Sub-dose anesthetics combined with chloride regulators protect the brain against chronic ischemia-hypoxia injury.
chloride ion
cognitive function
hypoxia
ischemia
propofol
sevoflurane
γ-Aminobutyric acid
Journal
CNS neuroscience & therapeutics
ISSN: 1755-5949
Titre abrégé: CNS Neurosci Ther
Pays: England
ID NLM: 101473265
Informations de publication
Date de publication:
06 Aug 2023
06 Aug 2023
Historique:
revised:
11
07
2023
received:
07
01
2022
accepted:
13
07
2023
medline:
7
8
2023
pubmed:
7
8
2023
entrez:
6
8
2023
Statut:
aheadofprint
Résumé
Cerebral ischemia-hypoxia leads to excitotoxicity-mediated neuronal damage and cognitive dysfunction, especially in the elderly. Excessive intracellular [Cl Chronic cerebral hypoxia (CCH) model was established by bilateral carotid artery ligation in aged rats. Sub-dose of anesthetics (propofol and sevoflurane) with or without KCC2 agonist N-ethylmaleimide (NEM) or Na Sub-anesthetic dose of combined propofol (1.2 μg mL Sub-anesthetic dose of propofol and sevoflurane is a recommended anesthesia regimen in at-risk patients. Restoration of [Cl
Sections du résumé
BACKGROUND
BACKGROUND
Cerebral ischemia-hypoxia leads to excitotoxicity-mediated neuronal damage and cognitive dysfunction, especially in the elderly. Excessive intracellular [Cl
METHODS
METHODS
Chronic cerebral hypoxia (CCH) model was established by bilateral carotid artery ligation in aged rats. Sub-dose of anesthetics (propofol and sevoflurane) with or without KCC2 agonist N-ethylmaleimide (NEM) or Na
RESULTS
RESULTS
Sub-anesthetic dose of combined propofol (1.2 μg mL
CONCLUSION
CONCLUSIONS
Sub-anesthetic dose of propofol and sevoflurane is a recommended anesthesia regimen in at-risk patients. Restoration of [Cl
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 82071220
Organisme : Natural Science Foundation of Tianjin City
ID : 20JCYBJC01290
Organisme : Science and Technology Foundation of Tianjin Health Commission
ID : MS20013
Organisme : Tianjin key Medical Discipline (Specialty) Construction Project.
ID : TJYXZDXK-072C
Organisme : Tianjin Multiple Investment Foundation of Applied Basic Research
ID : 21JCQNJC01020
Informations de copyright
© 2023 The Authors. CNS Neuroscience & Therapeutics Published by John Wiley & Sons Ltd.
Références
Rius-Pérez S, Tormos AM, Pérez S, Taléns-Visconti R. Vascular pathology: cause or effect in Alzheimer disease? Neurologia. 2018;33:112-120.
Bandera E, Botteri M, Minelli C, Sutton A, Abrams KR, Latronico N. Cerebral blood flow threshold of ischemic penumbra and infarct core in acute ischemic stroke: a systematic review. Stroke. 2006;37:1334-1339.
Zhu H, Yoshimoto T, Imajo-Ohmi S, Dazortsava M, Mathivanan A, Yamashima T. Why are hippocampal CA1 neurons vulnerable but motor cortex neurons resistant to transient ischemia? J Neurochem. 2012;120:574-585.
Matveychuk D, MacKenzie EM, Kumpula D, et al. Overview of the neuroprotective effects of the MAO-inhibiting antidepressant phenelzine. Cell Mol Neurobiol. 2021;42:225-242.
Gamba G. Molecular physiology and pathophysiology of electroneutral cation-chloride cotransporters. Physiol Rev. 2005;85:423-493.
Russell JM. Sodium-potassium-chloride cotransport. Physiol Rev. 2000;80:211-276.
Chinn GA, Sasaki Russell JM, Yabut NA, Maharjan D, Sall JW. Androgenic modulation of the chloride transporter NKCC1 contributes to age-dependent isoflurane neurotoxicity in male rats. Anesthesiology. 2020;133:852-866.
Bi D, Wen L, Wu Z, Shen Y. GABAergic dysfunction in excitatory and inhibitory (E/I) imbalance drives the pathogenesis of Alzheimer's disease. Alzheimers Dement. 2020;16:1312-1329.
Pozzi D, Rasile M, Corradini I, Matteoli M. Environmental regulation of the chloride transporter KCC2: switching inflammation off to switch the GABA on? Transl Psychiatry. 2020;10:349.
Engin E, Benham RS, Rudolph U. An emerging circuit pharmacology of GABA receptors. Trends Pharmacol Sci. 2018;39:710-732.
Liu L, Li C-j, Lu Y, et al. Baclofen mediates neuroprotection on hippocampal CA1 pyramidal cells through the regulation of autophagy under chronic cerebral hypoperfusion. Sci Rep. 2015;5:14474.
Zhao Z-F, Du L, Gao T, et al. Inhibition of α5 GABAA receptors has preventive but not therapeutic effects on isoflurane-induced memory impairment in aged rats. Neural Regen Res. 2019;14:1029-1036.
