IM, Brooks D, Lacasse Y, Goldstein RS, White J. Nutritional supplementation for stable chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2012;12:CD000998.
Schols AM, Soeters PB, Mostert R, Pluymers RJ, Wouters EF. Physiologic effects of nutritional support and anabolic steroids in patients with chronic obstructive pulmonary disease. A placebo-controlled randomized trial. Am J Respir Crit Care Med. 1995;152:1268–74.
pubmed: 7551381
doi: 10.1164/ajrccm.152.4.7551381
Steiner MC, Barton RL, Singh SJ, Morgan MD. Nutritional enhancement of exercise performance in chronic obstructive pulmonary disease: a randomised controlled trial. Thorax. 2003;58:745–51.
pubmed: 12947128
pmcid: 1746806
doi: 10.1136/thorax.58.9.745
Vermeeren MA, Wouters EF, Geraerts-Keeris AJ, Schols AM. Nutritional support in patients with chronic obstructive pulmonary disease during hospitalization for an acute exacerbation; a randomized controlled feasibility trial. Clin Nutr. 2004;23:1184–92.
pubmed: 15380912
doi: 10.1016/j.clnu.2004.03.008
van Wetering CR, Hoogendoorn M, Broekhuizen R, Geraerts-Keeris GJ, De Munck DR, Rutten-van Mölken MP, et al. Efficacy and costs of nutritional rehabilitation in muscle-wasted patients with chronic obstructive pulmonary disease in a community-based setting: a prespecified subgroup analysis of the INTERCOM trial. J Am Med Dir Assoc. 2010;11:179–87.
pubmed: 20188315
doi: 10.1016/j.jamda.2009.12.083
Thornton Snider J, Jena AB, Linthicum MT, Hegazi RA, Partridge JS, LaVallee C, et al. Effect of hospital use of oral nutritional supplementation on length of stay, hospital cost, and 30-day readmissions among Medicare patients with COPD. Chest. 2015;147:1477–84.
doi: 10.1378/chest.14-1368
Wada H, Ikeda A, Maruyama K, Yamagishi K, Barnes PJ, Tanigawa T, et al. Low BMI and weight loss aggravate COPD mortality in men, findings from a large prospective cohort: the JACC study. Sci Rep. 2021;11:1531.
pubmed: 33452329
pmcid: 7810869
doi: 10.1038/s41598-020-79860-4
Pichard C, Kyle UG, Morabia A, Perrier A, Vermeulen B, Unger P. Nutritional assessment: lean body mass depletion at hospital admission is associated with an increased length of stay. Am J Clin Nutr. 2004;79:613–8.
pubmed: 15051605
doi: 10.1093/ajcn/79.4.613
Health Quality Ontario. Effect of early follow-up after hospital discharge on outcomes in patients with heart failure or chronic obstructive pulmonary disease: a systematic review. Ont Health Technol Assess Ser. 2017;17:1–37.
Braun E, Baidusi A, Alroy G, Azzam ZS. Telephone follow-up improves patients satisfaction following hospital discharge. Eur J Intern Med. 2009;20:221–5.
pubmed: 19327616
doi: 10.1016/j.ejim.2008.07.021
Odeh M, Scullin C, Fleming G, Scott MG, Horne R, McElnay JC. Ensuring continuity of patient care across the healthcare interface: telephone follow-up post-hospitalization. Br J Clin Pharmacol. 2019;85:616–25.
pubmed: 30675742
pmcid: 6379220
doi: 10.1111/bcp.13839
Stoller JK, Panos RJ, Krachman S, Doherty DE, Make B; Long-term Oxygen Treatment Trial Research Group. Oxygen therapy for patients with COPD: current evidence and the long-term oxygen treatment trial. Chest. 2010;138:179–87.
pubmed: 20605816
pmcid: 2897694
doi: 10.1378/chest.09-2555
Ringbaek TJ, Viskum K, Lange P. Does long-term oxygen therapy reduce hospitalisation in hypoxaemic chronic obstructive pulmonary disease? Eur Respir J. 2002;20:38–42.
pubmed: 12166578
doi: 10.1183/09031936.02.00284202
Cho KH, Kim YS, Nam CM, Kim TH, Kim SJ, Han K-T, et al. Home oxygen therapy reduces risk of hospitalisation in patients with chronic obstructive pulmonary disease: a population-based retrospective cohort study, 2005–2012. BMJ Open. 2015;5: e009065.
pubmed: 26621517
pmcid: 4679832
doi: 10.1136/bmjopen-2015-009065
Mannino DM, Kiriz VA. Changing the burden of COPD mortality. Int J Chron Obstruct Pulmon Dis. 2006;1:219–33.
