Multimodal Detection and Targeting of Biopsy-Proven Myocardial Inflammation in Genetic Cardiomyopathies: A Pilot Report.
cardiomyopathy
desmosomal gene variants
endomyocardial biopsy
genetics
immunosuppressive therapy
multimodal imaging
myocardial inflammation
Journal
JACC. Basic to translational science
ISSN: 2452-302X
Titre abrégé: JACC Basic Transl Sci
Pays: United States
ID NLM: 101677259
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
received:
12
12
2022
revised:
15
02
2023
accepted:
15
02
2023
medline:
7
8
2023
pubmed:
7
8
2023
entrez:
7
8
2023
Statut:
epublish
Résumé
The authors present a clinical report focused on the overlap between myocarditis and genetic cardiomyopathies of the dilated and arrhythmogenic spectrum. Our cohort was composed of 25 patients undergoing extensive baseline characterization and prospective reassessment by a dedicated multidisciplinary disease unit during a median follow-up of 69 months. We showed that the use of multimodal imaging allowed both discrimination of specific genotypes and identification of myocardial inflammation proven using endomyocardial biopsy. In addition, we showed that the use of immunomodulatory therapy was beneficial for most patients.
Identifiants
pubmed: 37547072
doi: 10.1016/j.jacbts.2023.02.018
pii: S2452-302X(23)00123-7
pmc: PMC10401291
doi:
Types de publication
Journal Article
Langues
eng
Pagination
755-765Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
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