Human retinal secretome: A cross-link between mesenchymal and retinal cells.
Extracellular vesicles
Mesenchymal stem cells
Retinal cells
Retinal diseases
Secretome
Journal
World journal of stem cells
ISSN: 1948-0210
Titre abrégé: World J Stem Cells
Pays: United States
ID NLM: 101535826
Informations de publication
Date de publication:
26 Jul 2023
26 Jul 2023
Historique:
received:
23
12
2022
revised:
17
03
2023
accepted:
10
04
2023
medline:
7
8
2023
pubmed:
7
8
2023
entrez:
7
8
2023
Statut:
ppublish
Résumé
In recent years, mesenchymal stem cells (MSC) have been considered the most effective source for regenerative medicine, especially due to released soluble paracrine bioactive components and extracellular vesicles. These factors, collectively called the secretome, play crucial roles in immunomodulation and in improving survival and regeneration capabilities of injured tissue. Recently, there has been a growing interest in the secretome released by retinal cytotypes, especially retinal pigment epithelium and Müller glia cells. The latter trophic factors represent the key to preserving morphofunctional integrity of the retina, regulating biological pathways involved in survival, function and responding to injury. Furthermore, these factors can play a pivotal role in onset and progression of retinal diseases after damage of cell secretory function. In this review, we delineated the importance of cross-talk between MSCs and retinal cells, focusing on common/induced secreted factors, during experimental therapy for retinal diseases. The cross-link between the MSC and retinal cell secretomes suggests that the MSC secretome can modulate the retinal cell secretome and vice versa. For example, the MSC secretome can protect retinal cells from degeneration by reducing oxidative stress, autophagy and programmed cell death. Conversely, the retinal cell secretome can influence the MSC secretome by inducing changes in MSC gene expression and phenotype.
Identifiants
pubmed: 37545752
doi: 10.4252/wjsc.v15.i7.665
pmc: PMC10401416
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
665-686Informations de copyright
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: The authors declare no conflicts of interest for this article.
Références
Int J Mol Sci. 2022 Apr 19;23(9):
pubmed: 35562878
Biomolecules. 2021 Apr 23;11(5):
pubmed: 33922434
Int J Reprod Biomed. 2022 Jan 12;19(12):1037-1044
pubmed: 35098005
Stem Cell Res Ther. 2021 Oct 30;12(1):561
pubmed: 34717769
Sci Rep. 2022 Jul 26;12(1):12694
pubmed: 35882889
Stem Cells Int. 2020 Jun 27;2020:9463548
pubmed: 32676122
Cells. 2022 Nov 21;11(22):
pubmed: 36429124
Int J Mol Sci. 2019 Sep 17;20(18):
pubmed: 31533317
Transl Vis Sci Technol. 2022 Oct 3;11(10):1
pubmed: 36180031
Front Cell Neurosci. 2021 Feb 26;15:638098
