Prevalence and risk factors of diabetes mellitus and hypertension in North East Tunisia calling for efficient and effective actions.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
05 08 2023
05 08 2023
Historique:
received:
31
08
2022
accepted:
21
07
2023
medline:
7
8
2023
pubmed:
6
8
2023
entrez:
5
8
2023
Statut:
epublish
Résumé
Diabetes and hypertension are a serious public health problem worldwide. In the last decades, prevalence of these two metabolic diseases has dramatically increased in the Middle East and North Africa region, especially in Tunisia. This study aimed to determine the prevalence of type 2 diabetes (T2D) and High Blood Pressure (HBP) in Zaghouan, a North-East region of Tunisia. To this end, an exploratory study with stratified random sampling of 420 participants has been carried out. Various data were collected. Blood samples and urine were drawn for biochemical assay. Then, all data were analyzed using the statistical R software. Results showed an alarming situation with an inter-regional difference in prevalence of obesity (50.0%, CI 95.0%), HBP (39.0%, CI 95.0%) and T2D (32.0%, CI 95.0%). This study allowed the discovery of 24, 17 and 2 new cases of T2D, HBP and T2D&HBP respectively. The association of some socio-economic factors and biochemical parameters with these chronic diseases has been highlighted. To conclude, the health situation in the governorate of Zaghouan requires urgent interventions to better manage the growing epidemic of non-communicable diseases (NCD) in the region. This study demonstrated the importance of engaging health policy makers in road mapping and implementing national NCD prevention programs.
Identifiants
pubmed: 37543635
doi: 10.1038/s41598-023-39197-0
pii: 10.1038/s41598-023-39197-0
pmc: PMC10404238
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
12706Informations de copyright
© 2023. Springer Nature Limited.
Références
Avogaro, A. & Fadini, G. P. Microvascular complications in diabetes: A growing concern for cardiologists. Int. J. Cardiol. 291, 29–35 (2019).
pubmed: 30833106
Zanchetti, A. Epidemiological, pathophysiological and therapeutic aspects of hypertension. J. Hypertens. 35, 1917–1918 (2017).
pubmed: 28787306
Cho, N., Kirigia, J., Ogurstova, K. & Reja, A. IDF Diabetes Atlas (2021).
Tabrizi, J. S., Sadeghi-Bazargani, H., Farahbakhsh, M., Nikniaz, L. & Nikniaz, Z. Prevalence and associated factors of prehypertension and hypertension in Iranian population: The lifestyle promotion project (LPP). PLoS ONE 11, 1–15 (2016).
Nejjari, C. et al. Epidemiological trial of hypertension in North Africa (ETHNA): An international multicentre study in Algeria, Morocco and Tunisia. J. Hypertens. 31, 49–62 (2013).
pubmed: 23221932
Dzudie, A. et al. Roadmap to achieve 25% hypertension control in Africa by 2025. Cardiovasc. J. Afr. 28, 262–273 (2017).
pubmed: 28906541
Prevalence of Diabetes in the Tunisian Population: Results of the ATERA-Survey. https://www.sciencedirect.com/science/article/abs/pii/S1878648022005341 .
Boujnah, R., Nazek, L., Maalej, M., EL Achhab, Y. & Nejjari, C. Hypertension in Tunisian adults attending primary care physicians (ETHNA-Tunisia). Indian Heart J. 70, 544–547 (2018).
pubmed: 30170651
Saidi, O. et al. Forecasting Tunisian type 2 diabetes prevalence to 2027: Validation of a simple model Biostatistics and methods. BMC Public Health 15, 1–8 (2015).
Ben Romdhane, H. et al. Prevalence of diabetes in Northern African countries: The case of Tunisia. BMC Public Health 14, 1–13 (2014).
Ng, R., Sutradhar, R., Yao, Z., Wodchis, W. P. & Rosella, L. C. Smoking, drinking, diet and physical activity—Modifiable lifestyle risk factors and their associations with age to first chronic disease. Int. J. Epidemiol. 49, 113–130 (2020).
pubmed: 31329872
Taherdoost, H. Sampling methods in research methodology: How to choose a sampling technique for research. SSRN Electron. J. 5, 18–27 (2018).
