Organotin(IV)-Decorated Graphene Quantum Dots as Dual Platform for Molecular Imaging and Treatment of Triple Negative Breast Cancer.
biomedical molecular imaging
graphene quantum dots
metallodrugs
organotin
theranostic
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
26 Oct 2023
26 Oct 2023
Historique:
received:
08
06
2023
medline:
30
10
2023
pubmed:
4
8
2023
entrez:
4
8
2023
Statut:
ppublish
Résumé
The pharmacological activity of organotin(IV) complexes in cancer therapy is well recognized but their large applicability is hampered by their poor water solubility. Hence, carbon dots, in particular nitrogen-doped graphene quantum dots (NGQDs), may be a promising alternative for the efficient delivery of organotin(IV) compounds as they have a substantial aqueous solubility, a good chemical stability, and non-toxicity as well as a bright photoluminescence that make them ideal for theranostic applications against cancer. Two different multifunctional nanosystems have been synthesized and fully characterized based on two fragments of organotin-based cytotoxic compounds and 4-formylbenzoic acid (FBA), covalently grafted onto the NGQDs surface. Subsequently, an in vitro determination of the therapeutic and theranostic potential of the achieved multifunctional systems was carried out. The results showed a high cytotoxic potential of the NGQDs-FBA-Sn materials against breast cancer cell line (MDA-MB-231) and a lower effect on a non-cancer cell line (kidney cells, HEK293T). Besides, thanks to their optical properties, the dots enabled their fluorescence molecular imaging in the cytoplasmatic region of the cells pointing towards a successful cellular uptake and a release of the metallodrug inside cancer cells (NGQDs-FBA-Sn).
Identifiants
pubmed: 37540499
doi: 10.1002/chem.202301845
doi:
Substances chimiques
Graphite
7782-42-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202301845Subventions
Organisme : Ministerio de Universidades
ID : UP2021-001
Organisme : Ministerstvo Školství, Mládeže a Tělovýchovy
ID : CZ.02.2.69/0.0/0.0/20_079/0017045
Organisme : Ministerstvo Školství, Mládeže a Tělovýchovy
ID : LM2018110; LM2018121
Organisme : Instituto de Salud Carlos III
ID : DTS20/00109
Organisme : Ministerio de Ciencia e Innovación
ID : PID2022-136417NB-I00
Organisme : Ministerio de Ciencia e Innovación
ID : CEX2020-001041-S
Organisme : Ministerio de Ciencia e Innovación
ID : RED2022-134091-T
Informations de copyright
© 2023 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.
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