HLA-B*53:01 Is a Significant Risk Factor of Liver Injury due to Phenytoin and Other Antiepileptic Drugs in African Americans.
Journal
The American journal of gastroenterology
ISSN: 1572-0241
Titre abrégé: Am J Gastroenterol
Pays: United States
ID NLM: 0421030
Informations de publication
Date de publication:
02 Oct 2023
02 Oct 2023
Historique:
received:
02
05
2023
accepted:
14
07
2023
pubmed:
8
8
2023
medline:
8
8
2023
entrez:
8
8
2023
Statut:
aheadofprint
Résumé
To investigate human leukocyte antigen alleles associated with liver injury due to antiepileptic drugs (AEDs) in African Americans (AA). In this study, 21 AA with AED drug-induced liver injury (DILI), 176 AA with DILI due to non-AEDs, and 5816 AA population controls were included. HLA-B*53:01 was significantly associated with aromatic AED-DILI (odds ratio: 4.52, 95% confidence interval: 2.42-8.44, P = 1.46 × 10 -5 ). Phenytoin DILI showed the strongest association with HLA-B*53:01 (odds ratio: 9.17; 95% confidence interval: 3.61-23.28, P = 1.1 × 10 -5 ). The HLA-B*53:01 allele was carried by 8 of 9 AA phenytoin DILI cases. HLA-B*53:01 is a significant risk factor of liver injury due to antiepileptics, particularly phenytoin, in AA.
Identifiants
pubmed: 37552102
doi: 10.14309/ajg.0000000000002454
pii: 00000434-990000000-00833
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : U01-DK065176
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24-DK065176
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01-DK065211
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01-DK065201
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01-DK065184
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01-DK065193
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01-DK065238
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01-DK083023
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01-DK083020
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01-DK082992
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01-DK083027
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01-DK100928
Pays : United States
Informations de copyright
Copyright © 2023 by The American College of Gastroenterology.
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