Genotypic Analysis of

Humans Collagen Type IV / genetics Diabetes Mellitus, Type 2 / complications Diabetic Nephropathies / genetics Fibrosis Gene Frequency Genetic Predisposition to Disease / genetics Genotype
COL4A1 gene polymorphism diabetes mellitus diabetic nephropathy genotypic analysis north Indian population rs605143

Journal

DNA and cell biology
ISSN: 1557-7430
Titre abrégé: DNA Cell Biol
Pays: United States
ID NLM: 9004522

Informations de publication

Date de publication:
Sep 2023
Historique:
medline: 11 9 2023
pubmed: 4 8 2023
entrez: 4 8 2023
Statut: ppublish

Résumé

Diabetic nephropathy (DN) is specified by microalbuminuria, glomerular lesions, and renal fibrosis leading to end-stage renal disease. The pathophysiology of DN is multifactorial as a result of gene-environment interaction. Clinical studies suggested that gene mutations affect various pathways involved in DN, including extracellular matrix (ECM). During chronic hyperglycemia, collagen type-4-mediated ECM overproduction occurs, leading to renal fibrosis and DN development. In this study,

Identifiants

DOI: 10.1089/dna.2023.0125 PMID: 37540089
pubmed: 37540089
doi: 10.1089/dna.2023.0125
doi:

Substances chimiques

COL4A1 protein, human 0
Collagen Type IV 0

Types de publication

Comparative Study Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

541-547

Auteurs

Neha Shukla (N)

Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Shivani Kumari (S)

Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Poornima Verma (P)

Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Atar Singh Kushwah (AS)

Department of Biological Science, Center for Nano Biotechnology Research, Alabama State University, Montgomery, Alabama, USA.
Molecular and Human Genetics Laboratory, Department of Zoology, University of Lucknow, Lucknow, Uttar Pradesh, India.

Monisha Banarjee (M)

Molecular and Human Genetics Laboratory, Department of Zoology, University of Lucknow, Lucknow, Uttar Pradesh, India.

S N Sankhwar (SN)

Department of Urology, King George's Medical University, Lucknow, India.

Aneesh Srivastava (A)

Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

M S Ansari (MS)

Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Naveen Kumar Gautam (NK)

Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
ORCID: 0000-0002-8644-4344

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genotypic Analysis of
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Protéines de la matrice extracellulaire › Collagène › Collagènes non fibrillaires › Collagène de type IV › Genotypic Analysis of
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › Genotypic Analysis of
questionsmedicales.fr › Maladies endocriniennes › Diabète › Complications du diabète › Néphropathies diabétiques › Genotypic Analysis of
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fibrose › Genotypic Analysis of
questionsmedicales.fr › Phénomènes génétiques › Fréquence d'allèle › Genotypic Analysis of
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Genotypic Analysis of
questionsmedicales.fr › Phénomènes génétiques › Génotype › Genotypic Analysis of