Differential projections from the cochlear nucleus to the inferior colliculus in the mouse.
anatomy
auditory
circuits
dextran amine
hearing
projections
tonotopy
Journal
Frontiers in neural circuits
ISSN: 1662-5110
Titre abrégé: Front Neural Circuits
Pays: Switzerland
ID NLM: 101477940
Informations de publication
Date de publication:
2023
2023
Historique:
received:
26
05
2023
accepted:
26
06
2023
medline:
10
8
2023
pubmed:
9
8
2023
entrez:
9
8
2023
Statut:
epublish
Résumé
The cochlear nucleus (CN) is often regarded as the gateway to the central auditory system because it initiates all ascending pathways. The CN consists of dorsal and ventral divisions (DCN and VCN, respectively), and whereas the DCN functions in the analysis of spectral cues, circuitry in VCN is part of the pathway focused on processing binaural information necessary for sound localization in horizontal plane. Both structures project to the inferior colliculus (IC), which serves as a hub for the auditory system because pathways ascending to the forebrain and descending from the cerebral cortex converge there to integrate auditory, motor, and other sensory information. DCN and VCN terminations in the IC are thought to overlap but given the differences in VCN and DCN architecture, neuronal properties, and functions in behavior, we aimed to investigate the pattern of CN connections in the IC in more detail. This study used electrophysiological recordings to establish the frequency sensitivity at the site of the anterograde dye injection for the VCN and DCN of the CBA/CaH mouse. We examined their contralateral projections that terminate in the IC. The VCN projections form a topographic sheet in the central nucleus (CNIC). The DCN projections form a tripartite set of laminar sheets; the lamina in the CNIC extends into the dorsal cortex (DC), whereas the sheets to the lateral cortex (LC) and ventrolateral cortex (VLC) are obliquely angled away. These fields in the IC are topographic with low frequencies situated dorsally and progressively higher frequencies lying more ventrally and/or laterally; the laminae nestle into the underlying higher frequency fields. The DCN projections are complementary to the somatosensory modules of layer II of the LC but both auditory and spinal trigeminal terminations converge in the VLC. While there remains much to be learned about these circuits, these new data on auditory circuits can be considered in the context of multimodal networks that facilitate auditory stream segregation, signal processing, and species survival.
Identifiants
pubmed: 37554670
doi: 10.3389/fncir.2023.1229746
pmc: PMC10405501
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1229746Informations de copyright
Copyright © 2023 Ryugo and Milinkeviciute.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Neurophysiol. 1975 Sep;38(5):1196-1207
