Immunometabolism at the Heart of Cardiovascular Disease.
heart failure
immunometabolism
myocardial infarction
Journal
JACC. Basic to translational science
ISSN: 2452-302X
Titre abrégé: JACC Basic Transl Sci
Pays: United States
ID NLM: 101677259
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
received:
05
10
2022
revised:
21
12
2022
accepted:
27
12
2022
medline:
7
8
2023
pubmed:
7
8
2023
entrez:
7
8
2023
Statut:
epublish
Résumé
Immune cell function among the myocardium, now more than ever, is appreciated to regulate cardiac function and pathophysiology. This is the case for both innate immunity, which includes neutrophils, monocytes, dendritic cells, and macrophages, as well as adaptive immunity, which includes T cells and B cells. This function is fueled by cell-intrinsic shifts in metabolism, such as glycolysis and oxidative phosphorylation, as well as metabolite availability, which originates from the surrounding extracellular milieu and varies during ischemia and metabolic syndrome. Immune cell crosstalk with cardiac parenchymal cells, such as cardiomyocytes and fibroblasts, is also regulated by complex cellular metabolic circuits. Although our understanding of immunometabolism has advanced rapidly over the past decade, in part through valuable insights made in cultured cells, there remains much to learn about contributions of in vivo immunometabolism and directly within the myocardium. Insight into such fundamental cell and molecular mechanisms holds potential to inform interventions that shift the balance of immunometabolism from maladaptive to cardioprotective and potentially even regenerative. Herein, we review our current working understanding of immunometabolism, specifically in the settings of sterile ischemic cardiac injury or cardiometabolic disease, both of which contribute to the onset of heart failure. We also discuss current gaps in knowledge in this context and therapeutic implications.
Identifiants
pubmed: 37547069
doi: 10.1016/j.jacbts.2022.12.010
pii: S2452-302X(23)00007-4
pmc: PMC10401297
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
884-904Informations de copyright
© 2023 The Authors.
Références
Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5133-8
pubmed: 23479618
Nat Med. 2011 May;17(5):610-7
pubmed: 21499269
Circulation. 2014 May 27;129(21):2111-24
pubmed: 24657994
J Clin Invest. 2021 May 17;131(10):
pubmed: 33822765
Nature. 2006 Dec 14;444(7121):860-7
pubmed: 17167474
J Bioenerg Biomembr. 2011 Aug;43(4):367-75
pubmed: 21732177
Immunology. 2015 Jun;145(2):213-24
pubmed: 25545227
Circulation. 2005 Nov 15;112(20):3066-72
pubmed: 16275870
Proc Natl Acad Sci U S A. 2012 May 15;109(20):7622-9
pubmed: 22538809
Basic Res Cardiol. 2018 Jun 4;113(4):26
pubmed: 29868933
J Immunol. 2012 Nov 1;189(9):4379-86
