Diagnosis and management of adult central nervous system leukemia.

Central nervous system leukemia Prophylaxis Risk factors Treatment

Journal

Blood science (Baltimore, Md.)
ISSN: 2543-6368
Titre abrégé: Blood Sci
Pays: United States
ID NLM: 9918248414306676

Informations de publication

Date de publication:
Jul 2023
Historique:
received: 23 12 2022
accepted: 09 05 2023
medline: 7 8 2023
pubmed: 7 8 2023
entrez: 7 8 2023
Statut: epublish

Résumé

Central nervous system leukemia (CNSL) is a prominent infiltration reason for therapy failing in acute leukemia. Recurrence rates and the prognosis have alleviated with current prophylactic regimens. However, the accurate stratification of relapse risk and treatment regimens for relapsed or refractory patients remain clinical challenges yet to be solved. Recently, with hematopoietic stem cell transplantation (HSCT) and chimeric antigen receptor-T (CAR-T) cellular therapy showing encouraging effects in some CNSL patients, advances in treating CNSL have already been reported. The development of molecular targeted agents as well as antibody-based drugs will provide patients with more personalized treatment. This article summarized recent research developments about risk factors, diagnosis, prevention, and treatment in adults with CNSL.

Identifiants

DOI: 10.1097/BS9.0000000000000162 PMID: 37546706 PMC: PMC10400053
pubmed: 37546706
doi: 10.1097/BS9.0000000000000162
pmc: PMC10400053
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

141-149

Informations de copyright

Copyright © 2023 The Authors. Published by Wolters Kluwer Health Inc., on behalf of the Chinese Medical Association (CMA) and Institute of Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College (IHCAMS).

Déclaration de conflit d'intérêts

Conflict of interest: The authors declare that they have no conflict of interest.

