Cytomegalovirus anterior uveitis and occlusive retinal vasculitis without retinitis in a patient on immunomodulatory therapy.
Cytomegalovirus virus
Endotheliitis
Retinal vasculitis
Retinitis
Uveitis
Journal
Journal of ophthalmic inflammation and infection
ISSN: 1869-5760
Titre abrégé: J Ophthalmic Inflamm Infect
Pays: Germany
ID NLM: 101553216
Informations de publication
Date de publication:
04 Aug 2023
04 Aug 2023
Historique:
received:
22
06
2023
accepted:
11
07
2023
medline:
4
8
2023
pubmed:
4
8
2023
entrez:
4
8
2023
Statut:
epublish
Résumé
To describe unusual clinical features and therapeutic management of a case of cytomegalovirus (CMV) ocular disease in a patient on immunomodulatory therapy. Moorfields Eye Hospital NHS Foundation Trust, London, UK. Medical history, clinical findings, investigation results, and multimodal imaging were retrospectively collected. A 61-year-old, South-East Asian man, developed CMV-related endotheliitis and occlusive retinal vasculitis, diagnosed by wide-angle fluorescein angiography. No retinitis was present on the fundus examination. Suspicion of CMV etiology was based on anterior segment findings, especially the presence of coin-shaped endothelial lesions. The diagnosis was confirmed by aqueous polymerase chain reaction (PCR) analysis which was positive for CMV DNA. The combined use of topical and systemic valganciclovir resulted in significant improvement of the picture. CMV can manifest in the eye as occlusive retinal vasculitis without the presence of typical retinitis.
Identifiants
pubmed: 37540447
doi: 10.1186/s12348-023-00356-z
pii: 10.1186/s12348-023-00356-z
pmc: PMC10403449
doi:
Types de publication
Journal Article
Langues
eng
Pagination
34Informations de copyright
© 2023. Springer-Verlag GmbH Germany, part of Springer Nature.
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