Serum concentrations of BDNF in adolescents with metabolic syndrome: a case-control study between normal - BMI adolescents and adolescents with obesity.
Adolescents
BDNF
Brain derived neurotrophic factor
Metabolic syndrome
Obesity
Journal
European journal of pediatrics
ISSN: 1432-1076
Titre abrégé: Eur J Pediatr
Pays: Germany
ID NLM: 7603873
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
13
04
2023
accepted:
21
07
2023
revised:
05
07
2023
medline:
1
11
2023
pubmed:
7
8
2023
entrez:
7
8
2023
Statut:
ppublish
Résumé
Brain-Derived Neurotrophic Factor (BDNF) has been linked to various conditions of the cardiovascular and nervous systems. Scarce data exist about the concentrations of BDNF in children and adolescents in relation with obesity and metabolic syndrome (MetS). The aim of this study was to examine the serum BDNF concentrations in adolescents with metabolic syndrome and according to their body mass index (BMI) status. This was a case-control study, assessing BDNF concentrations between adolescents with MetS (with obesity vs. normal-BMI), in relation to sex, anthropometric, metabolic and endocrine parameters. Participants included male and female adolescents, whose anthropometric and metabolic panel, as well as serum BDNF concentrations were measured. A total of 59 adolescents (obesity: 29; normal-BMI: 30) were included in the study. Increased serum BDNF concentrations were observed in MetS adolescents with obesity when compared with normal-BMI adolescents (p < 0.001). Males exhibited higher concentrations of BDNF than females (p = 0.045). The sample was further divided into four categories by sex and BMI status, with normal-BMI females exhibiting significantly lower BDNF concentrations than females and males with obesity(p = 0.005). In the entire study sample, serum BDNF concentrations correlated positively with BMI z-scores, however, this statistical significance was preserved only in the females of the sample. No statistical difference was observed between males of different BMI z-scores categories. Conclusion: Obesity appeared as a major factor for increased serum BDNF concentrations in adolescents with MetS (vs. normal-BMI), with a higher impact on BDNF concentrations in females than males. What is Known: • The brain-derived neurotrophic factor (BDNF) is involved in metabolic syndrome in adults but data in adolescents are scarce. What is New: • Obesity (vs. normal BMI) was a major factor for increased serum BDNF in adolescents with metabolic syndrome. • Obesity had a higher impact on BDNF concentrations in females than males with metabolic syndrome.
Identifiants
pubmed: 37548699
doi: 10.1007/s00431-023-05129-3
pii: 10.1007/s00431-023-05129-3
pmc: PMC10587278
doi:
Substances chimiques
Brain-Derived Neurotrophic Factor
0
BDNF protein, human
7171WSG8A2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4595-4603Informations de copyright
© 2023. The Author(s).
Références
Marosi K, Mattson MP (2014) BDNF mediates adaptive brain and body responses to energetic challenges. Trends Endocrinol Metab 25(2):89–98
doi: 10.1016/j.tem.2013.10.006
pubmed: 24361004
Leal G, Bramham CR, Duarte CB (2017) BDNF and Hippocampal Synaptic Plasticity. Vitam Horm 104:153–195
doi: 10.1016/bs.vh.2016.10.004
pubmed: 28215294
Yoshimura R, Sugita-Ikenouchi A, Hori H et al (2010) A close correlation between plasma and serum levels of brain-derived neurotrophic factor (BDNF) in healthy volunteers. Int J Psychiatry Clin Pract 14(3):220–222
doi: 10.3109/13651501003748560
pubmed: 24917323
Mori Y, Tsuji M, Oguchi T et al (2021) Serum BDNF as a Potential Biomarker of Alzheimer’s Disease: Verification Through Assessment of Serum, Cerebrospinal Fluid, and Medial Temporal Lobe Atrophy. Front Neurol 12:653267
doi: 10.3389/fneur.2021.653267
pubmed: 33967943
pmcid: 8102980
Emon MPZ, Das R, Nishuty NL, Shalahuddin Qusar MMA, Bhuiyan MA, Islam MR (2020) Reduced serum BDNF levels are associated with the increased risk for developing MDD: a case-control study with or without antidepressant therapy. BMC Res Notes 13(1):83
doi: 10.1186/s13104-020-04952-3
pubmed: 32085720
pmcid: 7035767
Azoulay D, Urshansky N, Karni A (2008) Low and dysregulated BDNF secretion from immune cells of MS patients is related to reduced neuroprotection. J Neuroimmunol 195(1–2):186–193