Bu X, Li T, Wang H, et al. Combination of isoflurane and propofol as general anesthesia during orthopedic surgery of perioperative cerebral hypoperfusion rats to avoid cognitive impairment. Front Med. 2020;7:549081.
Brioni JD, Varughese S, Ahmed R, Bein B. A clinical review of inhalation anesthesia with sevoflurane: from early research to emerging topics. J Anesth. 2017;31:764-778.
Wang H, Liu S, Wang H, Wang G, Zhu A. The effect of propofol postconditioning on the expression of K(+)-Cl(−)-co-transporter 2 in GABAergic inhibitory interneurons of acute ischemia/reperfusion injury rats. Brain Res. 2015;1597:210-219.
Yang C-Y, Liu S-Y, Wang H-Y, et al. Neuroprotection by propofol post-conditioning: focus on PKMζ/KCC2 pathway activity. Cell Mol Neurobiol. 2018;38:691-701.
Mitroshina ЕV, Mishchenko TA, Usenko AV, et al. AAV-syn-BDNF-EGFP virus construct exerts neuroprotective action on the hippocampal neural network during hypoxia in vitro. Int J Mol Sci. 2018;19:19.
Turovskaya MV, Gaidin SG, Vedunova MV, Babaev AA, Turovsky EA. BDNF overexpression enhances the preconditioning effect of brief episodes of hypoxia, promoting survival of GABAergic neurons. Neurosci Bull. 2020;36:733-760.
Ben-Ari Y. NKCC1 chloride importer antagonists attenuate many neurological and psychiatric disorders. Trends Neurosci. 2017;40:536-554.
Conway LC, Cardarelli RA, Moore YE, et al. Ethylmaleimide increases KCC2 cotransporter activity by modulating transporter phosphorylation. J Biol Chem. 2017;292:21253-21263.
Brewer GJ, Torricelli JR. Isolation and culture of adult neurons and neurospheres. Nat Protoc. 2007;2:1490-1498.
Hofmeijer J, Mulder ATB, Farinha AC, van Putten MJAM, le Feber J. Mild hypoxia affects synaptic connectivity in cultured neuronal networks. Brain Res. 2014;1557:180-189.
Perry JSA, Morioka S, Medina CB, et al. Interpreting an apoptotic corpse as anti-inflammatory involves a chloride sensing pathway. Nat Cell Biol. 2019;21:1532-1543.
Wang J, Yang C, Wang H, et al. A new rat model of chronic cerebral hypoperfusion resulting in early-stage vascular cognitive impairment. Front Aging Neurosci. 2020;12:86.
Lu K-T, Wu C-Y, Cheng N-C, et al. Inhibition of the Na+ -K+ -2Cl- -cotransporter in choroid plexus attenuates traumatic brain injury-induced brain edema and neuronal damage. Eur J Pharmacol. 2006;548:548-105.
O'Donnell ME, Tran L, Lam TI, Liu XB, Anderson SE. Bumetanide inhibition of the blood-brain barrier Na-K-Cl cotransporter reduces edema formation in the rat middle cerebral artery occlusion model of stroke. J Cerebral Blood Flow Metabol. 2004;24:1046-1056.
Sánchez-Mendoza ME, López-Lorenzo Y, Cruz-Antonio L, Cruz-Oseguera A, García-Machorro J, Arrieta J. Gastroprotective effect of Juanislamin on ethanol-induced gastric lesions in rats: role of prostaglandins, nitric oxide and sulfhydryl groups in the mechanism of action. Molecules. 2020;25:2246.
Yamamoto H, Okada N, Yano I, Murano T. Studies on pharmacodynamic action of N-ethylmaleimide (NEM). 2. An inflammatory property of NEM in rats. Jpn J Pharmacol. 1973;23:161-166.
Korol SV, Tafreshiha A, Bhandage AK, Birnir B, Jin Z. Insulin enhances GABA receptor-mediated inhibitory currents in rat central amygdala neurons. Neurosci Lett. 2018;671:76-81.
Iadecola C, Duering M, Hachinski V, et al. Vascular cognitive impairment and dementia: JACC scientific expert panel. J Am Coll Cardiol. 2019;73:3326-3344.
Belrose JC, Noppens RR. Anesthesiology and cognitive impairment: a narrative review of current clinical literature. BMC Anesthesiol. 2019;19:241.
Mahli A, Coskun D, Karaca GI, Akcali DT, Karabiyik L, Karadenizli Y. Target-controlled infusion of remifentanil with propofol or desflurane under bispectral index guidance: quality of anesthesia and recovery profile. J Res Med Sci. 2011;16:611-620.
Logginidou HG, Li B-H, Li D-P, et al. Propofol suppresses the cortical somatosensory evoked potential in rats. Anesth Analg. 2003;97:1784-1788.
Wang H-y, Wang G-l, Yu Y-h, Wang Y. The role of phosphoinositide-3-kinase/Akt pathway in propofol-induced postconditioning against focal cerebral ischemia-reperfusion injury in rats. Brain Res. 2009;1297:177-184.
