Quercetin inhibits Toxoplasma gondii tachyzoite proliferation and acts synergically with azithromycin.

Animals Toxoplasma / metabolism Azithromycin / pharmacology Quercetin / pharmacology Parasites Anti-Infective Agents / pharmacology Cell Proliferation
Azithromycin Combination Growth Inhibition Quercetin Synergizes Toxoplasma gondii

Journal

Parasites & vectors
ISSN: 1756-3305
Titre abrégé: Parasit Vectors
Pays: England
ID NLM: 101462774

Informations de publication

Date de publication:
03 Aug 2023
Historique:
received: 09 02 2023
accepted: 26 06 2023
medline: 7 8 2023
pubmed: 4 8 2023
entrez: 3 8 2023
Statut: epublish

Résumé

Quercetin (QUE) is a natural polyphenol known to have numerous pharmacological properties against infectious and non-infectious diseases. Azithromycin (AZ) is an antibiotic that belongs to the azalide class of antimicrobials and an antiparasitic that is known to be effective in combination with clindamycin against pyrimethamine/sulfadiazine-resistant Toxoplasma gondii tachyzoites in clinical settings. Both compounds are known to target protein synthesis and have anti-inflammatory properties. However, little is known about QUE and AZ synergistic interaction against T. gondii growth. Here, we report for the first time the effects of the combination of QUE and AZ on T. gondii growth. The 50% inhibitory concentration (IC

Identifiants

DOI: 10.1186/s13071-023-05849-3 PMID: 37537675 PMC: PMC10401810
pubmed: 37537675
doi: 10.1186/s13071-023-05849-3
pii: 10.1186/s13071-023-05849-3
pmc: PMC10401810
doi:

Substances chimiques

Azithromycin 83905-01-5
Quercetin 9IKM0I5T1E
Anti-Infective Agents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

261

Informations de copyright

© 2023. BioMed Central Ltd., part of Springer Nature.

Références

Front Microbiol. 2019 Sep 18;10:2152
pubmed: 31620108
Emerg Infect Dis. 2019 Apr;25(4):841-843
pubmed: 30882331
J Cell Biochem. 2008 Dec 15;105(6):1386-98
pubmed: 18980244
Apoptosis. 2008 Jul;13(7):867-82
pubmed: 18506627
ACS Omega. 2020 May 14;5(20):11849-11872
pubmed: 32478277
J Transl Med. 2014 May 19;12:132
pubmed: 24885122
Free Radic Biol Med. 2011 Jul 15;51(2):454-63
pubmed: 21571063
Front Cell Infect Microbiol. 2021 Mar 19;11:618994
pubmed: 33816332
J Gynecol Obstet Hum Reprod. 2018 Mar;47(3):133-140
pubmed: 29229361
Sci Rep. 2023 May 29;13(1):8667
pubmed: 37248277
Nutrition. 2011 Jul-Aug;27(7-8):847-52
pubmed: 21371861
Int J Parasitol Drugs Drug Resist. 2019 Apr;9:27-34
pubmed: 30599391
Chem Biol Drug Des. 2018 Jan;91(1):194-201
pubmed: 28696589
PLoS One. 2014 Mar 24;9(3):e90203
pubmed: 24662942
J Antimicrob Chemother. 1996 Jun;37 Suppl C:1-8
pubmed: 8818841
Pathog Glob Health. 2013 Jun;107(4):162-9
pubmed: 23816507
J Parasit Dis. 2020 Mar;44(1):221-229
pubmed: 32174728
Sci Rep. 2016 Mar 15;6:22997
pubmed: 26976749
Parasitol Int. 2018 Apr;67(2):107-111
pubmed: 29081387
Front Cell Infect Microbiol. 2017 Dec 12;7:512
pubmed: 29312892
Antimicrob Agents Chemother. 1989 Oct;33(10):1753-9
pubmed: 2531568
Sci Rep. 2021 Jan 13;11(1):1035
pubmed: 33441899
Polym Bull (Berl). 2023;80(1):241-262
pubmed: 35125574
Chem Phys Lipids. 2006 Oct;144(1):108-16
pubmed: 17007828
Antimicrob Agents Chemother. 2018 Jan 25;62(2):
pubmed: 29133550
BMC Pharmacol Toxicol. 2016 Aug 04;17(1):39
pubmed: 27491399
N Engl J Med. 1994 Jun 30;330(26):1858-63
pubmed: 7818637
Front Microbiol. 2018 Oct 29;9:2587
pubmed: 30420849
Front Cell Dev Biol. 2021 Jun 11;9:684393
pubmed: 34179016
Int J Parasitol. 2009 Oct;39(12):1385-94
pubmed: 19433092
PLoS One. 2011 Feb 08;6(2):e14666
pubmed: 21346801
Drugs R D. 2017 Dec;17(4):523-544
pubmed: 28879584
Antimicrob Agents Chemother. 2013 Feb;57(2):907-13
pubmed: 23208707
Free Radic Biol Med. 2017 Jul;108:760-769
pubmed: 28476502
J Ethnopharmacol. 2012 Sep 28;143(2):383-96
pubmed: 22820241
J Pharmacol Sci. 2011;115(4):466-70
pubmed: 21436601
Molecules. 2020 Mar 30;25(7):
pubmed: 32235463
Phytomedicine. 2014 Oct 15;21(12):1689-94
pubmed: 25442278
Front Cell Infect Microbiol. 2022 May 11;12:852889
pubmed: 35646733
Food Chem. 2012 Jul 15;133(2):445-50
pubmed: 25683418
N Engl J Med. 1992 Dec 3;327(23):1643-8
pubmed: 1359410
Acta Trop. 2012 Feb;121(2):55-70
pubmed: 22085916
BMC Biol. 2015 Jul 18;13:52
pubmed: 26187647
Infection. 2018 Jun;46(3):303-315
pubmed: 29330674
Antimicrob Agents Chemother. 1993 Aug;37(8):1701-3
pubmed: 8215287
J Antimicrob Chemother. 1996 Jul;38(1):75-80
pubmed: 8858459
PLoS One. 2020 Nov 6;15(11):e0241304
pubmed: 33156838
J Nat Prod. 2018 Aug 24;81(8):1910-1913
pubmed: 30095915