pubmed: 33716674
ACS Omega. 2020 Aug 12;5(33):21113-21126
pubmed: 32875248
Transplant Proc. 2010 Mar;42(2):566-9
pubmed: 20304194
Cell Prolif. 2021 Nov;54(11):e13129
pubmed: 34585454
Invest Ophthalmol Vis Sci. 2022 Apr 1;63(4):27
pubmed: 35486068
Methods Mol Biol. 2010;660:65-84
pubmed: 20680813
Hum Cell. 2023 Jan;36(1):62-75
pubmed: 36261702
Neurosci Lett. 2022 Mar 16;773:136511
pubmed: 35143889
Glia. 2021 Jul;69(7):1679-1693
pubmed: 33683746
Theranostics. 2020 Jun 5;10(16):7260-7272
pubmed: 32641991
Invest Ophthalmol Vis Sci. 2010 Jul;51(7):3379-86
pubmed: 20207970
Curr Gene Ther. 2021;21(5):382-405
pubmed: 34533444
Mol Neurobiol. 2019 Mar;56(3):1812-1824
pubmed: 29931510
Invest Ophthalmol Vis Sci. 2021 Jul 1;62(9):32
pubmed: 34293080
J Comp Neurol. 2022 Jun;530(8):1213-1230
pubmed: 34729776
Acta Ophthalmol. 2010 Sep;88(6):652-9
pubmed: 20039857
Biochemistry (Mosc). 2019 Nov;84(11):1375-1389
pubmed: 31760924
Int J Mol Sci. 2019 May 31;20(11):
pubmed: 31159345
Adv Sci (Weinh). 2021 Feb 24;8(7):2002944
pubmed: 33854883
Biochem Biophys Res Commun. 2019 Aug 6;515(4):524-530
pubmed: 31176487
Cell Death Dis. 2022 Nov 25;13(11):996
pubmed: 36433947
Neurology. 2021 Feb 16;96(7):e1012-e1023
pubmed: 33472925
Exp Eye Res. 2021 Jul;208:108622
pubmed: 34022176
Cells. 2021 Dec 06;10(12):
pubmed: 34943941
Exp Eye Res. 2022 Jan;214:108857
pubmed: 34856207
Int J Mol Sci. 2021 Nov 13;22(22):
pubmed: 34830165
Front Vet Sci. 2022 Oct 20;9:957153
pubmed: 36337202
Stem Cell Res Ther. 2022 Aug 13;13(1):414
pubmed: 35964139
Stem Cell Reports. 2023 Jan 10;18(1):190-204
pubmed: 36493779
World J Pediatr. 2014 Aug;10(3):262-70
pubmed: 25124978
Front Immunol. 2021 Dec 02;12:751021
pubmed: 34925326
Transl Vis Sci Technol. 2021 Sep 1;10(11):15
pubmed: 34520511
PLoS One. 2012;7(1):e30365
pubmed: 22291943
Int J Mol Sci. 2020 May 03;21(9):
pubmed: 32375269
Cell Mol Life Sci. 2021 Jan;78(2):447-467
pubmed: 32699947
Brain. 2014 Feb;137(Pt 2):503-19
pubmed: 24176979
Prog Retin Eye Res. 2014 Sep;42:44-84
pubmed: 24984227
Life (Basel). 2021 Dec 28;12(1):
pubmed: 35054437
Stem Cells Int. 2020 Nov 05;2020:2853650
pubmed: 33204276
Arthritis Res Ther. 2022 Nov 28;24(1):260
pubmed: 36443838
Mol Vis. 2017 Jul 17;23:431-446
pubmed: 28761317
Lab Invest. 2013 Jan;93(1):81-95
pubmed: 23212098
PLoS One. 2022 Dec 9;17(12):e0278857
pubmed: 36490268
Curr Mol Med. 2010 Apr;10(3):267-78
pubmed: 20236057
Braz J Med Biol Res. 2022 Dec 02;55:e12343
pubmed: 36477953
Cell Transplant. 2014;23(10):1169-85
pubmed: 23768775
Front Neurosci. 2021 Feb 26;15:641157
pubmed: 33716657
Cancer Sci. 2020 Sep;111(9):3100-3110
pubmed: 32639675
Eur Cell Mater. 2021 Jul 8;42:1-19
pubmed: 34235715
Tissue Eng Part A. 2022 May;28(9-10):433-446
pubmed: 34693750
Cell Death Dis. 2018 Feb 13;9(2):218
pubmed: 29440630
