The PARN, TOE1, and USB1 RNA deadenylases and their roles in non-coding RNA regulation.

Humans Dyskeratosis Congenita / physiopathology Exoribonucleases / genetics Neutropenia / physiopathology RNA Stability / genetics RNA, Untranslated / genetics Loss of Function Mutation
PARN TOE1 USB1 deadenylases non-coding RNA regulation

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
09 2023
Historique:
received: 13 05 2023
revised: 28 07 2023
accepted: 29 07 2023
medline: 23 10 2023
pubmed: 7 8 2023
entrez: 6 8 2023
Statut: ppublish

Résumé

The levels of non-coding RNAs (ncRNAs) are regulated by transcription, RNA processing, and RNA degradation pathways. One mechanism for the degradation of ncRNAs involves the addition of oligo(A) tails by non-canonical poly(A) polymerases, which then recruit processive sequence-independent 3' to 5' exonucleases for RNA degradation. This pathway of decay is also regulated by three 3' to 5' exoribonucleases, USB1, PARN, and TOE1, which remove oligo(A) tails and thereby can protect ncRNAs from decay in a manner analogous to the deubiquitination of proteins. Loss-of-function mutations in these genes lead to premature degradation of some ncRNAs and lead to specific human diseases such as Poikiloderma with Neutropenia (PN) for USB1, Dyskeratosis Congenita (DC) for PARN and Pontocerebellar Hypoplasia type 7 (PCH7) for TOE1. Herein, we review the biochemical properties of USB1, PARN, and TOE1, how they modulate ncRNA levels, and their roles in human diseases.

Identifiants

DOI: 10.1016/j.jbc.2023.105139 PMID: 37544646 PMC: PMC10493513
pubmed: 37544646
pii: S0021-9258(23)02167-1
doi: 10.1016/j.jbc.2023.105139
pmc: PMC10493513
pii:
doi:

Substances chimiques

Exoribonucleases EC 3.1.-
RNA, Untranslated 0
TOE1 protein, human 0
USB1 protein, human EC 3.1.4.-
poly(A)-specific ribonuclease EC 3.1.13.4

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

105139

Subventions

Organisme : Howard Hughes Medical Institute
Pays : United States

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest The authors declared no conflict of interest for this review.

Auteurs

Thao Ngoc Huynh (TN)

Department of Biochemistry, University of Colorado Boulder, Boulder, Colorado, USA.

Roy Parker (R)

Department of Biochemistry, University of Colorado Boulder, Boulder, Colorado, USA; Howard Hughes Medical Institute, Chevy Chase, Maryland, USA. Electronic address: Roy.Parker@colorado.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The PARN, TOE1, and USB1 RNA deadenylases and...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies génétiques de la peau › Dyskératose congénitale › The PARN, TOE1, and USB1 RNA deadenylases and...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Ribonucléases › Exoribonucleases › The PARN, TOE1, and USB1 RNA deadenylases and...
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Hémopathies › Troubles leucocytaires › Leucopénie › Agranulocytose › Neutropénie › The PARN, TOE1, and USB1 RNA deadenylases and...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Stabilité de l'ARN › The PARN, TOE1, and USB1 RNA deadenylases and...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › The PARN, TOE1, and USB1 RNA deadenylases and...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutation perte de fonction › The PARN, TOE1, and USB1 RNA deadenylases and...