Application of Ultrasound Shear Wave Elastography Combined With BRAFV600E Mutation for the Diagnosis of Papillary Thyroid Carcinoma.
Journal
Ultrasound quarterly
ISSN: 1536-0253
Titre abrégé: Ultrasound Q
Pays: United States
ID NLM: 8809459
Informations de publication
Date de publication:
01 Dec 2023
01 Dec 2023
Historique:
medline:
29
11
2023
pubmed:
6
8
2023
entrez:
6
8
2023
Statut:
epublish
Résumé
This prospective study aimed to investigate the combination of shear wave elastography (SWE) and BRAFV600E mutation testing for the diagnosis of papillary thyroid carcinoma (PTC). One hundred thyroid nodules with an American College of Radiology thyroid imaging reporting and data system classification of 4 or 5 were subjected to SWE measurement, BRAFV600E genotyping, fine-needle aspiration, and surgery. Nonparametric statistical tests were used to compare the differences in the elastic parameters and BRAF genotypes between benign and malignant thyroid nodules of PTC, and receiver operating characteristic curve analysis was conducted to compare the diagnostic efficacy. In addition, the correlations between elastic parameters and BRAFV600E mutation in PTC were analyzed using binary logistic regression. The SWE, BRAFV600E, and their combination exhibited sensitivities of 72.9%, 81.3%, and 85.4%, respectively, and specificities of 66.7%, 90.3%, and 86.5%, respectively, in the diagnosis of PTC ( P < 0.05). The SWE, BRAFV600E, and their combination exhibited sensitivities of 50.0%, 24.1% and 56.3%, respectively, and specificities of 89.7%, 87.5% and 82.8%, respectively, in the diagnosis of central cervical lymph node metastasis ( P < 0.05). The combined use of SWE and BRAFV600E detection had the largest area under the curve, indicating that this combination is more effective in diagnosing PTC and lymph node metastasis in the central region than either method alone. Furthermore, Emax was positively associated with the BRAFV600E genotype. In conclusion, the combination of SWE and BRAFV600E genotype detection can improve the diagnostic efficacy for PTC. Emax can predict the BRAFV600E mutation status.
Identifiants
pubmed: 37543733
doi: 10.1097/RUQ.0000000000000647
pii: 00013644-202312000-00004
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
199-205Informations de copyright
Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.
Références
Lim H, Devesa SS, Sosa JA, et al. Trends in thyroid cancer incidence and mortality in the United States, 1974-2013. JAMA . 2017;317(13):1338–1348.
Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin . 2021;71(3):209–249.
Marotta V, Russo G, Gambardella C, et al. Human exposure to bisphenol AF and diethylhexylphthalate increases susceptibility to develop differentiated thyroid cancer in patients with thyroid nodules. Chemosphere . 2019;218:885–894.
Marotta V, Malandrino P, Russo M, et al. Fathoming the link between anthropogenic chemical contamination and thyroid cancer. Crit Rev Oncol Hematol . 2020;150:102950.
Dudea SM, Botar-Jid C. Ultrasound elastography in thyroid disease. Med Ultrason . 2015;17(1):74–96.
Wang F, Chang C, Chen M, et al. Does lesion size affect the value of shear wave elastography for differentiating between benign and malignant thyroid nodules? J Ultrasound Med . 2017;37(3):601–609.
Azizi G, Keller JM, Mayo ML, et al. Shear wave elastography and Afirma™ gene expression classifier in thyroid nodules with indeterminate cytology: a comparison study. Endocrine . 2018;59(3):573–584.
Park AY, Son EJ, Han K, et al. Shear wave elastography of thyroid nodules for the prediction of malignancy in a large scale study. Eur J Radiol . 2015;84(3):407–412.
Li X, Hou XJ, Du LY, et al. Virtual touch tissue imaging and quantification (VTIQ) combined with the American College of Radiology Thyroid Imaging Reporting and Data System (ACR TI-RADS) for malignancy risk stratification of thyroid nodules. Clin Hemorheol Microcirc . 2019;72(3):279–291.
Ye W, Hannigan B, Zalles S, et al. Centrifuged supernatants from FNA provide a liquid biopsy option for clinical next-generation sequencing of thyroid nodules. Cancer Cytopathol . 2019;127(3):146–160.
Khatami F, Larijani B, Heshmat R, et al. Hypermethylated RASSF1 and SLC5A8 promoters alongside BRAF V600E mutation as biomarkers for papillary thyroid carcinoma. J Cell Physiol . 2020;235(10):6954–6968.
Seo JY, Kim EK, Baek JH, et al. Can ultrasound be as a surrogate marker for diagnosing a papillary thyroid cancer? Comparison with BRAF mutation analysis. Yonsei Med J . 2014;55(4):871–878.
Zhu X, Peng X, Zhu L, et al. Evaluation of the diagnostic performance of contrast-enhanced ultrasound combined with BRAF V600E gene detection in nodules of unclear significance by thyroid fine-needle aspiration. Gland Surg . 2021;10(1):328–335.
Chen L, Chen L, Liu J, et al. The association among quantitative contrast-enhanced ultrasonography features, thyroid imaging reporting and data system and BRAF V600E mutation status in patients with papillary thyroid microcarcinoma. Ultrasound Q . 2019;35(3):228–232.