Cell Transplant. 2021 Jan-Dec;30:9636897211035715
pubmed: 34559583
Biochim Biophys Acta Mol Basis Dis. 2020 Dec 1;1866(12):165956
pubmed: 32877751
Biologicals. 2022 Apr;76:24-30
pubmed: 35216916
J Extracell Vesicles. 2022 Sep;11(9):e12254
pubmed: 36043482
Curr Stem Cell Res Ther. 2011 Jun;6(2):82-92
pubmed: 21190538
Front Cell Dev Biol. 2021 Sep 16;9:717772
pubmed: 34604216
Exp Eye Res. 2009 Nov;89(5):629-37
pubmed: 19540231
Int Immunopharmacol. 2021 Aug;97:107823
pubmed: 34102486
J Biomed Biotechnol. 2011;2011:901329
pubmed: 21860587
Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):5507-5517
pubmed: 29075761
Clin Exp Ophthalmol. 2019 Dec;47(9):1182-1197
pubmed: 31483932
Cytokine. 2017 Jul;95:126-135
pubmed: 28282610
J Immunol Res. 2022 Apr 6;2022:6792866
pubmed: 35434141
J Neuroinflammation. 2019 Sep 12;16(1):178
pubmed: 31514749
Yonsei Med J. 2001 Jun;42(3):271-7
pubmed: 11456391
Stem Cell Res. 2021 May;53:102272
pubmed: 33676128
Exp Eye Res. 2021 Apr;205:108528
pubmed: 33662356
Biochem Biophys Res Commun. 2006 Jun 9;344(3):912-9
pubmed: 16631611
J Cell Physiol. 2021 May;236(5):3918-3928
pubmed: 33145762
Int J Mol Sci. 2014 Mar 07;15(3):4142-57
pubmed: 24608926
Yakugaku Zasshi. 2021;141(1):41-45
pubmed: 33390446
Drug Des Devel Ther. 2020 Mar 26;14:1241-1256
pubmed: 32273686
Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1892-9
pubmed: 17389525
Expert Opin Biol Ther. 2020 Feb;20(2):125-140
pubmed: 31701782
Sci Rep. 2021 May 26;11(1):10962
pubmed: 34040115
Neurol Sci. 2019 Feb;40(2):243-251
pubmed: 30523548
Exp Eye Res. 2021 Aug;209:108689
pubmed: 34216615
Life Sci. 2023 Jan 1;312:121206
pubmed: 36403645
Cells. 2022 Aug 29;11(17):
pubmed: 36078094
Aging Cell. 2021 May;20(5):e13340
pubmed: 33783931
Curr Stem Cell Res Ther. 2021;16(4):443-453
pubmed: 33092514
Stem Cell Res Ther. 2020 Mar 4;11(1):97
pubmed: 32127037
J Mol Med (Berl). 2020 Oct;98(10):1347-1368
pubmed: 32794020
Int J Mol Sci. 2021 Jul 05;22(13):
pubmed: 34281287
Diabetologia. 2021 Jan;64(1):211-225
pubmed: 33104828
Front Cell Dev Biol. 2021 Jan 21;9:630645
pubmed: 33553187
Acta Biomater. 2017 Apr 15;53:293-306
pubmed: 28213098
J Transl Med. 2021 Nov 4;19(1):456
pubmed: 34736500
Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5495-503
pubmed: 19516002
Exp Eye Res. 2020 Nov;200:108214
pubmed: 32898511
PLoS One. 2017 Sep 8;12(9):e0183775
pubmed: 28886036
Stem Cell Res Ther. 2020 Nov 27;11(1):511
pubmed: 33246507
Int J Mol Sci. 2022 Jul 13;23(14):
pubmed: 35887093
Front Immunol. 2019 Feb 05;10:18
pubmed: 30804924
Ophthalmic Res. 2022;65(5):556-565
pubmed: 35584686
Biofabrication. 2021 Jul 08;13(4):
pubmed: 34111862
Rev Neurosci. 2019 Nov 26;30(8):839-855
pubmed: 31203262
Retina. 2006 Apr;26(4):454-61
pubmed: 16603966
J Tissue Eng Regen Med. 2014 May;8(5):407-13