doi: 10.1016/j.jneuroim.2008.01.010
pubmed: 18329726
Huang Y, Yun W, Zhang M, Luo W, Zhou X (2018) Serum concentration and clinical significance of brain-derived neurotrophic factor in patients with Parkinson’s disease or essential tremor. J Int Med Res 46(4):1477–1485
doi: 10.1177/0300060517748843
pubmed: 29350074
pmcid: 6091839
Hashimoto K, Iwata Y, Nakamura K et al (2006) Reduced serum levels of brain-derived neurotrophic factor in adult male patients with autism. Prog Neuropsychopharmacol Biol Psychiatry 30(8):1529–1531
doi: 10.1016/j.pnpbp.2006.06.018
pubmed: 16876305
Ruiz-González D, Hernández-Martínez A, Valenzuela PL, Morales JS, Soriano-Maldonado A (2021) Effects of physical exercise on plasma brain-derived neurotrophic factor in neurodegenerative disorders: a systematic review and meta-analysis of randomized controlled trials. Neurosci Biobehav Rev 128:394–405
doi: 10.1016/j.neubiorev.2021.05.025
pubmed: 34087277
Pugazhenthi S, Qin L, Reddy PH (2017) Common neurodegenerative pathways in obesity, diabetes, and Alzheimer’s disease. Biochim Biophys Acta 1863(5):1037–1045
doi: 10.1016/j.bbadis.2016.04.017
Motamedi S, Karimi I, Jafari F (2017) The interrelationship of metabolic syndrome and neurodegenerative diseases with focus on brain-derived neurotrophic factor (BDNF): Kill two birds with one stone. Metab Brain Dis 32(3):651–665
doi: 10.1007/s11011-017-9997-0
pubmed: 28361262
Roh H-T, So W-Y (2017) The effects of aerobic exercise training on oxidant-antioxidant balance, neurotrophic factor levels, and blood-brain barrier function in obese and non-obese men. J Sport Health Sci 6(4):447–453
doi: 10.1016/j.jshs.2016.07.006
pubmed: 30356625
Krabbe KS, Nielsen AR, Krogh-Madsen R et al (2007) Brain-derived neurotrophic factor (BDNF) and type 2 diabetes. Diabetologia 50(2):431–438
doi: 10.1007/s00125-006-0537-4
pubmed: 17151862
Singh RB, Takahashi T, Tokunaga M et al (2014) Effect of brain derived neurotrophic factor, in relation to diet and lifestyle factors, for prevention of neuropsychiatric and vascular diseases and diabetes. Open Nutraceuticals J 7(1)
Barbosa AG, Pratesi R, Paz GSC et al (2020) Assessment of BDNF serum levels as a diagnostic marker in children with autism spectrum disorder. Sci Rep 10(1):17348
doi: 10.1038/s41598-020-74239-x
pubmed: 33060610
pmcid: 7566481
Han JC, Muehlbauer MJ, Cui HN, Newgard CB, Haqq AM (2010) Lower brain-derived neurotrophic factor in patients with prader-willi syndrome compared to obese and lean control subjects. J Clin Endocrinol Metab 95(7):3532–3536
doi: 10.1210/jc.2010-0127
pubmed: 20427492
pmcid: 2928902
Margoni D, Michalakakou K, Angeli E et al (2018) Serum brain-derived neurotrophic factor in children with coeliac disease. Eur J Clin Invest 48(5):e12916
doi: 10.1111/eci.12916
pubmed: 29469186
Sandrini L, Di Minno A, Amadio P, Ieraci A, Tremoli E, Barbieri SS (2018) Association between Obesity and Circulating Brain-Derived Neurotrophic Factor (BDNF) Levels: Systematic Review of Literature and Meta-Analysis. Int J Mol Sci 19(8)
Silva SP, Beserra-Filho JIA, Kubota MC et al (2021) Palatable high-fat diet intake influences mnemonic and emotional aspects in female rats in an estrous cycle-dependent manner. Metabolic Brain Dis 36(7):1717–1727
doi: 10.1007/s11011-021-00812-6
Zimmet P, Alberti KG, Kaufman F et al (2007) The metabolic syndrome in children and adolescents - an IDF consensus report. Pediatr Diabetes 8(5):299–306
doi: 10.1111/j.1399-5448.2007.00271.x
pubmed: 17850473
Bacopoulou F, Efthymiou V, Landis G, Rentoumis A, Chrousos GP (2015) Waist circumference, waist-to-hip ratio and waist-to-height ratio reference percentiles for abdominal obesity among Greek adolescents. BMC Pediatr 15:50
doi: 10.1186/s12887-015-0366-z
pubmed: 25935716
pmcid: 4446827
De Sanctis V, Soliman A, Daar S, Tzoulis P, Di Maio S, Kattamis C (2022) Oral glucose tolerance test: Etaow to maximize its diagnostic value in children and adolescents. Acta Biomed 93(5):e2022318
pubmed: 36300215
pmcid: 9686143
Bartoli E, Fra GP, Carnevale Schianca GP (2011) The oral glucose tolerance test (OGTT) revisited. Eur J Intern Med 22(1):8–12
doi: 10.1016/j.ejim.2010.07.008
pubmed: 21238885
Cole TJ, Bellizzi MC, Flegal KM, Dietz WH (2000) Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ (Clinical research ed) 320(7244):1240–1243
