Enhanced glycolysis-mediated energy production in alveolar stem cells is required for alveolar regeneration.

Mice Animals AMP-Activated Protein Kinases / metabolism Alveolar Epithelial Cells / metabolism Lung Stem Cells Cell Differentiation Glycolysis
aging alveolar stem cells energy metabolism fibrosis resolution lung regeneration mechanical

Journal

Cell stem cell
ISSN: 1875-9777
Titre abrégé: Cell Stem Cell
Pays: United States
ID NLM: 101311472

Informations de publication

Date de publication:
03 08 2023
Historique:
received: 27 12 2022
revised: 07 06 2023
accepted: 12 07 2023
medline: 7 8 2023
pubmed: 5 8 2023
entrez: 4 8 2023
Statut: ppublish

Résumé

Impaired differentiation of alveolar stem cells has been identified in a variety of acute and chronic lung diseases. In this study, we investigate the mechanisms that modulate alveolar regeneration and understand how aging impacts this process. We have discovered that the process of alveolar type II (AT2) cells differentiating into AT1 cells is an energetically costly process. During alveolar regeneration, activated AMPK-PFKFB2 signaling upregulates glycolysis, which is essential to support the intracellular energy expenditure that is required for cytoskeletal remodeling during AT2 cell differentiation. AT2 cells in aged lungs exhibit reduced AMPK-PFKFB2 signaling and ATP production, resulting in impaired alveolar regeneration. Activating AMPK-PFKFB2 signaling in aged AT2 cells can rescue defective alveolar regeneration in aged mice. Thus, beyond demonstrating that cellular energy metabolism orchestrates with stem cell differentiation during alveolar regeneration, our study suggests that modulating AMPK-PFKFB2 signaling promotes alveolar repair in aged lungs.

Identifiants

DOI: 10.1016/j.stem.2023.07.007 PMID: 37541209
pubmed: 37541209
pii: S1934-5909(23)00253-9
doi: 10.1016/j.stem.2023.07.007
pii:
doi:

Substances chimiques

AMP-Activated Protein Kinases EC 2.7.11.31

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1028-1042.e7

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Zheng Wang (Z)

National Institute of Biological Sciences, Beijing, China; Graduate School of Peking Union Medical College, Beijing, China.

Dongdong Wei (D)

National Institute of Biological Sciences, Beijing, China; Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program, Peking University, Beijing, China.

Ennan Bin (E)

National Institute of Biological Sciences, Beijing, China.

Jiao Li (J)

National Institute of Biological Sciences, Beijing, China.

Kewu Jiang (K)

National Institute of Biological Sciences, Beijing, China.

Tingting Lv (T)

Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.

Xiaoxu Mao (X)

National Institute of Biological Sciences, Beijing, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China.

Fengchao Wang (F)

National Institute of Biological Sciences, Beijing, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China.

Huaping Dai (H)

Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.

Nan Tang (N)

National Institute of Biological Sciences, Beijing, China; Graduate School of Peking Union Medical College, Beijing, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China. Electronic address: tangnan@nibs.ac.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Enhanced glycolysis-mediated energy production...
questionsmedicales.fr › Eucaryotes › Animaux › Enhanced glycolysis-mediated energy production...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › AMP-Activated Protein Kinases › Enhanced glycolysis-mediated energy production...
questionsmedicales.fr › Cellules › Cellules épithéliales › Pneumocytes › Enhanced glycolysis-mediated energy production...
questionsmedicales.fr › Appareil respiratoire › Poumon › Enhanced glycolysis-mediated energy production...
questionsmedicales.fr › Cellules › Cellules souches › Enhanced glycolysis-mediated energy production...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Enhanced glycolysis-mediated energy production...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Glycolyse › Enhanced glycolysis-mediated energy production...