Associations of mTBI and post-traumatic stress to amygdala structure and functional connectivity in military Service Members.
amygdala
fMRI
mild traumatic brain injury (mTBI)
post-traumatic stress disorder (PTSD)
resting state functional connectivity
Journal
Frontiers in neuroimaging
ISSN: 2813-1193
Titre abrégé: Front Neuroimaging
Pays: Switzerland
ID NLM: 9918402387106676
Informations de publication
Date de publication:
2023
2023
Historique:
received:
22
12
2022
accepted:
07
02
2023
medline:
9
8
2023
pubmed:
9
8
2023
entrez:
9
8
2023
Statut:
epublish
Résumé
Traumatic brain injury (TBI) is one of the highest public health priorities, especially among military personnel where comorbidity with post-traumatic stress symptoms and resulting consequences is high. Brain injury and post-traumatic stress symptoms are both characterized by dysfunctional brain networks, with the amygdala specifically implicated as a region with both structural and functional abnormalities. This study examined the structural volumetrics and resting state functional connectivity of 68 Active Duty Service Members with or without chronic mild TBI (mTBI) and comorbid symptoms of Post-Traumatic Stress (PTS). Structural analysis of the amygdala revealed no significant differences in volume between mTBI and healthy comparison participants with and without post-traumatic stress symptoms. Resting state functional connectivity with bilateral amygdala revealed decreased anterior network connectivity and increased posterior network connectivity in the mTBI group compared to the healthy comparison group. Within the mTBI group, there were significant regions of correlation with amygdala that were modulated by PTS severity, including networks implicated in emotional processing and executive functioning. An examination of a priori regions of amygdala connectivity in the default mode network, task positive network, and subcortical structures showed interacting influences of TBI and PTS, only between right amygdala and right putamen. These results suggest that mTBI and PTS are associated with hypo-frontal and hyper-posterior amygdala connectivity. Additionally, comorbidity of these conditions appears to compound these neural activity patterns. PTS in mTBI may change neural resource recruitment for information processing between the amygdala and other brain regions and networks, not only during emotional processing, but also at rest.
Identifiants
pubmed: 37554633
doi: 10.3389/fnimg.2023.1129446
pmc: PMC10406312
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1129446Informations de copyright
Copyright At least a portion of this work is authored by Lars Hungerford and Mark L. Ettenhofer on behalf of the U.S. Government and as regards Lars Hungerford and Mark L. Ettenhofer and the U.S. Government, is not subject to copyright protection in the United States. Foreign and other copyrights may apply.
Déclaration de conflit d'intérêts
SG, LH, and ME were employed by General Dynamics Information Technology. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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