Adseverin, an actin-binding protein, modulates hypertrophic chondrocyte differentiation and osteoarthritis progression.


Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
04 08 2023
Historique:
medline: 7 8 2023
pubmed: 4 8 2023
entrez: 4 8 2023
Statut: ppublish

Résumé

In osteoarthritis (OA), a disease characterized by progressive articular cartilage degradation and calcification, the articular chondrocyte phenotype changes and this correlates with actin cytoskeleton alterations suggesting that it regulates gene expression essential for proper phenotype. This study reports that OA is associated with the loss of adseverin, an actin capping and severing protein. Adseverin deletion (Adseverin

Identifiants

pubmed: 37540756
doi: 10.1126/sciadv.adf1130
pmc: PMC10403223
doi:

Substances chimiques

Microfilament Proteins 0
scinderin 0
Hedgehog Proteins 0
Actins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadf1130

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Auteurs

Byron Chan (B)

Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada.
Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

Michael Glogauer (M)

Faculty of Dentistry, University of Toronto, Toronto, ON, Canada.

Yongqiang Wang (Y)

Faculty of Dentistry, University of Toronto, Toronto, ON, Canada.

Jeffrey Wrana (J)

Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada.

Kin Chan (K)

Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada.

Frank Beier (F)

Department of Physiology and Pharmacology, Western University, London, ON, Canada.

Supinder Bali (S)

Department of Physiology and Pharmacology, Western University, London, ON, Canada.

Boris Hinz (B)

Faculty of Dentistry, University of Toronto, Toronto, ON, Canada.
Laboratory of Tissue Repair and Regeneration, Keenan Research Centre for Biomedical Science of the St. Michael's Hospital, Toronto, ON, Canada.

Justin Parreno (J)

Department of Biological Sciences, University of Delaware, Newark, DE, USA.

Sajjad Ashraf (S)

Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada.

Rita Kandel (R)

Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada.
Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

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Classifications MeSH