Références

Oncotarget. 2017 Dec 20;9(4):5424-5434
pubmed: 29435190
Leuk Lymphoma. 2007 Sep;48(9):1849-51
pubmed: 17786723
Cancer. 2022 Jun 1;128(11):2138-2147
pubmed: 35315510
Hematology Am Soc Hematol Educ Program. 2006;:142-6
pubmed: 17124053
Semin Hematol. 2018 Oct;55(4):209-214
pubmed: 30502849
Leukemia. 2019 Aug;33(8):2090-2125
pubmed: 30778134
Blood. 2008 Aug 15;112(4):1005-12
pubmed: 18477770
Blood. 2005 Jun 15;105(12):4752-8
pubmed: 15713801
Blood Adv. 2020 May 26;4(10):2325-2338
pubmed: 32453841
Ann Hematol. 2020 Oct;99(10):2393-2404
pubmed: 32803312
Oncologist. 2019 Sep;24(9):1237-1245
pubmed: 30842245
Haematologica. 2019 May;104(5):e222-e223
pubmed: 30765472
Leuk Lymphoma. 2018 Jan;59(1):3-13
pubmed: 28535095
BMC Res Notes. 2014 Sep 13;7:645
pubmed: 25218117
Biol Blood Marrow Transplant. 2016 Mar;22(3):575-8
pubmed: 26493564
Curr Oncol Rep. 2020 Jun 29;22(8):78
pubmed: 32602069
Ann Hematol. 2021 Feb;100(2):505-516
pubmed: 33389025
Cancer. 2006 Jun 15;106(12):2540-6
pubmed: 16700036
J Neuroophthalmol. 2022 Mar 1;42(1):e187-e191
pubmed: 35500239
Drugs. 2022 Mar;82(4):469-475
pubmed: 35195876
Pract Radiat Oncol. 2017 Mar - Apr;7(2):103-108
pubmed: 28274393
Hematology. 2017 Mar;22(2):81-87
pubmed: 27734763
Blood Adv. 2017 Jun 27;1(15):1167-1180
pubmed: 29296758
Am J Hematol. 2023 Jan;98(1):E11-E14
pubmed: 35633516
Blood. 2003 May 15;101(10):3809-17
pubmed: 12531809
Turk J Haematol. 2018 May 25;35(2):147-149
pubmed: 29391330
JAMA Oncol. 2020 Mar 1;6(3):358-366
pubmed: 31944221
Am J Hematol. 2019 Dec;94(12):1388-1395
pubmed: 31595534
Ann Hematol. 2018 Sep;97(9):1627-1632
pubmed: 29707738
Cancer Discov. 2017 Sep;7(9):1018-1029
pubmed: 28619981
J Adolesc Young Adult Oncol. 2020 Apr;9(2):166-171
pubmed: 31747341
Clin Lymphoma Myeloma Leuk. 2015 Aug;15(8):451-7
pubmed: 25816933
Am J Hematol. 2021 Aug 1;96(8):1000-1007
pubmed: 33991360
J Clin Diagn Res. 2016 Jan;10(1):OE01-5
pubmed: 26894118
Semin Oncol. 2009 Aug;36(4 Suppl 2):S2-S16
pubmed: 19660680
Clin Ther. 2021 Jul;43(7):1265-1271.e1
pubmed: 34120773
Ann Hematol. 2022 Mar;101(3):723-724
pubmed: 34235557
Front Genet. 2022 May 12;13:878618
pubmed: 35646048
Blood. 2009 May 14;113(20):5028-9
pubmed: 19443672
Leuk Lymphoma. 2008 Dec;49(12):2298-307
pubmed: 19052977
Neuropathology. 2019 Feb;39(1):54-57
pubmed: 30474266
Biomolecules. 2023 Jan 05;13(1):
pubmed: 36671496
Haematologica. 2011 Feb;96(2):238-44
pubmed: 20952517
Leuk Res. 2021 Jan;100:106480
pubmed: 33285315
Haematologica. 2018 May;103(5):e200-e203
pubmed: 29419426
Blood. 2017 Aug 3;130(5):643-654
pubmed: 28550041
Blood. 2002 Feb 1;99(3):863-71
pubmed: 11806988
J Neurooncol. 2020 Aug;149(1):13-25
pubmed: 32691208
Leukemia. 2000 Dec;14(12):2257-66
pubmed: 11187917
Nature. 2018 Oct;562(7728):605-609
pubmed: 30333625
Haematologica. 2016 Apr;101(4):458-65
pubmed: 26819053
Leuk Lymphoma. 2022 Aug;63(8):1839-1848
pubmed: 35345967
Haematologica. 2022 Mar 01;107(3):635-643
pubmed: 33567813
J Immunother Cancer. 2021 May;9(5):
pubmed: 34035113
Hematol Oncol Stem Cell Ther. 2021 Sep;14(3):240-245
pubmed: 33271117
J Neurooncol. 2018 Aug;139(1):117-123
pubmed: 29633110
Nature. 2018 Aug;560(7716):55-60
pubmed: 30022166
Biol Blood Marrow Transplant. 2018 Mar;24(3):501-506
pubmed: 29191665
Lancet Oncol. 2019 Feb;20(2):216-228
pubmed: 30630772
Int J Hematol. 2016 Jan;103(1):107-11
pubmed: 26586462
Ann Oncol. 2017 Oct 01;28(10):2511-2516
pubmed: 28961838
Anticancer Agents Med Chem. 2018;18(10):1489-1494
pubmed: 29521250
Haematologica. 2015 Jun;100(6):786-93
pubmed: 25749825
Br J Haematol. 2005 Jun;129(6):734-45
pubmed: 15952999
Pediatr Blood Cancer. 2020 Feb;67(2):e27999
pubmed: 31674724
Hematology. 2020 Dec;25(1):258-263
pubmed: 32567523
Leukemia. 2019 Jun;33(6):1313-1323
pubmed: 30546081
Haematologica. 2018 Feb;103(2):e92-e93
pubmed: 29242296
Int J Cancer. 2020 Aug 15;147(4):1071-1077
pubmed: 31785158
Eur J Cancer. 2019 Aug;117:121-130
pubmed: 31279304
Oncogene. 2022 Apr;41(16):2303-2314
pubmed: 35256780
Pract Radiat Oncol. 2019 May;9(3):e283-e289
pubmed: 30578956
Medicine (Baltimore). 2019 May;98(19):e15584
pubmed: 31083240
J Clin Oncol. 2000 Feb;18(3):547-61
pubmed: 10653870
J Clin Oncol. 2017 Jun 1;35(16):1795-1802
pubmed: 28355115
BMC Cancer. 2015 May 02;15:344
pubmed: 25934556
Lancet Oncol. 2015 Jan;16(1):57-66
pubmed: 25524800
Leuk Lymphoma. 2015 May;56(5):1392-7
pubmed: 25110819
Int J Hematol. 2018 Dec;108(6):640-646
pubmed: 30078165
Clin Cancer Res. 2019 Mar 1;25(5):1601-1611
pubmed: 30518632
Cancer. 2022 Apr 1;128(7):1411-1417
pubmed: 34931301
Blood. 2007 Apr 15;109(8):3214-8
pubmed: 17209054
Br J Haematol. 2004 Mar;124(6):762-8
pubmed: 15009064
Bone Marrow Transplant. 2021 Nov;56(11):2842-2848
pubmed: 34331021
Pract Radiat Oncol. 2017 Nov - Dec;7(6):e401-e408
pubmed: 28666906
Curr Oncol Rep. 2022 Apr;24(4):427-436
pubmed: 35141858
J Hematol Oncol. 2020 Sep 7;13(1):122
pubmed: 32894185
Pediatr Blood Cancer. 2017 Dec;64(12):
pubmed: 28233411
J Clin Lab Anal. 2021 Aug;35(8):e23583
pubmed: 34251066
Neurology. 1979 Oct;29(10):1369-75
pubmed: 573381
J Clin Oncol. 1987 Feb;5(2):202-7
pubmed: 3806166
Blood. 2022 Jun 9;139(23):3376-3386
pubmed: 35338773
Lancet Haematol. 2016 May;3(5):e217-27
pubmed: 27132696
Mayo Clin Proc. 2016 Nov;91(11):1645-1666
pubmed: 27814839
Eur J Haematol. 2018 Mar;100(3):279-285
pubmed: 29240262
Cancer. 2004 Dec 15;101(12):2788-801
pubmed: 15481055
Ann Hematol. 2017 Jul;96(7):1069-1075
pubmed: 28451802
Curr Res Transl Med. 2021 Jul;69(3):103296
pubmed: 34139603
Leukemia. 2017 Jan;31(1):255-258
pubmed: 27698445

Auteurs

Siyu Liu (S)

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.

Ying Wang (Y)

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.

Classifications MeSH