Synthesis and characterization of amino sulfonic acid functionalized graphene oxide as a potential carrier for quercetin.
Nanocomposite
cytocompatibility
drug delivery
nanocarrier
Journal
Turkish journal of chemistry
ISSN: 1300-0527
Titre abrégé: Turk J Chem
Pays: Turkey
ID NLM: 101259104
Informations de publication
Date de publication:
2022
2022
Historique:
received:
24
07
2021
revised:
05
08
2022
accepted:
23
02
2022
medline:
23
2
2022
pubmed:
23
2
2022
entrez:
4
8
2023
Statut:
epublish
Résumé
In this investigation, a new nanocomposite as a nanocarrier based on functionalized graphene oxide was synthesized by reaction of tetraethylenepentamine and chlorosulfonic acid with functional groups on the surface of GO. The synthesized nanocomposite was characterized by FT-IR, XRD TGA, FE-SEM, EDAX, TEM, and AFM analysis. To explore the potential of nanocomposites in drug delivery, the loading and releases of quercetin as an anticancer drug were investigated. The result displayed that more than 90% of the drug was loaded on the nanocarrier and the release of the drug is depending on the pH of the environment such that the releases of the drug in Gastric and intestinal conditions were up to 50% and 30%, respectively. The analysis of toxicity effect on the normal and cancer cells indicated that the nanocarrier with the drug has potential for cancer cells therapy without cytotoxic effect on normal cells in IC
Identifiants
pubmed: 37538784
doi: 10.55730/1300-0527.3409
pii: turkjchem-46-4-987
pmc: PMC10395694
doi:
Types de publication
Journal Article
Langues
eng
Pagination
987-998Informations de copyright
© TÜBİTAK.
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