Beta-subunit-eliminated eHAP expression (BeHAPe) cells reveal subunit regulation of the cardiac voltage-gated sodium channel.
CRISPR/Cas9
cardiac voltage-gated sodium channels
eHAP cells
electrophysiology
gene KO
gene mapping
sodium channel
voltage-gated sodium channel β-subunits
voltage-gated sodium channels
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
10
02
2023
revised:
27
07
2023
accepted:
31
07
2023
medline:
2
10
2023
pubmed:
7
8
2023
entrez:
6
8
2023
Statut:
ppublish
Résumé
Voltage-gated sodium (Na
Identifiants
pubmed: 37544648
pii: S0021-9258(23)02160-9
doi: 10.1016/j.jbc.2023.105132
pmc: PMC10506104
pii:
doi:
Substances chimiques
Intracellular Signaling Peptides and Proteins
0
NAV1.5 Voltage-Gated Sodium Channel
0
Phosphoproteins
0
Protein Subunits
0
Voltage-Gated Sodium Channel beta Subunits
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
105132Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM148239
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH106568
Pays : United States
Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article.