METTL14‑mediated RNA methylation in digestive system tumors.
digestive system tumors
m6A
methyltransferase
methyltransferase‑like 14
Journal
International journal of molecular medicine
ISSN: 1791-244X
Titre abrégé: Int J Mol Med
Pays: Greece
ID NLM: 9810955
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
03
03
2023
accepted:
06
07
2023
medline:
7
8
2023
pubmed:
4
8
2023
entrez:
4
8
2023
Statut:
ppublish
Résumé
N6‑methyladenosine (m6A) RNA methylation is one of the most common post‑transcriptional modification mechanism in eukaryotes. m6A is involved in almost all stages of the mRNA life cycle, specifically regulating its stability, splicing, export and translation. Methyltransferase‑like 14 (METTL14) is a particularly important m6A methylation 'writer' that can recognize RNA substrates. METTL14 has been documented to improve the activity and catalytic efficiency of METTL3. However, as individual proteins they can also regulate different biological processes. Malignancies in the digestive system are some of the most common malignancies found in humans, which are typically associated with poor prognoses with limited clinical solutions. METTL14‑mediated methylation has been implicated in both the potentiation and inhibition of digestive system tumor growth, cell invasion and metastasis, in addition to drug resistance. In the present review, the research progress and regulatory mechanisms of METTL14‑mediated methylation in digestive system malignancies were summarized. In addition, future research directions and the potential for its clinical application were examined.
Identifiants
pubmed: 37539726
doi: 10.3892/ijmm.2023.5289
pii: 86
pmc: PMC10555478
doi:
pii:
Substances chimiques
RNA
63231-63-0
METTL3 protein, human
EC 2.1.1.62
Methyltransferases
EC 2.1.1.-
METTL14 protein, human
EC 2.1.1.-
Types de publication
Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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