Ministère de la santé. Santé Tunisie en chiffres 2018 (2018).
Cochran, W. Sampling Techniques 3rd edn, Vol. 3 (Wiley, 1977).
American Diabetes Association. 2. Classification and diagnosis of diabetes: Standards of medical care in diabetes-2021. Diabetes Care 44, S15–S33 (2021).
James, P. A. et al. 2014 Evidence-based guideline for the management of high blood pressure in adults: Report from the panel members appointed to the Eighth Joint National Committee (JNC 8). J. Am. Med. Assoc. 311, 507–520 (2014).
Nuttall, F. Q. Body mass index: Obesity, BMI, and health: A critical review. Nutr. Today 50, 117–128 (2015).
pubmed: 27340299
pmcid: 4890841
Jacobsen, B. K. & Aars, N. A. Changes in waist circumference and the prevalence of abdominal obesity during 1994–2008—Cross-sectional and longitudinal results from two surveys: The Tromsø study. BMC Obes. 3, 1–8 (2016).
R Core Team. R A Language and Environment for Statistical Computing. https://scirp.org/reference/referencespapers.aspx?referenceid=3064798 (R Foundation for Statistical Computing, Scientific Research Publishing, 2020).
Gharbi, M., Akrout, M. & Zouari, B. Prevalence and risk factors of non-insulin-dependent diabetes mellitus in the rural and urban population of Tunisia. Rev. Epidemiol. Sante Publ. 50, 349 (2002).
Zaoui, S., Biémont, C. & Meguenni, K. Epidemiology of diabetes in urban and rural regions of Tlemcen (Western Algeria). Cah. Sante 17, 15–21 (2007).
Bachir Cherif, A. et al. Prevalence of diabetes and dyslipidemia in hypertensive patients in the area of Blida (Algeria). Ann. Cardiol. Angeiol. 67, 198–203 (2018).
Hamida, F. et al. Prévalence de l’hypertension artérielle dans l’oasis d’El-Menia, Algérie, et profil métabolique de la population. Ann. Cardiol. Angeiol. (Paris) 62, 172–178 (2013).
pubmed: 23711897
Kim, J. H. et al. Diabetic factors associated with gastrointestinal symptoms in patients with type 2 diabetes. World J Gastroenterol. 16(14), 1782–1787. https://doi.org/10.3748/wjg.v16.i14.1782 (2010).
pubmed: 20380013
pmcid: 2852829
Yazdanpanah, L. et al. Prevalence, awareness and risk factors of diabetes in Ahvaz (South West of Iran). Diabetes Metab. Syndr. Clin. Res. Rev. 10, S114–S118 (2016).
MDiCI. Élaboration d’un plan de développement stratégique du gouvernorat de Zaghouan a l’Horizon 2030 Troisième phase : Rapport de Synthèse et moyen de mise en oeuvre Commissariat Général au Développement Régional Groupement Troisième phase: Rapport de synthèse 1–183 (2017).
Hamed Ferjani, A., Guellala, R., Amiri, A., Merzougui, A. & Inoubli, M. H. Structuration profonde dans la région de Bir M’Chergua (Nord-Est de la Tunisie). Implications hydrogéologiques. Estud. Geol. 74, 075 (2018).
Sondermann, M. et al. Diabetes mellitus and hypertension—A case of sugar and salt? Int. J. Mol. Sci. 21, 1–7 (2020).
Yatabe, M. S. et al. Salt sensitivity is associated with insulin resistance, sympathetic overactivity, and decreased suppression of circulating renin activity in lean patients with essential hypertension. Am. J. Clin. Nutr. 92, 77–82 (2010).
pubmed: 20444953
Mutyambizi, C., Booysen, F., Stokes, A., Pavlova, M. & Groot, W. Lifestyle and socio-economic inequalities in diabetes prevalence in South Africa: A decomposition analysis. PLoS ONE 14, 1–21 (2019).
