Isolation and characterization of β-transducin repeat-containing protein ligands screened using a high-throughput screening system.
Chemical biology
F-box protein
Ubiquitin
Journal
Oncology research
ISSN: 1555-3906
Titre abrégé: Oncol Res
Pays: United States
ID NLM: 9208097
Informations de publication
Date de publication:
2023
2023
Historique:
received:
28
03
2023
accepted:
19
05
2023
medline:
8
8
2023
pubmed:
7
8
2023
entrez:
7
8
2023
Statut:
epublish
Résumé
β-transducin repeat-containing protein (β-TrCP) is an F-box protein subunit of the E3 Skp1-Cullin-F box (SCF) type ubiquitin-ligase complex, and provides the substrate specificity for the ligase. To find potent ligands of β-TrCP useful for the proteolysis targeting chimera (PROTAC) system using β-TrCP in the future, we developed a high-throughput screening system for small molecule β-TrCP ligands. We screened the chemical library utilizing the system and obtained several hit compounds. The effects of the hit compounds on
Identifiants
pubmed: 37547765
doi: 10.32604/or.2023.030240
pii: 30240
pmc: PMC10398414
doi:
Substances chimiques
beta-Transducin Repeat-Containing Proteins
0
SKP Cullin F-Box Protein Ligases
EC 2.3.2.27
Ligands
0
Cullin Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
645-654Informations de copyright
© 2023 Liu et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest to report regarding the present study.
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