Difficulties in translating in vitro hazards of local acute irritants to relevant human risk: Learnings from Captan and Folpet.
Journal
Regulatory toxicology and pharmacology : RTP
ISSN: 1096-0295
Titre abrégé: Regul Toxicol Pharmacol
Pays: Netherlands
ID NLM: 8214983
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
29
03
2023
revised:
31
07
2023
accepted:
31
07
2023
medline:
1
9
2023
pubmed:
8
8
2023
entrez:
7
8
2023
Statut:
ppublish
Résumé
In order to assess the regulatory value of New Approach Methodologies (NAMs), authors should provide their opinion on the physiological and exposure relevance of observed in vitro effects for correlation with predicted in vivo effects. Further, peer-reviewers should be encouraged to request such information during review. This is critical to scientifically transition to animal-free, reliable, robust and -- most importantly -- relevant regulatory toxicology and risk assessment approaches. Recently published studies using NAMs for the fungicides Captan and Folpet illustrate the difficulties and limitations of applying NAMs to adequately assess the toxicological relevance of these substances.
Identifiants
pubmed: 37549825
pii: S0273-2300(23)00135-6
doi: 10.1016/j.yrtph.2023.105467
pii:
doi:
Substances chimiques
Captan
EOL5G26Q9F
folpet
X5NFK36917
Irritants
0
Phthalimides
0
Fungicides, Industrial
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105467Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: FMK works as a regulatory toxicologist for ADAMA, which registers, produces, and markets Captan, Folpet and their products.