Increased body weight in mice with fragile X messenger ribonucleoprotein 1 (Fmr1) gene mutation is associated with hypothalamic dysfunction.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
04 08 2023
04 08 2023
Historique:
received:
15
03
2023
accepted:
28
07
2023
medline:
7
8
2023
pubmed:
5
8
2023
entrez:
4
8
2023
Statut:
epublish
Résumé
Mutations in the Fragile X Messenger Ribonucleoprotein 1 (FMR1) gene are linked to Fragile X Syndrome, the most common monogenic cause of intellectual disability and autism. People affected with mutations in FMR1 have higher incidence of obesity, but the mechanisms are largely unknown. In the current study, we determined that male Fmr1 knockout mice (KO, Fmr1
Identifiants
pubmed: 37542065
doi: 10.1038/s41598-023-39643-z
pii: 10.1038/s41598-023-39643-z
pmc: PMC10403586
doi:
Substances chimiques
Fmr1 protein, mouse
0
Fragile X Mental Retardation Protein
139135-51-6
messenger ribonucleoprotein
0
Pro-Opiomelanocortin
66796-54-1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
12666Subventions
Organisme : NICHD NIH HHS
ID : R01 HD091167
Pays : United States
Informations de copyright
© 2023. Springer Nature Limited.
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