Cat-scratch disease manifesting as uveitis and binocular fundus nodular lesions: a case report.
Bartonella
Cat-scratch disease
Fundus
Metagenomics next-generation sequencing (mNGS)
Ocular manifestations
Journal
BMC ophthalmology
ISSN: 1471-2415
Titre abrégé: BMC Ophthalmol
Pays: England
ID NLM: 100967802
Informations de publication
Date de publication:
07 Aug 2023
07 Aug 2023
Historique:
received:
31
03
2023
accepted:
27
06
2023
medline:
8
8
2023
pubmed:
7
8
2023
entrez:
6
8
2023
Statut:
epublish
Résumé
Cat-scratch disease typically presents with various ocular manifestations such as uveitis, vitritis, retinitis, retinochoroiditis, and optic neuritis. However, fundus nodular lesions was rarely reported. In our study, we reported a case of Cat-Scratch disease with binocular fundus nodular lesions. An 11-year old male presented with uveitis in the right eye and bilateral fundus nodular lesions after indirect contact with unvaccinated cats. Comprehensive ancillary examinations including wide-angle fundus photography, ultrasonography, fluorescein fundus angiography, optical coherence tomography, and orbital magnetic resonance imaging were performed to elucidate the multidimensional features of the binocular lesions. Metagenomics next-generation sequencing was utilized to confirm the diagnosis of Cat-scratch disease. The patient's condition showed improvement after a 6-month combination treatment regimen involving systemic administration of doxycycline hyclate and methylprednisolone tablets, as well as local application of mydriatic and corticosteroid eye drops. We firstly reported a case of Cat-scratch disease presenting simultaneously with uveitis and fundus nodular lesions caused by Bartonella henselae infection in a child. Timely diagnosis and treatment with antibiotics and corticosteroids showed promising outcomes for the prognosis of these ocular disorders.
Sections du résumé
BACKGROUND
BACKGROUND
Cat-scratch disease typically presents with various ocular manifestations such as uveitis, vitritis, retinitis, retinochoroiditis, and optic neuritis. However, fundus nodular lesions was rarely reported. In our study, we reported a case of Cat-Scratch disease with binocular fundus nodular lesions.
CASE PRESENTATION
METHODS
An 11-year old male presented with uveitis in the right eye and bilateral fundus nodular lesions after indirect contact with unvaccinated cats. Comprehensive ancillary examinations including wide-angle fundus photography, ultrasonography, fluorescein fundus angiography, optical coherence tomography, and orbital magnetic resonance imaging were performed to elucidate the multidimensional features of the binocular lesions. Metagenomics next-generation sequencing was utilized to confirm the diagnosis of Cat-scratch disease. The patient's condition showed improvement after a 6-month combination treatment regimen involving systemic administration of doxycycline hyclate and methylprednisolone tablets, as well as local application of mydriatic and corticosteroid eye drops.
CONCLUSIONS
CONCLUSIONS
We firstly reported a case of Cat-scratch disease presenting simultaneously with uveitis and fundus nodular lesions caused by Bartonella henselae infection in a child. Timely diagnosis and treatment with antibiotics and corticosteroids showed promising outcomes for the prognosis of these ocular disorders.
Identifiants
pubmed: 37544996
doi: 10.1186/s12886-023-03063-4
pii: 10.1186/s12886-023-03063-4
pmc: PMC10405493
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
345Informations de copyright
© 2023. BioMed Central Ltd., part of Springer Nature.
Références
Emerg Microbes Infect. 2022 Dec;11(1):1764-1767
pubmed: 35736664
Emerg Infect Dis. 2016 Oct;22(10):1741-6
pubmed: 27648778
J Mol Diagn. 2015 Nov;17(6):623-34
pubmed: 26433313
Eur J Clin Microbiol Infect Dis. 2021 Apr;40(4):849-857
pubmed: 33118059
Ocul Immunol Inflamm. 2018;26(7):1115-1122
pubmed: 28665750
J Clin Exp Hematop. 2012;52(1):1-16
pubmed: 22706525
Vet Res. 2012 Feb 27;43:15
pubmed: 22369683
Pediatrics. 2008 May;121(5):e1413-25
pubmed: 18443019
J Clin Microbiol. 2016 Apr;54(4):1058-64
pubmed: 26865692
J Pediatric Infect Dis Soc. 2021 Mar 26;10(2):213-216
pubmed: 32092135
J Curr Ophthalmol. 2019 May 06;31(3):254-261
pubmed: 31528758
Biomed Environ Sci. 2020 Jan 20;33(1):72-75
pubmed: 32029063
Int Ophthalmol Clin. 2008 Summer;48(3):93-105
pubmed: 18645403
Open Forum Infect Dis. 2021 Oct 05;8(11):ofab500
pubmed: 34926712