Conformation Dependent Architectures of Assembled Antimicrobial Peptides with Enhanced Antimicrobial Ability.
antimicrobial peptides
antimicrobial resistance
conformation
nanostructures
self-assembly
Journal
Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613
Informations de publication
Date de publication:
11 2023
11 2023
Historique:
revised:
19
07
2023
received:
26
05
2023
medline:
23
11
2023
pubmed:
4
8
2023
entrez:
4
8
2023
Statut:
ppublish
Résumé
Antimicrobial peptides (AMPs) are a developing class of natural and synthetic oligopeptides with host defense mechanisms against a broad spectrum of microorganisms. With in-depth research on the structural conformations of AMPs, synthesis or modification of peptides has shown great potential in effectively obtaining new therapeutic agents with improved physicochemical and biological properties. Notably, AMPs with self-assembled properties have gradually become a hot research topic for various biomedical applications. Compared to monomeric peptides, these peptides can exist in diverse forms (e.g., nanoparticles, nanorods, and nanofibers) and possess several advantages, such as high stability, good biocompatibility, and potent biological functions, after forming aggregates under specific conditions. In particular, the stability and antibacterial property of these AMPs can be modulated by rationally regulating the peptide sequences to promote self-assembly, leading to the reconstruction of molecular structure and spatial orientation while introducing some peptide fragments into the scaffolds. In this work, four self-assembled AMPs are developed, and the relationship between their chemical structures and antibacterial activity is explored extensively through different experiments. Importantly, the evaluation of antibacterial performance in both in vitro and in vivo studies has provided a general guide for using self-assembled AMPs in subsequent treatments for combating bacterial infections.
Identifiants
pubmed: 37540835
doi: 10.1002/adhm.202301688
doi:
Substances chimiques
Antimicrobial Peptides
0
Antimicrobial Cationic Peptides
0
Anti-Bacterial Agents
0
Oligopeptides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2301688Subventions
Organisme : National Key Research and Development Program of China
ID : 2021YFA1201000
Organisme : National Key Research and Development Program of China
ID : 2018YFE0117800
Organisme : Beijing Municipal Education Commission
ID : KM202310025022
Organisme : National Natural Science Foundation of China
ID : 31971312
Organisme : National Natural Science Foundation of China
ID : 32171389
Organisme : National Natural Science Foundation of China
ID : 32030060
Organisme : National Natural Science Foundation of China
ID : E3041101
Organisme : HKU Seed Fund for Basic Research
ID : 104006533
Organisme : HKU Seed Fund for Basic Research
ID : 104005845
Organisme : Health and Medical Research Fund from Hong Kong Food and Health Bureau
ID : 20190682
Organisme : Capital Medical University Young Scientist Program
ID : YSP202011
Organisme : Beijing Municipal Colleges and Universities High Level Talents Introduction and Cultivate Project-Beijing Great Wall Scholar Program
ID : CIT&TCD 20180332
Informations de copyright
© 2023 Wiley-VCH GmbH.
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