Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFR
Humans
Antineoplastic Agents
/ chemistry
Cell Line, Tumor
Cell Proliferation
Drug Screening Assays, Antitumor
ErbB Receptors
/ metabolism
Erlotinib Hydrochloride
/ pharmacology
Lung Neoplasms
/ drug therapy
Molecular Docking Simulation
Mutation
Protein Kinase Inhibitors
/ chemistry
Quinolines
/ chemistry
Hexahydroquinoline
X-ray crystallography
anticancer
molecular docking
wild and mutant EGFR inhibition
Journal
Journal of enzyme inhibition and medicinal chemistry
ISSN: 1475-6374
Titre abrégé: J Enzyme Inhib Med Chem
Pays: England
ID NLM: 101150203
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
medline:
8
8
2023
pubmed:
7
8
2023
entrez:
7
8
2023
Statut:
ppublish
Résumé
Hexahydroquinoline (HHQ) scaffold was constructed and recruited for development of new series of anticancer agents. Thirty-two new compounds were synthesised where x-ray crystallography was performed to confirm enantiomerism. Thirteen compounds showed moderate to good activity against NCI 60 cancer cell lines, with GI % mean up to 74% for New 32 hexahydroquinoline (HHQ) analogues
Autres résumés
Type: plain-language-summary
(eng)
New 32 hexahydroquinoline (HHQ) analogues
Identifiants
pubmed: 37548154
doi: 10.1080/14756366.2023.2241674
pmc: PMC10408569
doi:
Substances chimiques
Antineoplastic Agents
0
EGFR protein, human
EC 2.7.10.1
ErbB Receptors
EC 2.7.10.1
Erlotinib Hydrochloride
DA87705X9K
Protein Kinase Inhibitors
0
Quinolines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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