Acquisition of drug resistance in basal cell nevus syndrome tumors through basal to squamous cell carcinoma transition.
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
27 Jul 2023
27 Jul 2023
Historique:
medline:
7
8
2023
pubmed:
7
8
2023
entrez:
7
8
2023
Statut:
epublish
Résumé
While basal cell carcinomas (BCCs) arise from ectopic hedgehog pathway activation and can be treated with pathway inhibitors, sporadic BCCs display high resistance rates while tumors arising in Gorlin syndrome patients with germline Patched (
Identifiants
pubmed: 37546976
doi: 10.1101/2023.07.26.550719
pmc: PMC10402087
pii:
doi:
Types de publication
Preprint
Langues
eng