Prothrombin consumption as an indicator of hemorrhagic phenotype in mild platelet function disorders.
bleeding score
blood platelet disorders
flow cytometry
light transmission aggregometry
platelet function test
prothrombin consumption
Journal
European journal of haematology
ISSN: 1600-0609
Titre abrégé: Eur J Haematol
Pays: England
ID NLM: 8703985
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
revised:
28
07
2023
received:
17
05
2023
accepted:
31
07
2023
pubmed:
9
8
2023
medline:
9
8
2023
entrez:
9
8
2023
Statut:
ppublish
Résumé
The bleeding risk of patients with mild platelet function disorders is difficult to assess and their phenotype remains ill-explored. This study was designed to establish a comprehensive biological phenotype of patients with mild platelet function disorders. Twenty patients were included with persistent abnormal light transmission aggregometry (LTA). The ISTH bleeding assessment tool (ISTH-BAT) was assessed to identify laboratory analyses associated with an abnormal hemorrhagic score. The majority of patients had defects that might affect Gαi protein signaling pathways or minor abnormalities. No LTA nor flow cytometry parameters were associated with an above-normal hemorrhagic score. However, prothrombin consumption, which corresponds to the ratio of serum residual factor II to plasma residual factor II, was significantly higher (p = .006) in the abnormal ISTH-BAT group (mean = 14%, SD = 6) compared with the normal ISTH-BAT group (mean = 8%, SD 4). Prothrombin consumption was significantly associated with ISTH-BAT score (r = .5287, IC 95% 0.0986-0.7924, p = .0165). In this group of patients, there was an association between a pathological bleeding score and increased prothrombin consumption. This test could be used as an additional indicator of platelet function abnormality liable to be related to bleeding risk.
Sections du résumé
BACKGROUND
BACKGROUND
The bleeding risk of patients with mild platelet function disorders is difficult to assess and their phenotype remains ill-explored.
AIM
OBJECTIVE
This study was designed to establish a comprehensive biological phenotype of patients with mild platelet function disorders.
METHODS
METHODS
Twenty patients were included with persistent abnormal light transmission aggregometry (LTA). The ISTH bleeding assessment tool (ISTH-BAT) was assessed to identify laboratory analyses associated with an abnormal hemorrhagic score.
RESULTS
RESULTS
The majority of patients had defects that might affect Gαi protein signaling pathways or minor abnormalities. No LTA nor flow cytometry parameters were associated with an above-normal hemorrhagic score. However, prothrombin consumption, which corresponds to the ratio of serum residual factor II to plasma residual factor II, was significantly higher (p = .006) in the abnormal ISTH-BAT group (mean = 14%, SD = 6) compared with the normal ISTH-BAT group (mean = 8%, SD 4). Prothrombin consumption was significantly associated with ISTH-BAT score (r = .5287, IC 95% 0.0986-0.7924, p = .0165).
CONCLUSION
CONCLUSIONS
In this group of patients, there was an association between a pathological bleeding score and increased prothrombin consumption. This test could be used as an additional indicator of platelet function abnormality liable to be related to bleeding risk.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
787-795Informations de copyright
© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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