pubmed: 23002443
Blood. 2010 Jun 10;115(23):4742-9
pubmed: 20351312
J Card Fail. 2020 Dec;26(12):1050-1059
pubmed: 32750486
Am J Physiol Heart Circ Physiol. 2018 Dec 1;315(6):H1713-H1723
pubmed: 30239234
Nat Cardiovasc Res. 2022 Aug;1(8):761-774
pubmed: 36092510
Circ Shock. 1992 Jun;37(2):105-10
pubmed: 1511500
Science. 2001 Apr 20;292(5516):504-7
pubmed: 11283355
Nature. 2014 Nov 20;515(7527):431-435
pubmed: 25383517
Cell Metab. 2013 Aug 6;18(2):239-50
pubmed: 23931755
Sci Rep. 2020 Aug 31;10(1):14333
pubmed: 32868786
J Exp Med. 2018 Feb 5;215(2):423-440
pubmed: 29339450
J Clin Invest. 2016 Jun 1;126(6):2151-66
pubmed: 27140396
Circ Res. 2014 Jul 7;115(2):284-95
pubmed: 24786973
J Clin Invest. 2001 Oct;108(8):1167-74
pubmed: 11602624
Cell Metab. 2021 Feb 2;33(2):270-282.e8
pubmed: 33278339
Elife. 2016 Feb 19;5:
pubmed: 26894960
Nat Rev Immunol. 2018 Jan;18(1):19-34
pubmed: 28944771
Biomed Pharmacother. 2019 Jun;114:108804
pubmed: 30909146
Front Immunol. 2017 Aug 22;8:958
pubmed: 28878765
Eur J Immunol. 2022 Mar;52(3):418-430
pubmed: 34961940
J Am Coll Cardiol. 2012 Jan 10;59(2):153-63
pubmed: 22222080
J Cell Biol. 2015 Sep 28;210(7):1153-64
pubmed: 26416965
Circulation. 2016 Mar 1;133(9):826-39
pubmed: 26819373
Circulation. 2000 Nov 7;102(19):2329-34
pubmed: 11067784
Science. 2016 Oct 28;354(6311):481-484
pubmed: 27708054
Front Immunol. 2018 Nov 01;9:2489
pubmed: 30455688
Circ Heart Fail. 2017 Mar;10(3):e003688
pubmed: 28242779
Sci Transl Med. 2012 Jun 13;4(138):138ra80
pubmed: 22700956
J Clin Invest. 2011 Mar;121(3):1053-63
pubmed: 21317538
Circulation. 2012 Mar 13;125(10):1234-45
pubmed: 22308302
J Nucl Med. 2009 Aug;50(8):1283-7
pubmed: 19617334
Circ Heart Fail. 2017 Jun;10(6):
pubmed: 28615366
Circ Res. 2014 Jun 20;115(1):55-67
pubmed: 24786398
Diabetes. 2022 Apr 1;71(4):853-861
pubmed: 35073575
Cell Death Dis. 2019 Jul 18;10(8):544
pubmed: 31320613
Circ Cardiovasc Imaging. 2016 Apr;9(4):e004316
pubmed: 27056601
J Immunol. 2018 Sep 15;201(6):1784-1798
pubmed: 30097529
Cell Metab. 2020 Sep 1;32(3):468-478.e7
pubmed: 32791101
J Immunol. 2022 Jul 1;209(1):69-76
pubmed: 35697385
Haematologica. 2019 Mar;104(3):456-467
pubmed: 30361420
Int J Obes (Lond). 2020 Dec;44(12):2419-2429
pubmed: 33037327
J Exp Med. 2017 Nov 6;214(11):3311-3329
pubmed: 28970239
Biomedicines. 2022 Sep 15;10(9):
pubmed: 36140396
Hypertension. 2018 Apr;71(4):709-718
pubmed: 29378857
J Clin Invest. 2020 Nov 2;130(11):6054-6063
pubmed: 32790648
Circ Heart Fail. 2011 Jan;4(1):44-52
pubmed: 21075869
Cell Physiol Biochem. 2018;47(5):1936-1950
pubmed: 29972819
Circ Res. 2020 Jun 5;126(12):1723-1745
pubmed: 32216531
Nat Immunol. 2013 May;14(5):500-8
pubmed: 23525088
Cell Rep. 2017 Oct 24;21(4):1009-1020
pubmed: 29069584
J Mol Cell Cardiol. 2015 Oct;87:171-9
