Whipple's Disease; An Overlooked Diagnosis.
COVID-19
Malabsorption syndrome
Whipple disease
Journal
Middle East journal of digestive diseases
ISSN: 2008-5230
Titre abrégé: Middle East J Dig Dis
Pays: Iran
ID NLM: 101535395
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
received:
20
06
2022
accepted:
08
01
2023
medline:
7
8
2023
pubmed:
7
8
2023
entrez:
7
8
2023
Statut:
ppublish
Résumé
Whipple disease is a rare multisystem inflammatory disease. Because fewer than 1000 reported cases have been described, clinical experience with this disorder is sparse. We are reporting a case of a 46-year-old man who presented with fever, weight loss, and polyarthralgia for 2 months, and 1 month of diarrhea. The patient was thoroughly investigated for collagen diseases and COVID-19, with no definite diagnosis. A therapeutic trial by immunosuppressive drugs provided partial remission followed by a marked rebound of the symptoms. His occult blood in stool was positive and subsequent upper endoscopy with proximal small intestinal biopsies showed the pathological features of Whipple's disease. The patient showed a dramatic improvement following treatment with ceftriaxone and trimethoprim-sulfamethoxazole. Despite the rarity of Whipple's disease, its course mimics many rheumatological diseases, inflammatory bowel disease, and COVID-19 disease. It should always be a part of the differential diagnosis of obscure polyarthralgia and chronic diarrhea.
Identifiants
pubmed: 37546505
doi: 10.34172/mejdd.2023.333
pmc: PMC10404087
doi:
Types de publication
Case Reports
Langues
eng
Pagination
136-138Informations de copyright
© 2023 Middle East Journal of Digestive Diseases.
Déclaration de conflit d'intérêts
Competing Interests The authors declare no conflict of interest related to this work.
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