pubmed: 1177012
J Neurophysiol. 1963 Mar;26:321-41
pubmed: 13954634
J Assoc Res Otolaryngol. 2022 Jun;23(3):391-412
pubmed: 35381872
J Comp Physiol Psychol. 1948 Feb;41(1):35-9
pubmed: 18904764
J Neurosci. 2001 Oct 1;21(19):7848-58
pubmed: 11567076
J Comp Neurol. 1983 Feb 1;213(4):426-47
pubmed: 6300199
Hear Res. 2010 Feb;260(1-2):96-108
pubmed: 19963054
Neurosci Lett. 1988 Jan 11;84(1):13-7
pubmed: 2831482
Anat Embryol (Berl). 1985;173(2):269-74
pubmed: 3002208
Percept Psychophys. 1993 Sep;54(3):406-16
pubmed: 8414899
Anat Embryol (Berl). 1985;171(1):1-20
pubmed: 3985354
J Comp Neurol. 2012 May 1;520(7):1365-75
pubmed: 22101968
Brain Res. 1973 Aug 30;58(2):331-44
pubmed: 4756133
J Neurosci. 2005 Apr 6;25(14):3680-91
pubmed: 15814799
J Neurocytol. 1980 Aug;9(4):537-70
pubmed: 7441303
J Comp Neurol. 2006 Apr 10;495(5):511-28
pubmed: 16498677
Neuroscience. 2011 Oct 13;193:429-39
pubmed: 21807069
J Comp Neurol. 1972 Mar;144(3):355-72
pubmed: 5027335
J Neurosci. 2016 Oct 26;36(43):11037-11050
pubmed: 27798184
Neuroscience. 1987 Jan;20(1):209-19
pubmed: 3561761
J Neurophysiol. 1994 Jun;71(6):2446-62
pubmed: 7931527
J Vis Exp. 2012 Jun 26;(64):
pubmed: 22781848
J Comp Neurol. 2003 Dec 1;467(1):60-79
pubmed: 14574680
Neurosci Lett. 1982 Oct 23;32(3):241-6
pubmed: 7177487
J Comp Neurol. 1975 Nov 15;164(2):185-207
pubmed: 810498
Psychol Sci. 2011 Jan;22(1):19-25
pubmed: 21123856
Nature. 1976 Dec 23-30;264(5588):746-8
pubmed: 1012311
Handb Clin Neurol. 2015;129:99-116
pubmed: 25726265
J Comp Neurol. 1987 Oct 22;264(4):547-70
pubmed: 2824574
J Comp Neurol. 1997 Aug 25;385(2):245-64
pubmed: 9268126
J Neurosci. 1996 Oct 15;16(20):6554-66
pubmed: 8815932
J Neurophysiol. 2011 Mar;105(3):1063-70
pubmed: 21178001
Acoust Sci Technol. 2020 Jan;41(1):113-120
pubmed: 34305431
Hear Res. 1998 Jun;120(1-2):86-108
pubmed: 9667434
Brain Res. 1987 Jan 1;400(1):145-50
pubmed: 2434184
Brain Res. 1974 Sep 13;77(3):397-415
pubmed: 4854119
Brain Struct Funct. 2019 Dec;224(9):3353-3371
pubmed: 31729553
J Comp Neurol. 1985 Jul 15;237(3):343-59
pubmed: 4044892
Front Neural Circuits. 2022 Oct 20;16:1038500
pubmed: 36338332
Folia Primatol (Basel). 1971;16(1):35-51
pubmed: 4111530
J Comp Neurol. 1973 May 1;149(1):103-15
pubmed: 4700511
Front Neurosci. 2020 Mar 10;14:177
pubmed: 32210751
J Acoust Soc Am. 1989 Feb;85(2):868-78
pubmed: 2926001
Neuroscience. 2014 Jan 31;258:192-203
pubmed: 24252321
J Comp Neurol. 2017 Dec 1;525(17):3742-3756
pubmed: 28786102
Brain Res. 1985 May;352(1):69-82
pubmed: 4005620
J Comp Neurol. 1981 Apr 20;197(4):705-22
pubmed: 7229134
J Comp Neurol. 1984 Nov 1;229(3):432-50
pubmed: 6209306
Sci Rep. 2021 Nov 17;11(1):22442
pubmed: 34789775
J Comp Neurol. 1993 Mar 1;329(1):36-52
pubmed: 8454725
J Comp Neurol. 2013 May 1;521(7):1510-32
