Parasite manipulation of host phenotypes inferred from transcriptional analyses in a trematode-amphipod system.
Orchestia grillus
amphipod
differential expression
ecological genomics
host-parasite co-evolution
infection response
parasite manipulation
population genetics
trematode
Journal
Molecular ecology
ISSN: 1365-294X
Titre abrégé: Mol Ecol
Pays: England
ID NLM: 9214478
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
revised:
21
07
2023
received:
03
04
2023
accepted:
25
07
2023
pmc-release:
01
09
2024
medline:
6
9
2023
pubmed:
4
8
2023
entrez:
4
8
2023
Statut:
ppublish
Résumé
Manipulation of host phenotypes by parasites is hypothesized to be an adaptive strategy enhancing parasite transmission across hosts and generations. Characterizing the molecular mechanisms of manipulation is important to advance our understanding of host-parasite coevolution. The trematode (Levinseniella byrdi) is known to alter the colour and behaviour of its amphipod host (Orchestia grillus) presumably increasing predation of amphipods which enhances trematode transmission through its life cycle. We sampled 24 infected and 24 uninfected amphipods from a salt marsh in Massachusetts to perform differential gene expression analysis. In addition, we constructed novel genomic tools for O. grillus including a de novo genome and transcriptome. We discovered that trematode infection results in upregulation of amphipod transcripts associated with pigmentation and detection of external stimuli, and downregulation of multiple amphipod transcripts implicated in invertebrate immune responses, such as vacuolar ATPase genes. We hypothesize that suppression of immune genes and the altered expression of genes associated with coloration and behaviour may allow the trematode to persist in the amphipod and engage in further biochemical manipulation that promotes transmission. The genomic tools and transcriptomic analyses reported provide new opportunities to discover how parasites alter diverse pathways underlying host phenotypic changes in natural populations.
Identifiants
pubmed: 37540037
doi: 10.1111/mec.17093
pmc: PMC10529729
mid: NIHMS1921171
doi:
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
5028-5041Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM109035
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM067862
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM139607
Pays : United States
Informations de copyright
© 2023 The Authors. Molecular Ecology published by John Wiley & Sons Ltd.
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