Gene therapy of adeno-associated virus (AAV) vectors in preclinical models of ischemic stroke.
adeno-associated virus
gene therapy
ischemic stroke
Journal
CNS neuroscience & therapeutics
ISSN: 1755-5949
Titre abrégé: CNS Neurosci Ther
Pays: England
ID NLM: 101473265
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
revised:
15
07
2023
received:
09
06
2023
accepted:
27
07
2023
medline:
27
11
2023
pubmed:
8
8
2023
entrez:
8
8
2023
Statut:
ppublish
Résumé
Stroke has been associated with devastating clinical outcomes, with current treatment strategies proving largely ineffective. Therefore, there is a need to explore alternative treatment options for addressing post-stroke functional deficits. Gene therapy utilizing adeno-associated viruses (AAVs) as a critical gene vector delivering genes to the central nervous system (CNS) gene delivery has emerged as a promising approach for treating various CNS diseases. This review aims to provide an overview of the biological characteristics of AAV vectors and the therapeutic advancements observed in preclinical models of ischemic stroke. The study further investigates the potential of manipulating AAV vectors in preclinical applications, emphasizing the challenges and prospects in the selection of viral vectors, drug delivery strategies, immune reactions, and clinical translation.
Identifiants
pubmed: 37551863
doi: 10.1111/cns.14392
pmc: PMC10651967
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3725-3740Subventions
Organisme : Academic Promotion Program of Shandong First Medical University & Shandong Academy of Medical Sciences
ID : 2019QL016
Organisme : Natural Science Foundation of Shandong Province
ID : ZR2022MH246
Organisme : Natural Science Foundation of Shandong Province
ID : ZR2021QH160
Organisme : National Natural Science Foundation of China
ID : 81871855
Organisme : Youth Innovation Team of Shandong Universities
ID : 2021KJ053
Informations de copyright
© 2023 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd.
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