pubmed: 26316303
Circ Heart Fail. 2009 May;2(3):217-22
pubmed: 19808343
Immunol Cell Biol. 2018 Jul;96(6):666-674
pubmed: 29423939
Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L341-53
pubmed: 21131395
Pharmacotherapy. 2005 Sep;25(9):1271-6
pubmed: 16164401
J Cardiovasc Pharmacol Ther. 2017 Nov;22(6):538-545
pubmed: 28325070
Cell. 2001 Oct 5;107(1):1-3
pubmed: 11595178
Nat Rev Immunol. 2014 Aug;14(8):571-8
pubmed: 25033907
Diabetes. 2015 Feb;64(2):360-9
pubmed: 25338814
Immunity. 2019 Apr 16;50(4):1069-1083.e8
pubmed: 30926233
Cell Metab. 2019 Feb 5;29(2):443-456.e5
pubmed: 30595481
Clin Res Cardiol. 2017 Dec;106(12):939-946
pubmed: 28755285
Aging Cell. 2020 Feb;19(2):e13086
pubmed: 31823466
Hypertension. 2020 Jan;75(1):131-138
pubmed: 31786985
ESC Heart Fail. 2017 Aug;4(3):331-340
pubmed: 28772050
J Clin Invest. 2007 Jan;117(1):195-205
pubmed: 17200719
Circ Heart Fail. 2011 Jul;4(4):463-73
pubmed: 21558446
Nature. 2018 Apr 5;556(7699):113-117
pubmed: 29590092
Nat Cardiovasc Res. 2022 Mar;1(3):211-222
pubmed: 35755006
Transl Res. 2016 Jan;167(1):152-66
pubmed: 26241027
J Immunol. 2000 Dec 1;165(11):6037-46
pubmed: 11086035
Circ Res. 2009 Feb 13;104(3):403-11
pubmed: 19096023
J Clin Invest. 2016 Nov 1;126(11):4250-4261
pubmed: 27760048
Nat Commun. 2018 Jun 26;9(1):2432
pubmed: 29946151
Circ Res. 2016 Apr 1;118(7):1062-77
pubmed: 26926469
Circulation. 1989 Dec;80(6):1816-27
pubmed: 2598440
J Cell Mol Med. 2019 Nov;23(11):7505-7516
pubmed: 31557411
Cell Metab. 2020 Nov 3;32(5):710-725
pubmed: 33027638
Hypertens Res. 2022 Mar;45(3):401-413
pubmed: 34916664
Nat Commun. 2017 Nov 23;8(1):1747
pubmed: 29170511
Circ Heart Fail. 2020 Aug;13(8):e006414
pubmed: 32809874
Nat Rev Immunol. 2019 May;19(5):273-281
pubmed: 30705422
Immunity. 2016 Oct 18;45(4):817-830
pubmed: 27760338
Basic Res Cardiol. 2019 Aug 15;114(5):37
pubmed: 31418072
Nat Rev Cardiol. 2020 May;17(5):269-285
pubmed: 31969688
J Biol Chem. 2000 Aug 18;275(33):25130-8
pubmed: 10833514
Circulation. 2021 May 11;143(19):1912-1925
pubmed: 33715387
Cell Metab. 2018 Dec 4;28(6):922-934.e4
pubmed: 30174303
Nat Immunol. 2020 Mar;21(3):331-342
pubmed: 32066950
J Mol Cell Cardiol. 2019 Oct;135:134-148
pubmed: 31398346
Nat Commun. 2020 Aug 11;11(1):4011
pubmed: 32782249
Science. 2001 Apr 20;292(5516):464-8
pubmed: 11292862
Circulation. 2017 Jul 18;136(3):297-313
pubmed: 28432149
J Exp Med. 2011 Jul 4;208(7):1367-76
pubmed: 21708926
Circ Res. 2010 Jun 25;106(12):1861-9
pubmed: 20431058
Cell Rep. 2019 Nov 12;29(7):1878-1892.e7
pubmed: 31722204
J Mol Cell Cardiol. 2021 Sep;158:38-48
pubmed: 34023353
Circ Res. 2016 Sep 16;119(7):853-64
pubmed: 27444755
Eur Heart J. 2021 Nov 7;42(42):4309-4320
pubmed: 34343254
Cell. 2017 Oct 5;171(2):331-345.e22
pubmed: 28942921
Nat Med. 2013 Oct;19(10):1273-80