Auteurs

Daniel A Abugri (DA)

Department of Biological Sciences, College of Science, Technology, Engineering and Mathematics, Alabama State University, Montgomery, AL, 36104, USA. dabugri@alasu.edu.
Microbiology PhD Program, Department of Biological Sciences, College of Science, Technology, Engineering and Mathematics, Alabama State University, Montgomery, AL, 36104, USA. dabugri@alasu.edu.
Laboratory of Ethnomedicine, Parasitology and Drug Discovery, College of Science, Technology, Engineering and Mathematics, Alabama State University, Montgomery, AL, 36104, USA. dabugri@alasu.edu.

Sandani V T Wijerathne (SVT)

Department of Biological Sciences, College of Science, Technology, Engineering and Mathematics, Alabama State University, Montgomery, AL, 36104, USA.
Microbiology PhD Program, Department of Biological Sciences, College of Science, Technology, Engineering and Mathematics, Alabama State University, Montgomery, AL, 36104, USA.

Homa Nath Sharma (HN)

Department of Biological Sciences, College of Science, Technology, Engineering and Mathematics, Alabama State University, Montgomery, AL, 36104, USA.
Microbiology PhD Program, Department of Biological Sciences, College of Science, Technology, Engineering and Mathematics, Alabama State University, Montgomery, AL, 36104, USA.
Laboratory of Ethnomedicine, Parasitology and Drug Discovery, College of Science, Technology, Engineering and Mathematics, Alabama State University, Montgomery, AL, 36104, USA.

Joseph A Ayariga (JA)

Department of Biological Sciences, College of Science, Technology, Engineering and Mathematics, Alabama State University, Montgomery, AL, 36104, USA.

Audrey Napier (A)

Department of Biological Sciences, College of Science, Technology, Engineering and Mathematics, Alabama State University, Montgomery, AL, 36104, USA.

Boakai K Robertson (BK)

Department of Biological Sciences, College of Science, Technology, Engineering and Mathematics, Alabama State University, Montgomery, AL, 36104, USA.
Microbiology PhD Program, Department of Biological Sciences, College of Science, Technology, Engineering and Mathematics, Alabama State University, Montgomery, AL, 36104, USA.

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Classifications MeSH

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