pubmed: 23047723
J Comp Neurol. 1987 Aug 8;262(2):215-26
pubmed: 3624552
Anat Rec A Discov Mol Cell Evol Biol. 2006 Apr;288(4):331-44
pubmed: 16550550
J Comp Neurol. 1985 Dec 15;242(3):381-96
pubmed: 2418077
J Comp Neurol. 1975 Jul 15;162(2):247-68
pubmed: 1150921
Percept Mot Skills. 1974 Jun;38(3):1218
pubmed: 4417332
Exp Brain Res. 2003 Dec;153(4):477-85
pubmed: 13680048
Hear Res. 2018 Jul;364:104-117
pubmed: 29598838
J Comp Neurol. 1985 Sep 8;239(2):216-26
pubmed: 4044936
Physiol Behav. 2018 Feb 1;184:205-210
pubmed: 29223710
Exp Brain Res. 2008 Apr;186(4):525-37
pubmed: 18183376
J Comp Neurol. 1980 May 1;191(1):1-51
pubmed: 6772696
Neuroscience. 2008 Jun 12;154(1):196-205
pubmed: 18313229
J Comp Neurol. 1980 Jun 15;191(4):581-606
pubmed: 6158528
J Comp Neurol. 1978 Dec 15;182(4):661-80
pubmed: 721973
Anat Embryol (Berl). 1986;175(2):261-9
pubmed: 2435193
J Comp Neurol. 2005 Apr 4;484(2):191-205
pubmed: 15736230
Exp Brain Res. 1966;1(3):220-35
pubmed: 5920550
J Acoust Soc Am. 2019 Oct;146(4):2709
pubmed: 31671982
J Comp Neurol. 2001 Jul 30;436(3):290-303
pubmed: 11438931
Physiol Behav. 2004 May;81(3):465-73
pubmed: 15135018
J Neurophysiol. 1990 Aug;64(2):465-88
pubmed: 2213127
Anat Embryol (Berl). 1982 Dec;165(3):345-59
pubmed: 7158817
J Comp Neurol. 2014 Mar;522(4):937-49
pubmed: 23982998
J Histochem Cytochem. 1980 Nov;28(11):1255-9
pubmed: 6159394
J Comp Neurol. 1982 Sep 20;210(3):239-57
pubmed: 7142440
Audiology. 1980;19(5):369-83
pubmed: 7436856
Front Neural Circuits. 2013 Jan 03;6:114
pubmed: 23316140
J Comp Neurol. 1979 Apr 1;184(3):547-65
pubmed: 422756
J Neurophysiol. 1988 Dec;60(6):1841-60
pubmed: 2466961
Curr Biol. 1998 Mar 12;8(6):R190
pubmed: 9512426
Physiol Rev. 2010 Jul;90(3):983-1012
pubmed: 20664077
Exp Brain Res. 1973 Jun 29;17(4):402-27
pubmed: 4725899
Brain Res. 1981 Apr 6;210(1-2):342-9
pubmed: 6164444
J Comp Neurol. 2007 Oct 10;504(5):583-98
pubmed: 17701985
Brain Behav Evol. 1989;34(4):193-200
pubmed: 2590835
Cells Tissues Organs. 2002;170(1):61-8
pubmed: 11602803
J Neurosci. 2013 Aug 21;33(34):13686-94
pubmed: 23966690
Brain Res. 1978 Apr 28;145(2):209-23
pubmed: 638786
Brain Res. 1985 Apr 29;333(1):123-30
pubmed: 3995280
J Assoc Res Otolaryngol. 2003 Jun;4(2):148-63
pubmed: 12943370
Hear Res. 1992 Mar;58(2):132-52
pubmed: 1568936
Neuroscience. 2008 Jun 12;154(1):99-113
pubmed: 18222048
Neuroreport. 2000 Jun 26;11(9):2057-61
pubmed: 10884070
Front Neural Circuits. 2022 Apr 07;16:882485
pubmed: 35463204
J Basic Clin Physiol Pharmacol. 1996;7(3):199-220
pubmed: 8910137
Behav Brain Res. 1998 Dec;97(1-2):1-12
pubmed: 9867226
J Comp Neurol. 1984 Jan 10;222(2):209-36
pubmed: 6699208
J Comp Neurol. 2006 Mar 1;495(1):100-12
pubmed: 16432905
Brain Res. 1984 Aug 20;309(1):159-62
pubmed: 6488006
Anat Embryol (Berl). 1984;170(1):29-43