pubmed: 18046859
pmcid: 2707151
Gauthier A, Bernard S, Bernard E, Simard S, Maltais F, Lacasse Y. Adherence to long-term oxygen therapy in patients with chronic obstructive pulmonary disease. Chron Respir Dis. 2019;16:1479972318767724.
pubmed: 29631423
doi: 10.1177/1479972318767724
Murphy PB, Rehal S, Arbane G, Bourke S, Calverley PM, Crook AM, et al. Effect of home noninvasive ventilation with oxygen therapy vs oxygen therapy alone on hospital readmission or death after an acute COPD exacerbation: a randomized clinical trial. JAMA. 2017;317:2177–86.
pubmed: 28528348
pmcid: 5710342
doi: 10.1001/jama.2017.4451
Casas A, Troosters T, Garcia-Aymerich J, Roca J, Hernández C, Alonso A, et al. Integrated care prevents hospitalisations for exacerbations in COPD patients. Eur Respir J. 2006;28:123–30.
pubmed: 16611656
doi: 10.1183/09031936.06.00063205
Al-Damluji MS, Dzara K, Hodshon B, Punnanithinont N, Krumholz HM, Chaudhry SI, et al. Association of discharge summary quality with readmission risk for patients hospitalized with heart failure exacerbation. Circ Cardiovasc Qual Outcomes. 2015;8:109–11.
pmcid: 4303529
doi: 10.1161/CIRCOUTCOMES.114.001476
Waeijen-Smit K, Jacobsen PA, Houben-Wilke S, Simons SO, Franssen FM, Spruit MA, et al. All-cause admissions following a first ever exacerbation-related hospitalisation in COPD. ERJ Open Res. 2023;9:00217–2022.
pubmed: 36605904
pmcid: 9808537
doi: 10.1183/23120541.00217-2022
Chetty U, McLean G, Morrison D, Agur K, Guthrie B, Mercer SW. Chronic obstructive pulmonary disease and comorbidities: a large cross-sectional study in primary care. Br J Gen Pract. 2017;67:e321–8.
pubmed: 28450344
doi: 10.3399/bjgp17X690605
Green ME, Natajaran N, O’Donnell DE, Williamson T, Kotecha J, Khan S, et al. Chronic obstructive pulmonary disease in primary care: an epidemiologic cohort study from the Canadian Primary Care Sentinel Surveillance Network. CMAJ Open. 2015;3:E15–22.
pubmed: 25844366
pmcid: 4382041
doi: 10.9778/cmajo.20140040
Cavaillès A, Brinchault-Rabin G, Dixmier A, Goupil F, Gut-Gobert C, Marchand-Adam S, et al. Comorbidities of COPD. Eur Respir Rev. 2013;22:454–75.
pubmed: 24293462
pmcid: 9639181
doi: 10.1183/09059180.00008612
Martinez-Garcia MA, Miravitlles M. Bronchiectasis in COPD patients: more than a comorbidity? Int J Chron Obstruct Pulmon Dis. 2017;12:1401–11.
pubmed: 28546748
pmcid: 5436792
doi: 10.2147/COPD.S132961
Sethi S. Infection as a comorbidity of COPD. Eur Respir J. 2010;35:1209–15.
pubmed: 20513910
doi: 10.1183/09031936.00081409
Iyer AS, Bhatt SP, Garner JJ, Wells JM, Trevor JL, Patel NM, et al. Depression is associated with readmission for acute exacerbation of chronic obstructive pulmonary disease. Ann Am Thorac Soc. 2016;13:197–203.
pubmed: 26599286
pmcid: 5461954
doi: 10.1513/AnnalsATS.201507-439OC
Gudmundsson G, Gislason T, Janson C, Lindberg E, Hallin R, Ulrik CS, et al. Risk factors for rehospitalisation in COPD: role of health status, anxiety and depression. Eur Respir J. 2005;26:414–9.
pubmed: 16135721
doi: 10.1183/09031936.05.00078504
Atwood CE, Bhutani M, Ospina MB, Rowe BH, Leigh R, Deuchar L, et al. Optimizing COPD acute care patient outcomes using a standardized transition bundle and care coordinator: a randomized clinical trial. Chest. 2022;162:321–30.
pubmed: 35405112
doi: 10.1016/j.chest.2022.03.047
Linden A, Butterworth S. A comprehensive hospital-based intervention to reduce readmissions for chronically ill patients: a randomized controlled trial. Am J Manag Care. 2014;20:783–92.
