Matrix metalloproteinases are associated with brain atrophy in cognitively unimpaired individuals.

Humans Matrix Metalloproteinase 2 / cerebrospinal fluid Matrix Metalloproteinase 3 Alzheimer Disease / pathology Atrophy / pathology Brain / diagnostic imaging Biomarkers / cerebrospinal fluid
Cerebrospinal fluid Cognitively unimpaired older adults Magnetic resonance imaging Matrix metalloproteinases Tissue inhibitor of metalloproteinases

Journal

Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437

Informations de publication

Date de publication:
Nov 2023
Historique:
received: 19 12 2022
revised: 28 04 2023
accepted: 20 05 2023
medline: 23 10 2023
pubmed: 7 8 2023
entrez: 7 8 2023
Statut: ppublish

Résumé

Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) have been linked to age-related neurodegeneration and Alzheimer's disease (AD), but their role in normal aging is poorly understood. We used linear mixed models to determine if baseline or rate of yearly change in cerebrospinal fluid (CSF) levels of MMP-2; MMP-3; MMP-10; TIMP-123 (composite of TIMP-1, TIMP-2, and TIMP-3); or TIMP-4 predicted changes in bilateral entorhinal cortex thickness, hippocampal volume, or lateral ventricle volume in cognitively unimpaired individuals. We also assessed effects on the CSF AD biomarkers amyloid-β

Identifiants

DOI: 10.1016/j.neurobiolaging.2023.05.012 PMID: 37549446
pubmed: 37549446
pii: S0197-4580(23)00104-5
doi: 10.1016/j.neurobiolaging.2023.05.012
pii:
doi:

Substances chimiques

Matrix Metalloproteinase 2 EC 3.4.24.24
Matrix Metalloproteinase 3 EC 3.4.24.17
Biomarkers 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

11-23

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest We declare that this work is original, has not been published before, and is not currently being considered for publication elsewhere. The manuscript is not currently under consideration for publication by any other journal, nor has it been previously published. The study was conducted in accordance with the Declaration of Helsinki and approved by the Regional Committee for Ethics in Medical Research in Norway. All co-authors agree with the content of this work.

Auteurs

Mari Aksnes (M)

Department of Geriatric Medicine, University of Oslo, Oslo, Norway. Electronic address: mari.aksnes@medisin.uio.no.

Elettra Capogna (E)

Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.

Didac Vidal-Piñeiro (D)

Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.

Farrukh Abbas Chaudhry (FA)

Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

Marius Myrstad (M)

Department of Internal Medicine, Bærum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway; Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway.

Ane-Victoria Idland (AV)

Oslo Delirium Research Group, Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.

Nathalie Bodd Halaas (NB)

Oslo Delirium Research Group, Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.

Shams Dakhil (S)

Oslo Delirium Research Group, Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Kaj Blennow (K)

Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.

Henrik Zetterberg (H)

Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK; UK Dementia Research Institute at UCL, London, UK; Hong Center for Neurodegenerative Diseases, Hong Kong, China; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.

Kristine Beate Walhovd (KB)

Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway; Computational Radiology and Artificial Intelligence, Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.

Leiv Otto Watne (LO)

Department of Geriatric Medicine, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway.

Anders Martin Fjell (AM)

Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway; Computational Radiology and Artificial Intelligence, Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Matrix metalloproteinases are associated with...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Secreted matrix metalloproteinases › Matrix metalloproteinase 2 › Matrix metalloproteinases are associated with...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Secreted matrix metalloproteinases › Matrix metalloproteinase 3 › Matrix metalloproteinases are associated with...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Matrix metalloproteinases are associated with...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Atrophie › Matrix metalloproteinases are associated with...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Matrix metalloproteinases are associated with...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Matrix metalloproteinases are associated with...