pubmed: 24037091
Phytomedicine. 2021 Oct;91:153633
pubmed: 34320423
Nat Metab. 2022 Mar;4(3):389-403
pubmed: 35347316
Cold Spring Harb Symp Quant Biol. 2011;76:225-33
pubmed: 22156303
PLoS One. 2014 Mar 04;9(3):e90639
pubmed: 24595332
Cell Metab. 2021 Feb 2;33(2):411-423.e4
pubmed: 33306983
Mol Cell Endocrinol. 2012 Sep 25;361(1-2):92-8
pubmed: 22480543
J Exp Med. 2016 Mar 7;213(3):337-54
pubmed: 26926996
Blood. 2022 Jan 13;139(2):281-286
pubmed: 34411229
Cell Rep. 2020 Feb 11;30(6):1898-1909.e4
pubmed: 32049019
Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2017-21
pubmed: 18250302
Small. 2021 Aug;17(32):e2101207
pubmed: 34216428
Cell. 2018 Jan 11;172(1-2):162-175.e14
pubmed: 29328911
Cell. 2020 Oct 1;183(1):94-109.e23
pubmed: 32937105
Eur Heart J. 2021 Mar 1;42(9):938-947
pubmed: 33338208
Nat Rev Cardiol. 2017 Oct;14(10):591-602
pubmed: 28492288
J Mol Cell Cardiol. 2020 Aug;145:1-13
pubmed: 32470468
Genes Dev. 2012 Jun 15;26(12):1326-38
pubmed: 22677546
J Clin Invest. 2015 Oct 26;125(12):4334-48
pubmed: 26517695
FASEB J. 2014 May;28(5):2202-13
pubmed: 24481967
Cardiovasc Res. 2020 Feb 1;116(2):317-328
pubmed: 31119285
Eur Heart J. 2014 Apr;35(16):1061-8
pubmed: 24375073
Cell Metab. 2006 Mar;3(3):187-97
pubmed: 16517406
J Immunol. 2015 Jun 1;194(11):5174-86
pubmed: 25917094
J Immunol. 2017 Jun 15;198(12):4738-4752
pubmed: 28500069
Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12825-30
pubmed: 12226479
Science. 2014 Sep 26;345(6204):1250684
pubmed: 25258083
J Am Coll Cardiol. 2010 Apr 13;55(15):1629-38
pubmed: 20378083
Circulation. 2010 Dec 14;122(24):2529-37
pubmed: 21126972
Front Immunol. 2022 Mar 15;13:817514
pubmed: 35371099
Am J Physiol Lung Cell Mol Physiol. 2007 Apr;292(4):L845-51
pubmed: 17122354
JACC Heart Fail. 2014 Apr;2(2):138-40
pubmed: 24720920
Circ Res. 2013 Sep 27;113(8):1004-12
pubmed: 23836795
Cell Rep. 2017 Mar 21;18(12):3005-3017
pubmed: 28329691
Nat Rev Immunol. 2021 Feb;21(2):101-115
pubmed: 32908299
Clin Chim Acta. 2010 Dec 14;411(23-24):1963-8
pubmed: 20713031
N Engl J Med. 2017 Sep 21;377(12):1119-1131
pubmed: 28845751
Cell Metab. 2016 Jul 12;24(1):158-66
pubmed: 27374498
Immunity. 2014 Jul 17;41(1):14-20
pubmed: 25035950
Science. 2006 Dec 15;314(5806):1792-5
pubmed: 17170310
Nature. 2020 Dec;588(7838):466-472
pubmed: 32971526
J Gen Physiol. 2019 Jan 7;151(1):42-52
pubmed: 30567709
Nat Commun. 2017 Mar 06;8:14680
pubmed: 28262700
J Mol Cell Cardiol. 2021 Aug;157:98-103
pubmed: 33971183
J Am Heart Assoc. 2015 Jun 02;4(6):e001993
pubmed: 26037082
Cardiovasc Res. 2018 Dec 1;114(14):1883-1893
pubmed: 29982418
J Immunol. 2011 Mar 15;186(6):3299-303
pubmed: 21317389
Nat Immunol. 2017 Sep;18(9):985-994
pubmed: 28714978
Elife. 2022 Sep 20;11:
pubmed: 36125130
Nat Immunol. 2014 Apr;15(4):323-32
