The prevalence of treatment-emergent central sleep apnea with mandibular advancement device therapy.


Journal

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
ISSN: 1550-9397
Titre abrégé: J Clin Sleep Med
Pays: United States
ID NLM: 101231977

Informations de publication

Date de publication:
01 12 2023
Historique:
pmc-release: 01 12 2024
medline: 4 12 2023
pubmed: 4 8 2023
entrez: 4 8 2023
Statut: ppublish

Résumé

Treatment-emergent central sleep apnea (TECSA) describes the appearance or persistence of central sleep apnea while undergoing treatment for obstructive sleep apnea. TECSA is well studied in continuous positive airway pressure therapy with an estimated prevalence of 8%. Based on a few case reports, mandibular advancement devices (MAD) may also provoke TECSA. This study aims to gain insight into the prevalence of TECSA with MAD therapy. This retrospective study includes a total of 129 patients with moderate to severe obstructive sleep apnea who were treated with a custom-made titratable MAD. Baseline and follow-up sleep studies were compared to identify patients with TECSA. Since different diagnostic criteria to define TECSA are used in literature, prevalence was calculated according to three definitions (TECSA-1, -2, and -3). Demographics, MAD treatment variables, and findings of the diagnostic polysomnography were compared between TECSA and non-TECSA patients to identify possible predictors. Depending on the definition used, TECSA was found in 3.1%-7.8% of patients undergoing MAD therapy. TECSA patients had a higher apnea index (9.2 vs 2.0 events/h, These findings demonstrate that TECSA also occurs in patients starting MAD treatment. Patients with TECSA had a higher apnea index, central apnea-hypopnea index, and oxygen desaturation index at baseline compared to non-TECSA patients. Hellemans S, Van de Perck E, Braem MJ, Verbraecken J, Dieltjens M, Vanderveken OM. The prevalence of treatment-emergent central sleep apnea with mandibular advancement device therapy.

Identifiants

pubmed: 37539639
pii: jcsm.10742
doi: 10.5664/jcsm.10742
pmc: PMC10692941
doi:

Substances chimiques

Oxygen S88TT14065

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2035-2041

Informations de copyright

© 2023 American Academy of Sleep Medicine.

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Auteurs

Simon Hellemans (S)

Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.
ENT, Head and Neck Surgery, Antwerp University Hospital, Edegem, Belgium.

Eli Van de Perck (E)

Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.
ENT, Head and Neck Surgery, Antwerp University Hospital, Edegem, Belgium.

Marc J Braem (MJ)

Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.
Special Dentistry Care, Antwerp University Hospital, Edegem, Belgium.

Johan Verbraecken (J)

Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.
Multidisciplinary Sleep Disorders Centre, Antwerp University Hospital, Edegem, Belgium.
Department of Pulmonology, Antwerp University Hospital, Edegem, Belgium.

Marijke Dieltjens (M)

Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.
ENT, Head and Neck Surgery, Antwerp University Hospital, Edegem, Belgium.
Special Dentistry Care, Antwerp University Hospital, Edegem, Belgium.

Olivier M Vanderveken (OM)

Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.
ENT, Head and Neck Surgery, Antwerp University Hospital, Edegem, Belgium.
Multidisciplinary Sleep Disorders Centre, Antwerp University Hospital, Edegem, Belgium.

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