Circulating short chain fatty acids and fatigue in patients with head and neck cancer: A longitudinal prospective study.
Fatigue
Gene expression
Inflammation
Radiotherapy, chemotherapy, head and neck cancer
Short chain fatty acids
Journal
Brain, behavior, and immunity
ISSN: 1090-2139
Titre abrégé: Brain Behav Immun
Pays: Netherlands
ID NLM: 8800478
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
12
04
2023
revised:
13
07
2023
accepted:
30
07
2023
pmc-release:
01
10
2024
medline:
4
9
2023
pubmed:
6
8
2023
entrez:
5
8
2023
Statut:
ppublish
Résumé
Fatigue among patients with head and neck cancer (HNC) has been associated with higher inflammation. Short-chain fatty acids (SCFAs) have been shown to have anti-inflammatory and immunoregulatory effects. Therefore, this study aimed to examine the association between SCFAs and fatigue among patients with HNC undergoing treatment with radiotherapy with or without concurrent chemotherapy. Plasma SCFAs and the Multidimensional Fatigue Inventory-20 were collected prior to and one month after the completion of treatment in 59 HNC patients. The genome-wide gene expression profile was obtained from blood leukocytes prior to treatment. Lower butyrate concentrations were significantly associated with higher fatigue (p = 0.013) independent of time of assessment, controlling for covariates. A similar relationship was observed for iso/valerate (p = 0.025). Comparison of gene expression in individuals with the top and bottom 33% of butyrate or iso/valerate concentrations prior to radiotherapy revealed 1,088 and 881 significantly differentially expressed genes, respectively (raw p < 0.05). The top 10 Gene Ontology terms from the enrichment analyses revealed the involvement of pathways related to cytokines and lipid and fatty acid biosynthesis. These findings suggest that SCFAs may regulate inflammatory and immunometabolic responses and, thereby, reduce inflammatory-related symptoms, such as fatigue.
Identifiants
pubmed: 37543249
pii: S0889-1591(23)00218-0
doi: 10.1016/j.bbi.2023.07.025
pmc: PMC10528227
mid: NIHMS1926737
pii:
doi:
Substances chimiques
Fatty Acids, Volatile
0
Butyrates
0
Valerates
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
432-443Subventions
Organisme : NINR NIH HHS
ID : R01 NR020188
Pays : United States
Organisme : NINR NIH HHS
ID : R01 NR015783
Pays : United States
Organisme : NINR NIH HHS
ID : R00 NR014587
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA138292
Pays : United States
Organisme : NINR NIH HHS
ID : K99 NR014587
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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