APOE4/4 is linked to damaging lipid droplets in Alzheimer's microglia.

Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
25 Jul 2023
Historique:
pubmed: 7 8 2023
medline: 7 8 2023
entrez: 7 8 2023
Statut: epublish

Résumé

Several genetic risk factors for Alzheimer's Disease (AD) implicate genes involved in lipid metabolism and many of these lipid genes are highly expressed in glial cells. However, the relationship between lipid metabolism in glia and AD pathology remains poorly understood. Through single-nucleus RNA-sequencing of AD brain tissue, we have identified a microglial state defined by the expression of the lipid droplet (LD) associated enzyme

Identifiants

DOI: 10.1101/2023.07.21.549930 PMID: 37546938 PMC: PMC10401952
pubmed: 37546938
doi: 10.1101/2023.07.21.549930
pmc: PMC10401952
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIA NIH HHS
ID : T32 AG000266
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072980
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG073082
Pays : United States
Organisme : NINDS NIH HHS
ID : U24 NS072026
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG019610
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG064928
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG069453
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG059307
Pays : United States
Organisme : NIA NIH HHS
ID : R03 AG071791
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066515
Pays : United States

Déclaration de conflit d'intérêts

Competing financial interests T.G.B. is a paid consultant to Aprinoia Therapeutics and Biogen. E.M.R. is a scientific advisor to Alzheon, Aural Analytics, Denali, Retromer Therapeutics, and Vaxxinity and a co-founder and advisor to ALZPath. The other authors declare no competing financial interests.

Auteurs

Michael S Haney (MS)

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.
Equal contribution.

Róbert Pálovics (R)

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.
Equal contribution.

Christy Nicole Munson (CN)

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.

Chris Long (C)

Department of Materials Science & Engineering Department, Stanford University, Stanford, CA 94305, USA.

Patrik Johansson (P)

Department of Materials Science & Engineering Department, Stanford University, Stanford, CA 94305, USA.

Oscar Yip (O)

Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, US.

Wentao Dong (W)

The Institute for Chemistry, Engineering & Medicine for Human Health (ChEM-H), Stanford University, Stanford, CA, USA.

Eshaan Rawat (E)

The Institute for Chemistry, Engineering & Medicine for Human Health (ChEM-H), Stanford University, Stanford, CA, USA.

Elizabeth West (E)

Department of Cellular and Molecular Medicine, University of California, San Diego, San Diego, CA 92093, USA.

Johannes Cm Schlachetzki (JC)

Department of Cellular and Molecular Medicine, University of California, San Diego, San Diego, CA 92093, USA.

Andy Tsai (A)

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.

Ian Hunter Guldner (IH)

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.

Bhawika S Lamichhane (BS)

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.

Amanda Smith (A)

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.

Nicholas Schaum (N)

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.

Kruti Calcuttawala (K)

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.

Andrew Shin (A)

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.

Yung-Hua Wang (YH)

Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, US.

Chengzhong Wang (C)

Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, US.

Nicole Koutsodendris (N)

Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, US.
Development and Stem Cell Biology Graduate Program, University of California, San Francisco, US.

Geidy E Serrano (GE)

Laboratory of Neuropathology, Banner Sun Health Research Institute, Sun City, AZ, USA.

Thomas G Beach (TG)

Banner Alzheimer's Institute and Arizona Alzheimer's Consortium, Phoenix, AZ, USA.

Eric M Reiman (EM)

Banner Alzheimer's Institute and Arizona Alzheimer's Consortium, Phoenix, AZ, USA.

Christopher K Glass (CK)

Development and Stem Cell Biology Graduate Program, University of California, San Francisco, US.

Monther Abu-Remaileh (M)

The Institute for Chemistry, Engineering & Medicine for Human Health (ChEM-H), Stanford University, Stanford, CA, USA.

Annika Enejder (A)

Department of Materials Science & Engineering Department, Stanford University, Stanford, CA 94305, USA.

Yadong Huang (Y)

Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, US.
Biomedical Sciences Graduate Program, University of California, San Francisco, US.
Development and Stem Cell Biology Graduate Program, University of California, San Francisco, US.
Department of Neurology, University of California, San Francisco, CA, USA.

Tony Wyss-Coray (T)

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.
The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.

Classifications MeSH