Diabetes, W. J. Contents, Vol. 9358 (2021).
Prevalence of Obesity and Overweight in Tunisia on 2001. https://pubmed.ncbi.nlm.nih.gov/19472725/ .
Tunisia. 2016 (2016).
Mokhtar, N. et al. Symposium: Obesity in Developing Countries: Biological and Ecological Factors Diet Culture and Obesity in Northern Africa 1 887–892 (2018).
Lemamsha, H., Randhawa, G. & Papadopoulos, C. Prevalence of overweight and obesity among Libyan men and women. Biomed. Res. Int. 2019, 1–16 (2019).
Al-Sumaih, I., Johnston, B., Donnelly, M. & O’Neill, C. The relationship between obesity, diabetes, hypertension and vitamin D deficiency among Saudi Arabians aged 15 and over: Results from the Saudi health interview survey. BMC Endocr. Disord. 20, 1–9 (2020).
Masilela, C., Pearce, B., Ongole, J. J., Adeniyi, O. V. & Benjeddou, M. Cross-sectional study of prevalence and determinants of uncontrolled hypertension among South African adult residents of Mkhondo municipality. BMC Public Health 20, 1–11 (2020).
Drexel, H. et al. Is atherosclerosis in diabetes and impaired fasting glucose driven by elevated LDL cholesterol or by decreased HDL cholesterol? Diabetes Care 28, 101–107 (2005).
pubmed: 15616241
Jemaa, R., Razgallah, R., Ben Ghorbel, I., Rais, L. & Kallel, A. Prevalence of cardiovascular risk factors in the Tunisian population: The ATERA-survey. Arch. Cardiovasc. Dis. Suppl. 12, 159 (2020).
Tunisian Health Examination (2019).
Liu, S. et al. Application of three statistical models for predicting the risk of diabetes. BMC Endocr. Disord. 19, 1–10 (2019).
Zheng, J. S. et al. The association between circulating 25-hydroxyvitamin D metabolites and type 2 diabetes in European populations: A meta-analysis and Mendelian randomisation analysis. PLoS Med. 17, 1–21 (2020).
Grundmann, S. M. et al. Vitamin d receptor deficiency does not affect blood pressure and heart function. Front. Physiol. 10, 1–11 (2019).
Lips, P. et al. Vitamin D and type 2 diabetes. J. Steroid Biochem. Mol. Biol. 173, 280–285 (2017).
pubmed: 27932304
Nwosu, B. U. & Maranda, L. The effects of vitamin D supplementation on hepatic dysfunction, vitamin D status, and glycemic control in children and adolescents with vitamin D deficiency and either type 1 or type 2 diabetes mellitus. PLoS ONE 9, 1–9 (2014).
Von Hurst, P. R., Stonehouse, W. & Coad, J. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient-a randomised, placebo-controlled trial. Br. J. Nutr. 103, 549–555 (2010).
Wuerzner, G., Burnier, M. & Waeber, B. Hypertension et vitamine D: Retour sur la scène. Rev. Med. Suisse 7, 121–124 (2011).
pubmed: 21400943
Fakhfakh, R. et al. Vitamin D status and CYP27B1-1260 promoter polymorphism in Tunisian patients with systemic lupus erythematosus. Mol. Genet. Genom. Med. 9, 1–9 (2021).
Leiva, M., Cristi-Montero, S., Ramírez-Campillo, D., Aguilar-Farías, C.-M. & Leiva, M. El sedentarismo se asocia a un incremento de factores de riesgo cardiovascular y metabólicos independiente de los niveles de actividad física 458–467 (2014).
Mc Namara, K., Alzubaidi, H. & Jackson, J. K. Cardiovascular disease as a leading cause of death: How are pharmacists getting involved? Integr. Pharm. Res. Pract. 8, 1–11 (2019).
pubmed: 30788283
pmcid: 6366352