pubmed: 6089608
J Comp Neurol. 1996 Jan 29;365(1):159-72
pubmed: 8821448
Brain Res Bull. 2003 Jun 15;60(5-6):475-95
pubmed: 12787868
Trends Neurosci. 2005 May;28(5):255-63
pubmed: 15866200
Hear Res. 2006 Jun-Jul;216-217:90-9
pubmed: 16513306
Acta Biol Hung. 2002;53(1-2):7-21
pubmed: 12064781
J Comp Neurol. 1976 Nov 1;170(1):107-21
pubmed: 61976
J Comp Neurol. 1962 Oct;119:211-27
pubmed: 13990676
Hear Res. 2006 Jun-Jul;216-217:64-72
pubmed: 16497454
J Comp Neurol. 1985 Aug 1;238(1):65-76
pubmed: 4044904
J Comp Neurol. 1999 Jun 14;408(4):515-31
pubmed: 10340502
Comp Biochem Physiol A Mol Integr Physiol. 2000 Aug;126(4):459-69
pubmed: 10989338
Hear Res. 2017 Jan;343:34-49
pubmed: 27421755
Front Neurosci. 2019 Aug 27;13:897
pubmed: 31507369
Prog Neurobiol. 2000 Aug;61(6):581-610
pubmed: 10775798
J Comp Neurol. 1984 Apr 1;224(2):155-72
pubmed: 19180810
Behav Brain Res. 2013 Mar 1;240:160-70
pubmed: 23195112
J Comp Neurol. 1967 May;130(1):77-86
pubmed: 4962091
Hear Res. 1998 Feb;116(1-2):33-42
pubmed: 9508026
J Neurophysiol. 1989 Jan;61(1):149-61
pubmed: 2918341
J Comp Neurol. 2003 Jul 7;461(4):452-65
pubmed: 12746862
J Comp Neurol. 1979 Feb 1;183(3):519-38
pubmed: 759446
Hear Res. 1998 Jan;115(1-2):61-81
pubmed: 9472736
Neuroscience. 1984 Nov;13(3):827-54
pubmed: 6527780
J Comp Neurol. 2016 Aug 1;524(11):2230-50
pubmed: 26659473
Hear Res. 2006 Nov;221(1-2):104-18
pubmed: 17005343
J Neurophysiol. 1986 Aug;56(2):287-307
pubmed: 3760922
J Acoust Soc Am. 1989 Feb;85(2):858-67
pubmed: 2926000
J Physiol. 2018 Sep;596(18):4537-4548
pubmed: 30074618
J Assoc Res Otolaryngol. 2016 Dec;17(6):493-523
pubmed: 27752925
Exp Neurol. 1975 Oct;49(1 Pt 1):281-90
pubmed: 1183527
J Neurophysiol. 1969 Jul;32(4):613-36
pubmed: 5810617
Brain Res Bull. 2003 Jun 15;60(5-6):457-74
pubmed: 12787867
Neurosci Lett. 2023 Jan 10;793:136976
pubmed: 36427816
J Comp Neurol. 1981 Feb 10;196(1):25-40
pubmed: 7204665
Brain Res. 1973 Jan 30;49(2):229-44
pubmed: 4720788
Philos Trans R Soc Lond B Biol Sci. 1992 Jun 29;336(1278):407-13
pubmed: 1354382
Hear Res. 2014 Aug;314:51-9
pubmed: 24911237
J Comp Neurol. 2017 Mar 1;525(4):773-793
pubmed: 27513294
Ann Otol Rhinol Laryngol Suppl. 1997 May;168:31-4
pubmed: 9153114
Brain Res Brain Res Rev. 1990 Sep-Dec;15(3):295-323
pubmed: 2289088
J Neurophysiol. 1978 Jul;41(4):837-47
pubmed: 681989
J Comp Physiol Psychol. 1975 Jul;89(5):379-86
pubmed: 1194445
Contrib Sens Physiol. 1970;4:143-213
pubmed: 4914058
Hear Res. 2017 Jan;343:14-33
pubmed: 27473502
J Assoc Res Otolaryngol. 2023 Jun;24(3):365-384
pubmed: 37156973
J Comp Neurol. 1973 Jan 1;147(1):11-60
pubmed: 4682181
Hear Res. 2005 Apr;202(1-2):63-73
pubmed: 15811700
Rev Oculomot Res. 1989;3:213-55
pubmed: 2486324
J Comp Neurol. 1974 Jun 1;155(3):251-300
pubmed: 4134212
Neuroscience. 2005;136(3):883-94
pubmed: 16344158