pubmed: 25365681
Abad-Corpa E, Royo-Morales T, Iniesta-Sánchez J, Carrillo-Alcaraz A, Rodríguez-Mondejar JJ, Saez-Soto AR, et al. Evaluation of the effectiveness of hospital discharge planning and follow-up in the primary care of patients with chronic obstructive pulmonary disease. J Clin Nurs. 2013;22:669–80.
pubmed: 22830974
Lainscak M, Kadivec S, Kosnik M, Benedik B, Bratkovic M, Jakhel T, et al. Discharge coordinator intervention prevents hospitalizations in patients with COPD: a randomized controlled trial. J Am Med Dir Assoc. 2013;14:450.
doi: 10.1016/j.jamda.2013.03.003
Yu S, Lu C, Qin L. A retrospective study of diaphragmatic breathing training combined with discharge care bundles in patients with chronic obstructive pulmonary disease. Evid Based Complement Alternat Med. 2022;2022:9649986.
pubmed: 36159577
pmcid: 9492362
doi: 10.1155/2022/9649986
Zafar MA, Loftus TM, Palmer JP, Phillips M, Ko J, Ward SR, et al. COPD care bundle in emergency department observation unit reduces emergency department revisits. Respir Care. 2020;65:1–10.
pubmed: 31882412
doi: 10.4187/respcare.07088
Cousse S, Gillibert A, Salaün M, Thiberville L, Cuvelier A, Patout M. Efficacy of a home discharge care bundle after acute exacerbation of COPD. Int J Chron Obstruct Pulmon Dis. 2019;14:289–96.
pubmed: 30774326
pmcid: 6349078
doi: 10.2147/COPD.S178147
Morton K, MacNeill S, Sanderson E, Dixon P, King A, Jenkins S, et al. Evaluation of “care bundles” for patients with chronic obstructive pulmonary disease (COPD): a multisite study in the UK. BMJ Open Respir Res. 2019;6:e000425.
pubmed: 31258918
pmcid: 6561386
doi: 10.1136/bmjresp-2019-000425
Hurst J, Amusan L, Akinyooye V, Andrews R, Adamson A, Stone P, et al. National Asthma and Chronic Obstructive Pulmonary Disease Audit Programme (NACAP). COPD clinical audit 2019/20 (people with COPD exacerbations discharged from acute hospitals in England, Scotland and Wales between October 2019 and February 2020). Data analysis and methodology report [Internet]. 2021 [cited 2023 May 13]. Available from: https://www.hqip.org.uk/resource/copd-clinical-audit-2019-20/
Lennox L, Green S, Howe C, Musgrave H, Bell D, Elkin S. Identifying the challenges and facilitators of implementing a COPD care bundle. BMJ Open Respir Res. 2014;1:e000035.
pubmed: 25478183
pmcid: 4213007
doi: 10.1136/bmjresp-2014-000035
Michas M, Deuchar L, Leigh R, Bhutani M, Rowe BH, Stickland MK, et al. Factors influencing the implementation and uptake of a discharge care bundle for patients with acute exacerbation of chronic obstructive pulmonary disease: a qualitative focus group study. Implement Sci Commun. 2020;1:3.
pubmed: 32924018
pmcid: 7477849
doi: 10.1186/s43058-020-00017-5
Shaw A, Morton K, King A, Chalder M, Calvert J, Jenkins S, et al. Using and implementing care bundles for patients with acute admission for COPD: qualitative study of healthcare professionals’ experience in four hospitals in England. BMJ Open Respir Res. 2020;7:e000515.
pubmed: 32213536
pmcid: 7173984
doi: 10.1136/bmjresp-2019-000515
Walters JA, Walters EH, Nelson M, Robinson A, Scott J, Turner P, et al. Factors associated with misdiagnosis of COPD in primary care. Prim Care Respir J. 2011;20:396–402.
pubmed: 21687918
pmcid: 6549875
doi: 10.4104/pcrj.2011.00039
Zwar NA, Marks GB, Hermiz O, Middleton S, Comino EJ, Hasan I, et al. Predictors of accuracy of diagnosis of chronic obstructive pulmonary disease in general practice. Med J Aust. 2011;195:168–71.
pubmed: 21843115
doi: 10.5694/j.1326-5377.2011.tb03271.x
Starren ES, Roberts NJ, Tahir M, O’Byrne L, Haffenden R, Patel IS, et al. A centralised respiratory diagnostic service for primary care: a 4-year audit. Prim Care Respir J. 2012;21:180–6.
pubmed: 22430040
pmcid: 6547918
doi: 10.4104/pcrj.2012.00013
Smethurst K, Gallacher J, Jopson L, Majiyagbe T, Johnson A, Copeman P, et al. Improved outcomes following the implementation of a decompensated cirrhosis discharge bundle. Frontline Gastroenterol. 2022;13:409–15.