Rho M, Kim EK, Moon HJ, et al. Clinical parameter for deciding the BRAFV600E mutation test in atypia of undetermined significance/follicular lesion of undetermined significance thyroid nodules: US features according to TIRADS. Ultrasound Q . 2017;33(4):284–288.
Ferraioli G, Barr RG, Farrokh A, et al. How to perform shear wave elastography. Part I. Med Ultrason . 2022;24(1):95–106.
Cibas ES, Ali SZ. The Bethesda system for reporting thyroid cytopathology. Thyroid . 2009;19(11):1159–1165.
Yoo MH, Kim HJ, Choi IH, et al. Shear wave elasticity by tracing total nodule showed high reproducibility and concordance with fibrosis in thyroid cancer. BMC Cancer . 2020;20(1):118.
Swan KZ, Nielsen VE, Bibby BM, et al. Is the reproducibility of shear wave elastography of thyroid nodules high enough for clinical use? A methodological study. Clin Endocrinol (Oxf) . 2017;86(4):606–613.
Yi L, Qiong W, Yan W, et al. Correlation between ultrasound elastography and histologic characteristics of papillary thyroid carcinoma. Sci Rep . 2017;7:45042.
Kim HJ, Choi IH, Jin SY, et al. Efficacy of shear-wave elastography for detecting postoperative cervical lymph node metastasis in papillary thyroid carcinoma. Int J Endocrinol . 2018;2018:9382649.
Jiang W, Wei HY, Zhang HY, et al. Value of contrast-enhanced ultrasound combined with elastography in evaluating cervical lymph node metastasis in papillary thyroid carcinoma. World J Clin Cases . 2019;7(1):49–57.
Kılıç A, Çolakoğlu Er H. Virtual touch tissue imaging quantification shear wave elastography for determining benign versus malignant cervical lymph nodes: a comparison with conventional ultrasound. Diagn Interv Radiol . 2019;25(2):114–121.
Bhatia KS, Tong CS, Cho CC, et al. Shear wave elastography of thyroid nodules in routine clinical practice: preliminary observations and utility for detecting malignancy. Eur Radiol . 2012;22(11):2397–2406.
Dobruch-Sobczak K, Zalewska EB, Gumińska A, et al. Diagnostic performance of shear wave elastography parameters alone and in combination with conventional B-mode ultrasound parameters for the characterization of thyroid nodules: a prospective, dual-center study. Ultrasound Med Biol . 2016;42(12):2803–2811.
Rominger MB, Kälin P, Mastalerz M, et al. Influencing factors of 2D shear wave elastography of the muscle—an ex vivo animal study. Ultrasound Int Open . 2018;4(2):E54–E60.
Brezak R, Hippe D, Thiel J, et al. Variability in stiffness assessment in a thyroid nodule using shear wave imaging. Ultrasound Q . 2015;31(4):243–249.
Dong Y, Mao M, Zhan W, et al. Size and ultrasound features affecting results of ultrasound-guided fine-needle aspiration of thyroid nodules. J Ultrasound Med . 2018;37(6):1367–1377.
Haugen BR. 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: what is new and what has changed? Cancer . 2017;123(3):372–381.
Chen J, Li XL, Zhang YF, et al. Ultrasound validation of predictive model for central cervical lymph node metastasis in papillary thyroid cancer on BRAF . Future Oncol . 2020;16(22):1607–1618.
Mostoufi-Moab S, Labourier E, Sullivan L, et al. Molecular testing for oncogenic gene alterations in pediatric thyroid lesions. Thyroid . 2018;28(1):60–67.
Tam AA, Kaya C, Üçler R, et al. Correlation of normal thyroid ultrasonography with thyroid tests. Quant Imaging Med Surg . 2015;5(4):569–574.
Ren H, Shen Y, Hu D, et al. Co-existence of BRAF V600E and TERT promoter mutations in papillary thyroid carcinoma is associated with tumor aggressiveness, but not with lymph node metastasis. Cancer Manag Res . 2018;10:1005–1013.
Krasner JR, Alyouha N, Pusztaszeri M, et al. Molecular mutations as a possible factor for determining extent of thyroid surgery. J Otolaryngol Head Neck Surg . 2019;48(1):51.
Lee JH, Lee ES, Kim YS. Clinicopathologic significance of BRAF V600E mutation in papillary carcinomas of the thyroid: a meta-analysis. Cancer . 2007;110(1):38–46.
Liu X, Yan K, Lin X, et al. The association between BRAF (V600E) mutation and pathological features in PTC. Eur Arch Otorhinolaryngol . 2014;271(11):3041–3052.
Hahn SY, Kim TH, Ki CS, et al. Ultrasound and clinicopathological features of papillary thyroid carcinomas with BRAF and TERT promoter mutations. Oncotarget . 2017;8(65):108946–108957.
Chen J, Li XL, Zhao CK, et al. Conventional ultrasound, immunohistochemical factors and BRAF(V600E) mutation in predicting central cervical lymph node metastasis of papillary thyroid carcinoma. Ultrasound Med Biol . 2018;44(11):2296–2306.
Shao J, Shen Y, Lü J, et al. Ultrasound scoring in combination with ultrasound elastography for differentiating benign and malignant thyroid nodules. Clin Endocrinol (Oxf) . 2015;83(2):254–260.