Drug-induced hyperinsulinemic hypoglycemia: An update on pathophysiology and treatment.
Drug-induced hyperinsulinism
Hyperinsulinism
Hypoglycemia
Review
Journal
Reviews in endocrine & metabolic disorders
ISSN: 1573-2606
Titre abrégé: Rev Endocr Metab Disord
Pays: Germany
ID NLM: 100940588
Informations de publication
Date de publication:
12 2023
12 2023
Historique:
accepted:
28
07
2023
medline:
6
12
2023
pubmed:
8
8
2023
entrez:
8
8
2023
Statut:
ppublish
Résumé
The initial step for the differential diagnosis of hypoglycemia is to determine whether it is hyperinsulinemic or non hyperinsulinemic. Existing literature discusses drug-related hypoglycemia, but it misses a focus on drug-induced hyperinsulinemic hypoglycemia (DHH). Here we reviewed the association existing between drugs and hyperinsulinemic hypoglycemia. We primarily selected on the main electronic databases (MEDLINE, EMBASE, Web of Science, and SCOPUS) the reviews on drug-induced hypoglycemia. Among the drugs listed in the reviews, we selected the ones linked to an increase in insulin secretion. For the drugs missing a clear association with insulin secretion, we investigated the putative mechanism underlying hypoglycemia referring to the original papers. Our review provides a list of the most common agents associated with hyperinsulinemic hypoglycemia (HH), in order to facilitate both the recognition and the prevention of DHH. We also collected data about the responsiveness of DHH to diazoxide or octreotide.
Identifiants
pubmed: 37552352
doi: 10.1007/s11154-023-09828-y
pii: 10.1007/s11154-023-09828-y
doi:
Substances chimiques
Diazoxide
O5CB12L4FN
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1031-1044Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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