Comparison of two frailty definitions in women with systemic lupus erythematosus.

Frailty disability patient-reported outcome measures systemic lupus erythematosus

Journal

Rheumatology (Oxford, England)
ISSN: 1462-0332
Titre abrégé: Rheumatology (Oxford)
Pays: England
ID NLM: 100883501

Informations de publication

Date de publication:
09 Aug 2023
Historique:
received: 17 01 2023
revised: 21 06 2023
accepted: 11 07 2023
medline: 9 8 2023
pubmed: 9 8 2023
entrez: 9 8 2023
Statut: aheadofprint

Résumé

Frailty is a risk factor for adverse health in systemic lupus erythematosus (SLE). The Fried phenotype (FP) and the Systemic Lupus International Collaborating Clinics Frailty Index (SLICC-FI) are common frailty metrics reflecting distinct approaches to frailty assessment. We aimed to 1) compare frailty prevalence according to both metrics in women with SLE and describe differences between frail and non-frail participants using each method and 2) evaluate for cross-sectional associations between each metric and self-report disability. Women aged 18-70 years with SLE were enrolled. FP and SLICC-FI were measured, and agreement calculated using a kappa statistic. Physician-reported disease activity and damage, Patient Reported Outcome Measurement Information System (PROMIS) computerized adaptive tests, and Valued Life Activities (VLA) self-report disability were assessed. Differences between frail and non-frail participants were evaluated cross-sectionally, and the association of frailty with disability was determined for both metrics. Of 67 participants, 17.9% (FP) and 26.9% (SLICC-FI) were frail according to each metric (kappa = 0.41, p< 0.01). Compared with non-frail women, frail women had greater disease damage, worse PROMIS scores, and greater disability (all p< 0.01 for FP and SLICC-FI). After age adjustment, frailty remained associated with a greater odds of disability (FP: odds ratio [OR] 4.7, 95% confidence interval [CI] 1.2-18.8; SLICC-FI: OR 4.6, 95% CI 1.3-15.8). Frailty is present in 17.9-26.9% of women with SLE. These metrics identified a similar, but non-identical group of women as frail. Further studies are needed to explore which metric is most informative in this population.

Identifiants

pubmed: 37555816
pii: 7239859
doi: 10.1093/rheumatology/kead393
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© The Author(s) 2023. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Auteurs

Sarah B Lieber (SB)

Division of Rheumatology, Hospital for Special Surgery, New York, NY, USA.
Department of Medicine, Weill Cornell Medicine, New York, NY, USA.

Musarrat Nahid (M)

Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Division of General Internal Medicine, Weill Cornell Medicine, New York, NY, USA.

Alexandra Legge (A)

Division of Rheumatology, Dalhousie University, Halifax, NS, Canada.

Mangala Rajan (M)

Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Division of General Internal Medicine, Weill Cornell Medicine, New York, NY, USA.

Robyn A Lipschultz (RA)

New York University Grossman School of Medicine, New York, NY, USA.

Myriam Lin (M)

Rutgers New Jersey Medical School, Newark, NJ, USA.

M Carrington Reid (MC)

Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Division of Geriatrics and Palliative Medicine, Weill Cornell Medicine, New York, NY, USA.

Lisa A Mandl (LA)

Division of Rheumatology, Hospital for Special Surgery, New York, NY, USA.
Department of Medicine, Weill Cornell Medicine, New York, NY, USA.

Classifications MeSH