Thal SC, Timaru-Kast R, Wilde F, et al. Propofol impairs neurogenesis and neurologic recovery and increases mortality rate in adult rats after traumatic brain injury. Crit Care Med. 2014;42:129-141.
Gómez de Segura IA, de la Vibora JB, Aguado D. Opioid tolerance blunts the reduction in the sevoflurane minimum alveolar concentration produced by remifentanil in the rat. Anesthesiology. 2009;110:1133-1138.
Zhang D-X, Jiang S, Yu L-N, Zhang F-J, Zhuang Q, Yan M. The effect of sevoflurane on the cognitive function of rats and its association with the inhibition of synaptic transmission. Int J Clin Exp Med. 2015;8:20853-20860.
Tian Y, Chen K-Y, Liu L-D, Dong Y-X, Zhao P, Guo S-B. Sevoflurane exacerbates cognitive impairment induced by a in rats through initiating neurotoxicity, neuroinflammation, and neuronal apoptosis in rat hippocampus. Mediators Inflamm. 2018;2018:3802324.
Bu X, Li T, Guo D, et al. 1% isoflurane and 1.2 μg/ml of propofol: a combination of anesthetics that causes the least damage to hypoxic neurons. Front Aging Neurosci. 2020;12:591938.
Johnston MV, Trescher WH, Ishida A, Nakajima W. Neurobiology of hypoxic-ischemic injury in the developing brain. Pediatr Res. 2001;49:735-741.
Edwards AB, Anderton RS, Knuckey NW, Meloni BP. Perinatal hypoxic-ischemic encephalopathy and neuroprotective peptide therapies: a case for cationic arginine-rich peptides (CARPs). Brain Sci. 2018;8:8.
Blauwblomme T, Dzhala V, Staley K. Transient ischemia facilitates neuronal chloride accumulation and severity of seizures. Annals Clin Transl Neurol. 2018;5:1048-1061.
Allen NJ, Rossi DJ, Attwell D. Sequential release of GABA by exocytosis and reversed uptake leads to neuronal swelling in simulated ischemia of hippocampal slices. J Neurosci. 2004;24:3837-3849.
Gao TM, Pulsinelli WA, Xu ZC. Changes in membrane properties of CA1 pyramidal neurons after transient forebrain ischemia in vivo. Neuroscience. 1999;90:771-780.
Xie S, Yu L, Zhou M, Liu L, Lei D, Han C. Association between BDNF rs6265 polymorphisms and postoperative cognitive dysfunction in Chinese Han population. Brain Behavior. 2020;10:e01800.
Qiu L-L, Pan W, Luo D, et al. Dysregulation of BDNF/TrkB signaling mediated by NMDAR/Ca/calpain might contribute to postoperative cognitive dysfunction in aging mice. J Neuroinflammation. 2020;17:23.
Reichardt LF. Neurotrophin-regulated signalling pathways. Philosophical transactions of the Royal Society of London. Series B. Biol Sci. 2006;361:1545-1564.
Ludwig A, Uvarov P, Soni S, Thomas-Crusells J, Airaksinen MS, Rivera C. Early growth response 4 mediates BDNF induction of potassium chloride cotransporter 2 transcription. J Neurosci. 2011;31:644-649.
Szymanski J, Minichiello L. NKCC1 deficiency in forming hippocampal circuits triggers neurodevelopmental disorder: role of BDNF-TrkB Signalling. Brain Sci. 2022;12:12.
Hu J-J, Yang X-L, Luo W-D, et al. Bumetanide reduce the seizure susceptibility induced by pentylenetetrazol via inhibition of aberrant hippocampal neurogenesis in neonatal rats after hypoxia-ischemia. Brain Res Bull. 2017;130:188-199.
Taubes A, Nova P, Zalocusky KA, et al. Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer's disease. Nat Aging. 2021;1:932-947.
Heubl M, Zhang J, Pressey JC, et al. GABA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl-sensitive WNK1 kinase. Nat Commun. 2017;8:1776.
Lombardi A, Jedlicka P, Luhmann HJ, Kilb W. Interactions between membrane resistance, GABA-A receptor properties, bicarbonate dynamics and Cl-transport shape activity-dependent changes of intracellular Cl concentration. Int J Mol Sci. 2019;20:20.
Cikic S, Chandra PK, Harman JC, et al. Sexual differences in mitochondrial and related proteins in rat cerebral microvessels: a proteomic approach. J Cerebral Blood Flow Metabol. 2021;41:397-412.
Wang R, Oh JM, Motovylyak A, et al. Impact of sex and APOE ε4 on age-related cerebral perfusion trajectories in cognitively asymptomatic middle-aged and older adults: a longitudinal study. J Cerebral Blood Flow Metabol. 2021;41:3016-3027.
Chandra PK, Cikic S, Baddoo MC, et al. Transcriptome analysis reveals sexual disparities in gene expression in rat brain microvessels. J Cerebral Blood Flow Metabol. 2021;41:2311-2328.