doi: 10.1136/bmj.320.7244.1240
pubmed: 10797032
Pruessner JC, Kirschbaum C, Meinlschmid G, Hellhammer DH (2003) Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology 28(7):916–931
doi: 10.1016/S0306-4530(02)00108-7
pubmed: 12892658
Julious SA (2005) Sample size of 12 per group rule of thumb for a pilot study. Pharm Stat 4(4):287–291
doi: 10.1002/pst.185
Iughetti L, Casarosa E, Predieri B, Patianna V, Luisi S (2011) Plasma brain-derived neurotrophic factor concentrations in children and adolescents. Neuropeptides 45(3):205–211
doi: 10.1016/j.npep.2011.02.002
pubmed: 21420165
Lommatzsch M, Zingler D, Schuhbaeck K et al (2005) The impact of age, weight and gender on BDNF levels in human platelets and plasma. Neurobiol Aging 26(1):115–123
doi: 10.1016/j.neurobiolaging.2004.03.002
pubmed: 15585351
Lee IT, Wang JS, Fu CP, Lin SY, Sheu WH (2016) Relationship between body weight and the increment in serum brain-derived neurotrophic factor after oral glucose challenge in men with obesity and metabolic syndrome: A prospective study. Medicine 95(43):e5260
doi: 10.1097/MD.0000000000005260
pubmed: 27787389
pmcid: 5089118
Celik Guzel E, Bakkal E, Guzel S et al (2014) Can low brain-derived neurotrophic factor levels be a marker of the presence of depression in obese women? Neuropsychiatr Dis Treat 10:2079–2086
doi: 10.2147/NDT.S72087
pubmed: 25395856
pmcid: 4226451
Gajewska E, Sobieska M, Łojko D, Wieczorowska-Tobis K, Suwalska A (2014) Obesity itself does not influence BDNF serum levels in adults. Eur Rev Med Pharmacol Sci 18(21):3246–3250
pubmed: 25487935
Flores-Dorantes MT, Díaz-López YE, Gutiérrez-Aguilar R (2020) Environment and Gene Association With Obesity and Their Impact on Neurodegenerative and Neurodevelopmental Diseases. Front Neurosci 14:863
doi: 10.3389/fnins.2020.00863
pubmed: 32982666
pmcid: 7483585
Podyma B, Parekh K, Güler AD, Deppmann CD (2021) Metabolic homeostasis via BDNF and its receptors. Trends Endocrinol Metab 32(7):488–499
doi: 10.1016/j.tem.2021.04.005
pubmed: 33958275
pmcid: 8192464
Li H, Liu L, Tang Y et al (2014) Sex-specific association of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and plasma BDNF with attention-deficit/hyperactivity disorder in a drug-naïve Han Chinese sample. Psychiatry Res 217(3):191–197
doi: 10.1016/j.psychres.2014.03.011
pubmed: 24713358
Bilgiç A, Çelikkol Sadıç Ç, Kılınç İ, Akça ÖF (2020) Exploring the association between depression, suicidality and serum neurotrophin levels in adolescents. Int J Psychiatry Clin Pract 24(2):143–150
doi: 10.1080/13651501.2020.1723643
pubmed: 32027188
Corominas-Roso M, Ramos-Quiroga JA, Ribases M et al (2013) Decreased serum levels of brain-derived neurotrophic factor in adults with attention-deficit hyperactivity disorder. Int J Neuropsychopharmacol 16(6):1267–1275
doi: 10.1017/S1461145712001629
pubmed: 23363778
Russo F, Chimienti G, Clemente C, Ferreri C, Orlando A, Riezzo G (2017) A possible role for ghrelin, leptin, brain-derived neurotrophic factor and docosahexaenoic acid in reducing the quality of life of coeliac disease patients following a gluten-free diet. Eur J Nutr 56(2):807–818
doi: 10.1007/s00394-015-1128-2
pubmed: 26687809
Scharfman HE, MacLusky NJ (2006) Estrogen and brain-derived neurotrophic factor (BDNF) in hippocampus: complexity of steroid hormone-growth factor interactions in the adult CNS. Front Neuroendocrinol 27(4):415–435
doi: 10.1016/j.yfrne.2006.09.004
pubmed: 17055560
pmcid: 1778460
Bacopoulou F, Efthymiou V, Palaiologos G et al (2019) Telemedicine screening adolescent metabolic syndrome in Greek schools. Eur J Clin Invest 49(4):e13075
doi: 10.1111/eci.13075
pubmed: 30701542
Tenny S, Kerndt CC, Hoffman MR (2023) Case Control Studies. StatPearls [Internet]. StatPearls Publishing, Treasure Island (FL)
Huang T, Gejl AK, Tarp J, Andersen LB, Peijs L, Bugge A (2017) Cross-sectional associations of objectively measured physical activity with brain-derived neurotrophic factor in adolescents. Physiol Behav 171:87–91
doi: 10.1016/j.physbeh.2016.12.026
pubmed: 28027935
Glud M, Christiansen T, Larsen LH, Richelsen B, Bruun JM (2019) Changes in Circulating BDNF in relation to Sex, Diet, and Exercise: A 12-Week Randomized Controlled Study in Overweight and Obese Participants. J Obes 2019:4537274
doi: 10.1155/2019/4537274
pubmed: 31781387
pmcid: 6875316