pubmed: 22674835
Adv Biol (Weinh). 2021 Apr;5(4):e2000271
pubmed: 33852181
Saudi J Biol Sci. 2021 Aug;28(8):4399-4407
pubmed: 34354424
ACS Nano. 2022 Jan 25;16(1):869-884
pubmed: 34985280
J Comput Biol. 2020 Aug;27(8):1329-1336
pubmed: 31841640
Cells. 2021 Aug 20;10(8):
pubmed: 34440909
Antioxidants (Basel). 2021 May 25;10(6):
pubmed: 34070383
Biochimie. 2023 Apr;207:33-48
pubmed: 36427681
Int J Mol Sci. 2018 Oct 09;19(10):
pubmed: 30304871
Mol Biol Rep. 2020 Jun;47(6):4413-4425
pubmed: 32385771
Dev Dyn. 2012 Mar;241(3):595-607
pubmed: 22275161
Life Sci. 2022 Jul 1;300:120570
pubmed: 35469914
In Vitro Cell Dev Biol Anim. 2020 Oct;56(9):689-700
pubmed: 33006709
Int J Med Sci. 2020 Feb 24;17(5):657-663
pubmed: 32210716
Cytokine. 2019 Apr;116:70-77
pubmed: 30685605
Stem Cell Res Ther. 2020 Jan 28;11(1):38
pubmed: 31992369
Front Neurol. 2017 Feb 20;8:28
pubmed: 28265255
Antioxidants (Basel). 2022 Sep 30;11(10):
pubmed: 36290689
Mol Ther Methods Clin Dev. 2020 May 13;17:1155-1166
pubmed: 32514411
J Pathol. 2022 Jul;257(3):327-339
pubmed: 35254670
Inflamm Regen. 2022 Nov 30;42(1):55
pubmed: 36451229
Proteomics. 2018 Jun;18(11):e1700321
pubmed: 29645351
Cell Rep. 2019 Nov 26;29(9):2702-2717.e7
pubmed: 31775039
Front Pharmacol. 2021 Oct 29;12:771571
pubmed: 34776983
Exp Cell Res. 2020 Dec 15;397(2):112347
pubmed: 33130176
J Cell Mol Med. 2020 Jul;24(13):7515-7530
pubmed: 32424968
Cytokine Growth Factor Rev. 2018 Feb;39:102-115
pubmed: 29248329
iScience. 2020 Jun 26;23(6):101184
pubmed: 32502964
Stem Cell Res Ther. 2015 Jul 01;6:127
pubmed: 26129847
Biomolecules. 2021 Jan 16;11(1):
pubmed: 33467052
Diabetes. 2015 Oct;64(10):3554-63
pubmed: 26068541
Cells. 2020 May 20;9(5):
pubmed: 32443855
World J Stem Cells. 2020 Dec 26;12(12):1529-1552
pubmed: 33505599
Eur J Pharmacol. 2019 Jan 5;842:329-337
pubmed: 30395849
J Mol Cell Cardiol. 2019 Jun;131:171-186
pubmed: 31055035
Artif Cells Nanomed Biotechnol. 2020 Dec;48(1):1160-1167
pubmed: 32902361
Cytokine Growth Factor Rev. 2019 Apr;46:1-9
pubmed: 30954374
Infect Immun. 2021 Jul 15;89(8):e0014121
pubmed: 34031126
Stem Cells Cloning. 2022 Apr 14;15:1-9
pubmed: 35444427
Life Sci. 2022 Mar 15;293:120089
pubmed: 35007563
Sci Rep. 2018 Feb 1;8(1):2161
pubmed: 29391474
Exp Eye Res. 2022 Feb;215:108930
pubmed: 35016886
Sci Rep. 2019 Oct 28;9(1):15440
pubmed: 31659173
Adv Exp Med Biol. 2019;1185:445-449
pubmed: 31884652
Diabetes. 2007 May;56(5):1333-40
pubmed: 17470563
Cells. 2022 Oct 25;11(21):
pubmed: 36359762
J Extracell Vesicles. 2021 Nov;10(13):e12165
pubmed: 34750957
J Cell Commun Signal. 2019 Dec;13(4):451-462
pubmed: 30607767
Int J Mol Sci. 2020 Dec 31;22(1):
pubmed: 33396450
Diabetes Res Clin Pract. 2023 Jan;195:110201
pubmed: 36493913
J Tissue Eng Regen Med. 2022 Nov;16(11):1008-1018
pubmed: 36017672