DELE1 oligomerization promotes integrated stress response activation.
Journal
Nature structural & molecular biology
ISSN: 1545-9985
Titre abrégé: Nat Struct Mol Biol
Pays: United States
ID NLM: 101186374
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
19
10
2022
accepted:
11
07
2023
medline:
14
9
2023
pubmed:
8
8
2023
entrez:
7
8
2023
Statut:
ppublish
Résumé
Mitochondria are dynamic organelles that continually respond to cellular stress. Recent studies have demonstrated that mitochondrial stress is relayed from mitochondria to the cytosol by the release of a proteolytic fragment of DELE1 that binds to the eIF2α kinase HRI to initiate integrated stress response (ISR) signaling. We report the cryo-electron microscopy structure of the C-terminal cleavage product of human DELE1, which assembles into a high-order oligomer. The oligomer consists of eight DELE1 monomers that assemble with D
Identifiants
pubmed: 37550454
doi: 10.1038/s41594-023-01061-0
pii: 10.1038/s41594-023-01061-0
pmc: PMC10528447
mid: NIHMS1926443
doi:
Substances chimiques
eIF-2 Kinase
EC 2.7.11.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1295-1302Subventions
Organisme : NIH HHS
ID : S10 OD032467
Pays : United States
Organisme : NIH HHS
ID : S10 OD021634
Pays : United States
Organisme : NINDS NIH HHS
ID : RF1 NS125674
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS095892
Pays : United States
Organisme : NIA NIH HHS
ID : F31 AG071162
Pays : United States
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.
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