Trans-cinnamaldehyde loaded chitosan based nanocapsules display antibacterial and antibiofilm effects against cavity-causing
Streptococcus mutans
antibacterial agents
antibiofilm
chitosan
cinnamaldehyde
dental caries
nanocapsules
Journal
Journal of oral microbiology
ISSN: 2000-2297
Titre abrégé: J Oral Microbiol
Pays: United States
ID NLM: 101551049
Informations de publication
Date de publication:
2023
2023
Historique:
medline:
7
8
2023
pubmed:
7
8
2023
entrez:
7
8
2023
Statut:
epublish
Résumé
Dental caries is a multifactorial disease, and the bacteria such as To address this concern, we report here on the cinnamaldehyde (CA) loaded chitosan (CS) nanocapsules (CA@CS NC) sustained release CA for antibacterial treatment. The size, ζ-potential, and morphology were characterized. The antibacterial activities in vitro were studied by growth curve assay, pH drop assay, biofilm assay, and qRT-PCR In addition, cytotoxicity assay, organ index, body weight, and histopathology results were analyzed to evaluate the safety and biocompatibility in a rat model. CA@CS NC can adsorb the bacterial membrane due to electronic interaction, releasing CA slowly for a long time. At the same time, it has reliable antibacterial activity against Our results showed that CA@CS NC had antibacterial and antibiofilm effects on
Sections du résumé
Background
UNASSIGNED
Dental caries is a multifactorial disease, and the bacteria such as
Methods
UNASSIGNED
To address this concern, we report here on the cinnamaldehyde (CA) loaded chitosan (CS) nanocapsules (CA@CS NC) sustained release CA for antibacterial treatment. The size, ζ-potential, and morphology were characterized. The antibacterial activities in vitro were studied by growth curve assay, pH drop assay, biofilm assay, and qRT-PCR In addition, cytotoxicity assay, organ index, body weight, and histopathology results were analyzed to evaluate the safety and biocompatibility in a rat model.
Results
UNASSIGNED
CA@CS NC can adsorb the bacterial membrane due to electronic interaction, releasing CA slowly for a long time. At the same time, it has reliable antibacterial activity against
Conclusion
UNASSIGNED
Our results showed that CA@CS NC had antibacterial and antibiofilm effects on
Identifiants
pubmed: 37546377
doi: 10.1080/20002297.2023.2243067
pii: 2243067
pmc: PMC10402844
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2243067Informations de copyright
© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Déclaration de conflit d'intérêts
No potential conflict of interest was reported by the author(s).
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