Delayed Detection of a 5-Aminolevulinic Acid
Aminolevulinic acid
Brain Neoplasms
Breast
Carcinoma, ductal
Journal
Brain tumor research and treatment
ISSN: 2288-2405
Titre abrégé: Brain Tumor Res Treat
Pays: Korea (South)
ID NLM: 101627407
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
received:
07
04
2023
revised:
31
05
2023
accepted:
26
06
2023
medline:
8
8
2023
pubmed:
8
8
2023
entrez:
7
8
2023
Statut:
ppublish
Résumé
A 44-year-old female patient who had been diagnosed with breast cancer visited our oncology department. She had developed right-side weakness and mild dysarthria, and MRI revealed a 4-cm cystic-enhancing lesion in her left frontal lobe. Her surgery was postponed 48 hours after receiving 5-aminolevulinic acid (5-ALA), because a problem with thyroid function that had not been noticed before was discovered. The main lesion was enhanced on navigation and appeared to be a gross tumor; its 5-ALA uptake was very high. Specimens obtained from this location were histologically confirmed to contain tumor cells. The operation was completed, and removal of all enhancing lesions was confirmed by MRI within 24 hours postoperatively. The pathology report confirmed metastatic ductal carcinoma. The clinical efficacy of 5-ALA was confirmed even 48 hours after administration into a metastatic brain tumor from breast cancer.
Identifiants
pubmed: 37550822
pii: 11.216
doi: 10.14791/btrt.2023.0014
pmc: PMC10409620
doi:
Types de publication
Case Reports
Langues
eng
Pagination
216-218Informations de copyright
Copyright © 2023 The Korean Brain Tumor Society, The Korean Society for Neuro-Oncology, and The Korean Society for Pediatric Neuro-Oncology.
Déclaration de conflit d'intérêts
The authors have no potential conflicts of interest to disclose.
Références
Brain Tumor Res Treat. 2019 Oct;7(2):105-111
pubmed: 31686441
Neurosurgery. 1998 Mar;42(3):518-25; discussion 525-6
pubmed: 9526986
J Neurosurg. 2009 Jan;110(1):156-62
pubmed: 18847342
J Neurooncol. 2022 Dec;160(3):669-675
pubmed: 36370294
Neurosurgery. 2008 Mar;62(3):564-76; discussion 564-76
pubmed: 18425006
Neurosurg Rev. 2019 Dec;42(4):799-809
pubmed: 30519770
J Clin Oncol. 2014 Mar 10;32(8):774-82
pubmed: 24516010
Lancet Oncol. 2006 May;7(5):392-401
pubmed: 16648043
Neuro Oncol. 2022 Nov 2;24(Suppl 6):S52-S61
pubmed: 36322101
Neurosurgery. 2019 Oct 1;85(4):E739-E746
pubmed: 31058995
Brain Tumor Res Treat. 2019 Oct;7(2):98-104
pubmed: 31686440
J Neurochem. 2000 Jul;75(1):321-8
pubmed: 10854277
PLoS One. 2013 May 28;8(5):e63682
pubmed: 23723993
J Neurosurg. 2000 Dec;93(6):1003-13
pubmed: 11117842
J Neurosurg. 2011 Mar;114(3):613-23
pubmed: 20397896