Anti-inflammatory potency of novel ecto-5'-nucleotidase/CD73 inhibitors in astrocyte culture model of neuroinflammation.

Humans Astrocytes / metabolism Neuroinflammatory Diseases 5'-Nucleotidase / metabolism Anti-Inflammatory Agents / pharmacology
Astrocytes Cell migration Cytosine-based nucleoside 5'-α,β-methylene diphosphates Ecto-5′-nucleotidase/CD73 Shedding

Journal

European journal of pharmacology
ISSN: 1879-0712
Titre abrégé: Eur J Pharmacol
Pays: Netherlands
ID NLM: 1254354

Informations de publication

Date de publication:
05 Oct 2023
Historique:
received: 16 05 2023
revised: 03 07 2023
accepted: 31 07 2023
pmc-release: 05 10 2024
medline: 31 8 2023
pubmed: 5 8 2023
entrez: 4 8 2023
Statut: ppublish

Résumé

Three novel cytosine-derived α,β-methylene diphosphonates designated MRS4598, MRS4552, and MRS4602 were tested in the range of 1 × 10

Identifiants

DOI: 10.1016/j.ejphar.2023.175943 PMID: 37541364 PMC: PMC10527948
pubmed: 37541364
pii: S0014-2999(23)00455-7
doi: 10.1016/j.ejphar.2023.175943
pmc: PMC10527948
mid: NIHMS1922953
pii:
doi:

Substances chimiques

5'-Nucleotidase EC 3.1.3.5
Anti-Inflammatory Agents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

175943

Subventions

Organisme : Intramural NIH HHS
ID : ZIA DK031117
Pays : United States

Informations de copyright

Copyright © 2023 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors' individual contributions are listed in a separate section of the manuscript. The authors declare no professional, financial, personal, or other conflicts of interest. All authors have approved the manuscript and submission to European Journal of Pharmacology and agree with the order of authors in the manuscript.

