Carbohydrate sulfotransferases: a review of emerging diagnostic and prognostic applications.

cancer carbohydrate sulfotransferases connective tissue inflammation tumour markers

Journal

Biochemia medica
ISSN: 1846-7482
Titre abrégé: Biochem Med (Zagreb)
Pays: Croatia
ID NLM: 9610305

Informations de publication

Date de publication:
15 Oct 2023
Historique:
received: 07 03 2023
accepted: 19 06 2023
medline: 8 8 2023
pubmed: 7 8 2023
entrez: 7 8 2023
Statut: ppublish

Résumé

Carbohydrate sulfotransferases (CHST) catalyse the biosynthesis of proteoglycans that enable physical interactions and signalling between different neighbouring cells in physiological and pathological states. The study aim was to provide an overview of emerging diagnostic and prognostic applications of CHST. PubMed database search was conducted using the keywords "carbohydrate sulfotransferase" together with appropriate inclusion and exclusion criteria, whereby 41 publications were selected. Additionally, 40 records on CHST genetic and biochemical properties were hand-picked from UniProt, GeneCards, InterPro, and neXtProt databases. Carbohydrate sulfotransferases have been applied mainly in diagnostics of connective tissue disorders, cancer and inflammations. The lack of CHST activity was found in congenital connective tissue disorders while CHST overexpression was detected in different malignancies. Mutations of

Identifiants

pubmed: 37545696
doi: 10.11613/BM.2023.030503
pii: bm-33-3-030503
pmc: PMC10373059
doi:

Substances chimiques

Sulfotransferases EC 2.8.2.-

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

030503

Informations de copyright

Croatian Society of Medical Biochemistry and Laboratory Medicine.

Déclaration de conflit d'intérêts

Potential conflict of interest None declared.

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Auteurs

Gramos Begolli (G)

Clinic of medical biochemistry, University clinical center of Kosovo, Prishtina, Kosovo.

Ivana Marković (I)

Clinical institute of laboratory diagnostics, University hospital centre Osijek, Osijek, Croatia.
Faculty of medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.

Jelena Knežević (J)

Laboratory for advanced genomics, Ruđer Bošković Institute, Zagreb, Croatia.
Faculty for dental medicine and health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.

Željko Debeljak (Ž)

Clinical institute of laboratory diagnostics, University hospital centre Osijek, Osijek, Croatia.
Faculty of medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.

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Classifications MeSH