Cytogenetic characteristics of and prognosis for acute myeloid leukemia in 107 children.
acute
childhood leukemias
cytogenetic analysis
karyotype
leukemia
myeloid
prognosis
Journal
Asian biomedicine : research, reviews and news
ISSN: 1875-855X
Titre abrégé: Asian Biomed (Res Rev News)
Pays: Thailand
ID NLM: 101465147
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
medline:
30
4
2021
pubmed:
30
4
2021
entrez:
8
8
2023
Statut:
epublish
Résumé
Patients diagnosed with acute myeloid leukemia (AML) in childhood have a poor prognosis. A better understanding of prognostic factors will assist patients and clinicians in making difficult treatment decisions. To understand further the cytogenetic characteristics of and reassess the prognostic value of cytogenetic abnormalities in childhood AML. Conventional karyotypes of 107 children with AML were analyzed retrospectively. The cases were divided into 4 groups based on genetic rearrangements; namely patients with: t(15;17)/ All French-American-British (FAB) subtypes of AML were detected in 107 patients. We successfully cultured 81 of 107 bone marrow specimens, of which 60 cases had abnormal karyotypes. The most common abnormal karyotypes were t(8;21) (17/81 cases), followed by t(15;17) (13/81 cases), -X/Y (10/81 cases). There were no significant differences ( Chromosomal abnormalities may provide important prognostic factors for AML in children and be helpful for risk stratification and individual treatment.
Sections du résumé
Background
UNASSIGNED
Patients diagnosed with acute myeloid leukemia (AML) in childhood have a poor prognosis. A better understanding of prognostic factors will assist patients and clinicians in making difficult treatment decisions.
Objectives
UNASSIGNED
To understand further the cytogenetic characteristics of and reassess the prognostic value of cytogenetic abnormalities in childhood AML.
Methods
UNASSIGNED
Conventional karyotypes of 107 children with AML were analyzed retrospectively. The cases were divided into 4 groups based on genetic rearrangements; namely patients with: t(15;17)/
Results
UNASSIGNED
All French-American-British (FAB) subtypes of AML were detected in 107 patients. We successfully cultured 81 of 107 bone marrow specimens, of which 60 cases had abnormal karyotypes. The most common abnormal karyotypes were t(8;21) (17/81 cases), followed by t(15;17) (13/81 cases), -X/Y (10/81 cases). There were no significant differences (
Conclusions
UNASSIGNED
Chromosomal abnormalities may provide important prognostic factors for AML in children and be helpful for risk stratification and individual treatment.
Identifiants
pubmed: 37551405
doi: 10.2478/abm-2021-0010
pii: abm-2021-0010
pmc: PMC10388776
doi:
Types de publication
Journal Article
Langues
eng
Pagination
79-89Informations de copyright
© 2021 Wanzi Chen et al., published by Sciendo.
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