pubmed: 24562310
Cell. 2021 Aug 5;184(16):4168-4185.e21
pubmed: 34216539
J Clin Invest. 2019 Aug 13;129(11):4922-4936
pubmed: 31408441
J Am Coll Cardiol. 2009 Dec 15;54(25):2435-46
pubmed: 20082935
N Engl J Med. 2011 Feb 17;364(7):656-65
pubmed: 21323543
Immunity. 2017 Nov 21;47(5):875-889.e10
pubmed: 29166588
J Exp Med. 2021 Sep 6;218(9):
pubmed: 34325467
Immunity. 2016 Jul 19;45(1):60-73
pubmed: 27396958
Proc Natl Acad Sci U S A. 2021 Jun 1;118(22):
pubmed: 34035164
J Immunol. 2014 Apr 15;192(8):3626-36
pubmed: 24616478
Circulation. 2020 Nov 3;142(18):1752-1769
pubmed: 32900241
JACC Heart Fail. 2016 Apr;4(4):312-24
pubmed: 26682792
J Exp Med. 2007 Oct 1;204(10):2449-60
pubmed: 17875676
Eur Heart J Case Rep. 2019 Sep 01;3(3):
pubmed: 31365055
JACC Basic Transl Sci. 2022 Mar 16;7(4):384-403
pubmed: 35540097
Ann Rheum Dis. 2016 Feb;75(2):439-48
pubmed: 25575725
Sci Rep. 2020 Mar 27;10(1):5555
pubmed: 32221369
Cell Metab. 2018 Mar 6;27(3):588-601.e4
pubmed: 29514067
Cardiovasc Res. 2023 May 2;119(3):772-785
pubmed: 35950218
Proc Natl Acad Sci U S A. 2013 May 7;110(19):7820-5
pubmed: 23610393
N Engl J Med. 2019 Feb 21;380(8):752-762
pubmed: 30415610
Front Cardiovasc Med. 2021 Sep 29;8:701745
pubmed: 34660710
Small. 2021 Apr;17(17):e2006992
pubmed: 33719217
Cell Metab. 2015 Jan 6;21(1):65-80
pubmed: 25565206
Hypertension. 2016 Jul;68(1):123-32
pubmed: 27217403
Am J Cardiol. 2009 Feb 1;103(3):333-7
pubmed: 19166685
Hypertension. 1999 Sep;34(3):478-83
pubmed: 10489397
Int J Cardiol. 2020 May 1;306:140-145
pubmed: 31711850
Circ Res. 2022 Apr 29;130(9):1289-1305
pubmed: 35400205
J Biol Chem. 2010 Apr 30;285(18):13630-7
pubmed: 20189995
PLoS One. 2015 May 26;10(5):e0124844
pubmed: 26010610
Eur Heart J. 2017 Jan 14;38(3):187-197
pubmed: 28158426
Circ Heart Fail. 2015 Jul;8(4):776-87
pubmed: 26022677
Eur Heart J. 2015 Aug 1;36(29):1923-34
pubmed: 25982896
J Clin Invest. 2015 Aug 3;125(8):3063-76
pubmed: 26168217
Nature. 2019 Apr;568(7752):351-356
pubmed: 30971818
Circulation. 2021 Sep 21;144(12):961-982
pubmed: 34255973
Am J Physiol Regul Integr Comp Physiol. 2008 Mar;294(3):R793-802
pubmed: 18199585
Hypertension. 2015 Nov;66(5):1023-33
pubmed: 26351030
Circ Res. 2020 Sep 11;127(7):877-892
pubmed: 32564710
Nature. 2018 Nov;563(7733):714-718
pubmed: 30464343
Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3887-9
pubmed: 16505364
Nat Immunol. 2019 Jan;20(1):29-39
pubmed: 30538339
J Exp Med. 2011 Mar 14;208(3):519-33
pubmed: 21282379
Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12228-32
pubmed: 20566875
JACC Cardiovasc Interv. 2011 Jan;4(1):14-23
pubmed: 21251624
Front Physiol. 2014 Dec 18;5:496
pubmed: 25566092
Sci Rep. 2016 Apr 12;6:24129
pubmed: 27067254
Sci Signal. 2015 Sep 29;8(396):ra97
pubmed: 26420908
Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21673-21684
pubmed: 31591231
ESC Heart Fail. 2021 Dec;8(6):5392-5402
pubmed: 34657379
J Exp Med. 2008 Mar 17;205(3):565-74
pubmed: 18283119
FASEB J. 2012 Dec;26(12):4855-63
pubmed: 22898923
JCI Insight. 2017 Jul 6;2(13):
pubmed: 28679951
Circulation. 2012 Apr 3;125(13):1652-63
pubmed: 22388323
Diabetologia. 2017 Oct;60(10):2033-2041
pubmed: 28660492
J Immunol. 2005 May 1;174(9):5390-7
pubmed: 15843537
Mol Metab. 2014 Jul 10;3(6):664-75
pubmed: 25161889
Cardiovasc Res. 2016 May 1;110(1):51-61
pubmed: 26825554
Am J Physiol Regul Integr Comp Physiol. 2013 Jul 15;305(2):R98-100
pubmed: 23657641
Am J Physiol Endocrinol Metab. 2008 Sep;295(3):E705-13
pubmed: 18647880
Circulation. 2021 Feb 23;143(8):821-836
pubmed: 33297741
JACC Heart Fail. 2020 Sep;8(9):712-724
pubmed: 32653448
Immunity. 2014 Jan 16;40(1):91-104
pubmed: 24439267
Biochim Biophys Acta Mol Basis Dis. 2022 Sep 1;1868(9):166427
pubmed: 35526742
Cell Metab. 2019 Jul 2;30(1):225
pubmed: 31269426
Redox Biol. 2022 Oct;56:102446
pubmed: 36057161
J Am Chem Soc. 2011 Oct 19;133(41):16386-9
pubmed: 21919507
Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):10436-41
pubmed: 27582470
J Biol Chem. 1994 Sep 23;269(38):23757-63
pubmed: 8089148
Hypertension. 2003 Jul;42(1):31-8
pubmed: 12771047
J Cell Biol. 1968 Sep;38(3):615-27
pubmed: 4874495
Front Immunol. 2017 May 29;8:609
pubmed: 28611773
Int Heart J. 2011;52(6):382-7
pubmed: 22188713
Cell Rep. 2019 Sep 17;28(12):3011-3021.e4
pubmed: 31533027
Nat Commun. 2021 Mar 5;12(1):1483
pubmed: 33674611
Nat Microbiol. 2016 Dec 19;2:16246
pubmed: 27991883
J Mol Cell Cardiol. 2022 Dec;173:25-29
pubmed: 36122767
Cell Immunol. 2014 May-Jun;289(1-2):42-8
pubmed: 24721110
Science. 2018 Apr 27;360(6387):449-453
pubmed: 29599194
J Am Heart Assoc. 2020 May 18;9(10):e014661
pubmed: 32378457
Blood. 2009 Oct 29;114(18):3803-12
pubmed: 19721009
J Am Coll Cardiol. 2013 Jul 23;62(4):263-71
pubmed: 23684677
Cell Metab. 2022 Oct 4;34(10):1499-1513.e8
pubmed: 36070756
JACC Basic Transl Sci. 2021 Aug 23;6(8):650-672
pubmed: 34466752
Immunity. 2015 Oct 20;43(4):817-29
pubmed: 26488817
Circ Res. 2020 Apr 24;126(9):1242-1259
pubmed: 32324501
J Card Fail. 2015 Feb;21(2):167-77
pubmed: 25459685
Diabetes. 2015 Apr;64(4):1420-30
pubmed: 25368099
Am J Respir Crit Care Med. 2017 Nov 15;196(10):1275-1286
pubmed: 28598224
Circ Res. 2008 Aug 29;103(5):467-76
pubmed: 18658050
Nat Metab. 2022 Apr;4(4):444-457
pubmed: 35361955
J Autoimmun. 2021 May;119:102611
pubmed: 33631650
Blood. 2006 Jun 1;107(11):4458-65
pubmed: 16449529
J Am Heart Assoc. 2016 Jul 29;5(8):
pubmed: 27473038
Sci Rep. 2019 Feb 28;9(1):3073
pubmed: 30816177
Cell. 2016 Oct 6;167(2):457-470.e13
pubmed: 27667687
Nature. 2011 Aug 21;477(7363):220-4
pubmed: 21857682