Role of cytokines and reactive oxygen species in brain aging.
Cytokines
Depression
Immunosenescence
Inflammaging
Neurodegeneration
Neurotransmitters
Reactive oxygen species
Journal
Mechanisms of ageing and development
ISSN: 1872-6216
Titre abrégé: Mech Ageing Dev
Pays: Ireland
ID NLM: 0347227
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
21
11
2022
revised:
24
07
2023
accepted:
01
08
2023
pmc-release:
01
09
2024
medline:
7
9
2023
pubmed:
5
8
2023
entrez:
4
8
2023
Statut:
ppublish
Résumé
Aging is a complex process that produces profound effects on the brain. Although a number of external factors can promote the initiation and progression of brain aging, peripheral and central changes in the immune cells with time, also play an important role. Immunosenescence, which is an age-associated decline in immune function and Inflammaging, a low-grade inflammatory state in the aging brain contribute to an elevation in cytokine and reactive oxygen species production. In this review, we focus on the pro-inflammatory state that is established in the brain as a consequence of these two phenomena and the resulting detrimental changes in brain structure, function and repair that lead to a decline in central and neuroendocrine function.
Identifiants
pubmed: 37541628
pii: S0047-6374(23)00081-7
doi: 10.1016/j.mad.2023.111855
pmc: PMC10528856
mid: NIHMS1927897
pii:
doi:
Substances chimiques
Cytokines
0
Reactive Oxygen Species
0
Types de publication
Review
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
111855Subventions
Organisme : NIA NIH HHS
ID : R41 AG069539
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest Authors declare that they have no conflicts of interest to disclose.
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