Références

J Med Chem. 2010 Mar 11;53(5):2076-86
pubmed: 20146483
Front Neurosci. 2018 Aug 03;12:520
pubmed: 30123104
J Immunol. 2013 Oct 15;191(8):4165-73
pubmed: 24043904
Adv Healthc Mater. 2013 Sep;2(9):1188-97
pubmed: 23713066
Nat Rev Mol Cell Biol. 2006 Apr;7(4):265-75
pubmed: 16607289
MAbs. 2016;8(3):454-67
pubmed: 26854859
J Neurosci Res. 2017 Apr;95(4):1053-1066
pubmed: 27714837
Neurochem Int. 2012 Oct;61(5):681-8
pubmed: 22750273
Cell Tissue Res. 2008 Nov;334(2):199-217
pubmed: 18843508
FEBS Lett. 1988 Oct 10;238(2):419-23
pubmed: 2844608
J Neurosci. 2004 Mar 17;24(11):2837-45
pubmed: 15028778
Expert Opin Ther Pat. 2021 Oct;31(10):867-876
pubmed: 33909515
J Mol Neurosci. 2015 Nov;57(3):452-62
pubmed: 26080748
Front Neurosci. 2018 Feb 06;12:43
pubmed: 29467608
Bioorg Med Chem Lett. 2020 May 1;30(9):127067
pubmed: 32165041
J Med Chem. 2015 Aug 13;58(15):6248-63
pubmed: 26147331
J Med Chem. 2012 Jul 26;55(14):6576-81
pubmed: 22731815
Cell Mol Neurobiol. 2007 Sep;27(6):791-804
pubmed: 17712627
Cell Death Differ. 2010 Jul;17(7):1071-82
pubmed: 19763139
Biochem Pharmacol. 2015 Jan 15;93(2):171-81
pubmed: 25449596
Front Neurosci. 2021 Jul 16;15:702581
pubmed: 34335174
Cancer Immunol Immunother. 2023 Jul;72(7):2443-2458
pubmed: 37016126
Cancer Cell. 2013 Jun 10;23(6):839-52
pubmed: 23684459
Biochim Biophys Acta. 2008 Jan;1782(1):35-40
pubmed: 18062933
J Med Chem. 2019 Apr 11;62(7):3677-3695
pubmed: 30895781
Front Pharmacol. 2018 Mar 27;9:266
pubmed: 29636685
Trends Immunol. 2004 Jan;25(1):33-9
pubmed: 14698282
Front Aging Neurosci. 2010 Oct 25;2:142
pubmed: 21152343
J Biol Chem. 1999 Aug 6;274(32):22705-12
pubmed: 10428853
Cancer Cell. 2019 Dec 9;36(6):582-596
pubmed: 31821783
J Neurochem. 2016 Dec;139(6):1019-1055
pubmed: 27365148
PLoS Comput Biol. 2018 Jan 29;14(1):e1005943
pubmed: 29377887
J Neurochem. 1997 Sep;69(3):1145-50
pubmed: 9282937
Brain Res. 2007 Sep 7;1168:1-10
pubmed: 17706943
Gene. 1993 Nov 15;133(2):171-7
pubmed: 8224905
Purinergic Signal. 2016 Dec;12(4):719-734
pubmed: 27650530
Expert Opin Ther Pat. 2018 Feb;28(2):167-171
pubmed: 29166791
Mol Neurobiol. 2023 Mar;60(3):1659-1674
pubmed: 36547848
J Mol Neurosci. 2015 Apr;55(4):898-911
pubmed: 25326791
J Med Chem. 2021 Jan 14;64(1):845-860
pubmed: 33399453
Biochim Biophys Acta. 2007 Sep;1770(9):1352-9
pubmed: 17643826
J Med Biochem. 2015 Apr;34(2):215-222
pubmed: 28356834
Brain Res. 2000 Dec 29;887(2):250-8
pubmed: 11134613
Nature. 2016 Apr 14;532(7598):195-200
pubmed: 27027288
Biochim Biophys Acta. 2011 May;1808(5):1380-99
pubmed: 21145878
Brain. 2019 Mar 1;142(3):700-718
pubmed: 30689733
Front Immunol. 2019 Jul 26;10:1729
pubmed: 31404305
Pharmacol Res. 2020 Dec;162:105253
pubmed: 33080321
Biochem J. 1998 May 15;332 ( Pt 1):101-9
pubmed: 9576857
Biochim Biophys Acta. 2008 May;1783(5):673-94
pubmed: 18302942
Biochem Pharmacol. 1973 Dec 1;22(23):3099-108
pubmed: 4202581
Front Pharmacol. 2012 Jun 26;3:120
pubmed: 22740833
Pharmacol Rev. 2011 Mar;63(1):1-34
pubmed: 21303899
Glia. 2011 Jun;59(6):869-81
pubmed: 21446038
Front Pharmacol. 2018 Mar 01;9:153
pubmed: 29545748
Nat Commun. 2011;2:334
pubmed: 21629267
Nat Neurosci. 2008 Nov;11(11):1294-301
pubmed: 18931666
Glia. 2012 Apr;60(4):615-29
pubmed: 22262260
J Neurochem. 1993 Jan;60(1):219-27
pubmed: 8417143
J Med Chem. 2022 Feb 10;65(3):2409-2433
pubmed: 35080883
Biochem J. 1992 Jul 15;285 ( Pt 2):345-65
pubmed: 1637327
Cell Stem Cell. 2013 Apr 4;12(4):426-39
pubmed: 23561443
J Alzheimers Dis. 2012;31(3):555-67
pubmed: 22647260

Auteurs

Katarina Mihajlovic (K)

Laboratory for Neurobiology, Department of General Physiology and Biophysics, Faculty of Biology University of Belgrade, Serbia.

Marija Adzic Bukvic (MA)

Laboratory for Neurobiology, Department of General Physiology and Biophysics, Faculty of Biology University of Belgrade, Serbia.

Milorad Dragic (M)

Laboratory for Neurobiology, Department of General Physiology and Biophysics, Faculty of Biology University of Belgrade, Serbia.

Mirko Scortichini (M)

Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.

Kenneth A Jacobson (KA)

Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.

Nadezda Nedeljkovic (N)

Laboratory for Neurobiology, Department of General Physiology and Biophysics, Faculty of Biology University of Belgrade, Serbia. Electronic address: nnedel@bio.bg.ac.rs.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Anti-inflammatory potency of novel...
questionsmedicales.fr › Cellules › Névroglie › Astrocytes › Anti-inflammatory potency of novel...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Maladies neuro-inflammatoires › Anti-inflammatory potency of novel...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Phosphoric monoester hydrolases › Nucleotidases › 5'-Nucleotidase › Anti-inflammatory potency of novel...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Anti-inflammatory potency of novel...