pubmed: 36046493
doi: 10.1136/flgastro-2021-102021
Resar R, Griffin FA, Haraden C, Nolan TW. Using care bundles to improve health care quality. IHI innovation series white paper [Internet]. 2012 [cited 2023 May 13]. Available from: https://www.ihi.org/resources/Pages/IHIWhitePapers/UsingCareBundles.aspx?PostAuthRed=/resources/_layouts/download.aspx?SourceURL=/resources/Knowledge%20Center%20Assets/IHIWhitePapers
Cowie MR, Lopatin YM, Saldarriaga C, Fonseca C, Sim D, Magaña JA, et al. The Optimize Heart Failure Care Program: initial lessons from global implementation. Int J Cardiol. 2017;236:340–4.
pubmed: 28214078
doi: 10.1016/j.ijcard.2017.02.033
Gilhooly D, Green SA, McCann C, Black N, Moonesinghe SR. Barriers and facilitators to the successful development, implementation and evaluation of care bundles in acute care in hospital: a scoping review. Implement Sci. 2019;14:47.
pubmed: 31060625
pmcid: 6501296
doi: 10.1186/s13012-019-0894-2
Kourouche S, Buckley T, Van C, Munroe B, Curtis K. Designing strategies to implement a blunt chest injury care bundle using the behaviour change wheel: a multi-site mixed methods study. BMC Health Serv Res. 2019;19:461.
pubmed: 31286954
pmcid: 6615309
doi: 10.1186/s12913-019-4177-z
Hurst JR, Quint JK, Stone RA, Silove Y, Youde J, Roberts CM. National clinical audit for hospitalised exacerbations of COPD. ERJ Open Res. 2020;6:00208–2020.
pubmed: 32984418
pmcid: 7502696
doi: 10.1183/23120541.00208-2020
Jennings JH, Thavarajah K, Mendez MP, Eichenhorn M, Kvale P, Yessayan L. Predischarge bundle for patients with acute exacerbations of COPD to reduce readmissions and ED visits: a randomized controlled trial. Chest. 2015;147:1227–34.
Graham A. Impact of a combined admission and discharge COPD care bundle on hospital mortality and readmission rates. Thorax. 2012;67(Suppl. 2):A192-A193 (Abstract P290).
Laverty AA, Elkin SL, Watt HC, Millett C, Restrick LJ, Williams S, et al. Impact of a COPD discharge care bundle on readmissions following admission with acute exacerbation: interrupted time series analysis. PLOS ONE. 2015;10:e0116187.
pubmed: 25679218
pmcid: 4332682
doi: 10.1371/journal.pone.0116187
Halpin DM, Batten P, Chamberlain C. COPD discharge bundles: the Exeter experience 2011–12. Thorax. 2012;67(Suppl. 2):A193 (Abstract P291).
Matthews H, Tooley C, Nicholls C, Lindsey-Halls A. Care bundles reduce readmissions for COPD. Nurs Times. 2013;109:18–20.
pubmed: 23513935
Morton K, Sanderson E, Dixon P, King A, Jenkins S, MacNeill SJ, et al. Care bundles to reduce re-admissions for patients with chronic obstructive pulmonary disease: a mixed-methods study [Internet]. 2019 [cited 2023 May 13]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK541984/
Sewell L, Schreder S, Steiner M, Singh SJ. A strategy to implement a chronic obstructive pulmonary disease discharge care bundle on a large scale. Future Healthc J. 2017;4:198–201.
pubmed: 31098471
pmcid: 6502579
Seymour JM, Nedelcu D. The impact of a discharge care bundle on the 30-day readmission rate following hospitalisation for acute COPD exacerbation. Thorax. 2014;69(Suppl. 2):A141-A142 (Abstract P154).
Shorofsky M, Lebel M, Sedeno M, Zhi Li P, Bourbeau J. Discharge care bundle for patients with acute exacerbations of COPD: benefit more likely to be seen beyond 30 days. Int J Respir Pulm Med. 2015;2:024.
Stone PW, Adamson A, Hurst JR, Roberts CM, Quint JK. Does pay-for-performance improve patient outcomes in acute exacerbation of COPD admissions? Thorax. 2022;77:239–46.
pubmed: 34272333
doi: 10.1136/thoraxjnl-2021-216880
Yip NH, Brinson MD, Taylor BR, Regan BK, Lazar EJ, Thomashow BM. Implementation of a discharge bundle to lower COPD readmissions. Am J Respir Crit Care Med. 2012;185:A5146 (Abstract).